The identification of lesion within medical image data is necessary for diagnosis, treatment and prognosis. Segmentation and classification approaches are mainly based on supervised learning with well-paired image-level or voxel-level labels. However, labeling the lesion in medical images is laborious requiring highly specialized knowledge. We propose a medical image synthesis model named abnormal-to-normal translation generative adversarial network (ANT-GAN) to generate a normal-looking medical image based on its abnormal-looking counterpart without the need for paired training data. Unlike typical GANs, whose aim is to generate realistic samples with variations, our more restrictive model aims at producing a normal-looking image corresponding to one containing lesions, and thus requires a special design. Being able to provide a “normal” counterpart to a medical image can provide useful side information for medical imaging tasks like lesion segmentation or classification validated by our experiments. In the other aspect, the ANT-GAN model is also capable of producing highly realistic lesion-containing image corresponding to the healthy one, which shows the potential in data augmentation verified in our experiments.

In this paper, we propose TopicRNN, a recurrent neural network (RNN)-based language model designed to directly capture the global semantic meaning relating words in a document via latent topics. Because of their sequential nature, RNNs are good at capturing the local structure of a word sequence - both semantic and syntactic - but might face difficulty remembering long-range dependencies. Intuitively, these long-range dependencies are of semantic nature. In contrast, latent topic models are able to capture the global underlying semantic structure of a document but do not account for word ordering. The proposed TopicRNN model integrates the merits of RNNs and latent topic models: it captures local (syntactic) dependencies using an RNN and global (semantic) dependencies using latent topics. Unlike previous work on contextual RNN language modeling, our model is learned end-to-end. Empirical results on word prediction show that TopicRNN outperforms existing contextual RNN baselines. In addition, TopicRNN can be used as an unsupervised feature extractor for documents. We do this for sentiment analysis on the IMDB movie review dataset and report an error rate of $6.28\%$. This is comparable to the state-of-the-art $5.91\%$ resulting from a semi-supervised approach. Finally, TopicRNN also yields sensible topics, making it a useful alternative to document models such as latent Dirichlet allocation.

We present the collaborative Kalman filter (CKF), a dynamic model for collaborative filtering and related factorization models. Using the matrix factorization approach to collaborative filtering, the CKF accounts for time evolution by modeling each low-dimensional latent embedding as a multidimensional Brownian motion. Each observation is a random variable whose distribution is parameterized by the dot product of the relevant Brownian motions at that moment in time. This is naturally interpreted as a Kalman filter with multiple interacting state space vectors. We also present a method for learning a dynamically evolving drift parameter for each location by modeling it as a geometric Brownian motion. We handle posterior intractability via a mean-field variational approximation, which also preserves tractability for downstream calculations in a manner similar to the Kalman filter. We evaluate the model on several large datasets, providing quantitative evaluation on the 10 million Movielens and 100 million Netflix datasets and qualitative evaluation on a set of 39 million stock returns divided across roughly 6,500 companies from the years 1962-2014.

We present a Bayesian tensor factorization model for inferring latent group structures from dynamic pairwise interaction patterns. For decades, political scientists have collected and analyzed records of the form "country $i$ took action $a$ toward country $j$ at time $t$"---known as dyadic events---in order to form and test theories of international relations. We represent these event data as a tensor of counts and develop Bayesian Poisson tensor factorization to infer a low-dimensional, interpretable representation of their salient patterns. We demonstrate that our model's predictive performance is better than that of standard non-negative tensor factorization methods. We also provide a comparison of our variational updates to their maximum likelihood counterparts. In doing so, we identify a better way to form point estimates of the latent factors than that typically used in Bayesian Poisson matrix factorization. Finally, we showcase our model as an exploratory analysis tool for political scientists. We show that the inferred latent factor matrices capture interpretable multilateral relations that both conform to and inform our knowledge of international affairs.

We propose a deep generative factor analysis model with beta process prior that can approximate complex non-factorial distributions over the latent codes. We outline a stochastic EM algorithm for scalable inference in a specific instantiation of this model and present some preliminary results.

In this paper, we propose a fully supervised speaker diarization approach, named unbounded interleaved-state recurrent neural networks (UIS-RNN). Given extracted speaker-discriminative embeddings (a.k.a. d-vectors) from input utterances, each individual speaker is modeled by a parameter-sharing RNN, while the RNN states for different speakers interleave in the time domain. This RNN is naturally integrated with a distance-dependent Chinese restaurant process (ddCRP) to accommodate an unknown number of speakers. Our system is fully supervised and is able to learn from examples where time-stamped speaker labels are annotated. We achieved a 7.6% diarization error rate on NIST SRE 2000 CALLHOME, which is better than the state-of-the-art method using spectral clustering. Moreover, our method decodes in an online fashion while most state-of-the-art systems rely on offline clustering.