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A growing body of evidence indicates that early-term births (37–38 weeks of gestational age) have an increased risk of short-term and long-term complications. Here, we sought to explore the association between early-term births and the risk of delayed neurodevelopment at age 2 years. Pregnant women and their live singleton birth were recruited from a single tertiary hospital between October 2013 and February 2017. Mental and Psychomotor Development Indexes (MDI and PDI) were assessed using the Bayley Scales of Infant Development (BSID). Delayed neurodevelopment was defined as scores of PDI or MDI less than −1SD relative to the mean score of the study population. In total, 1678 full-term infants and 727 early-term infants were assessed when they were 2 years old. After adjustment for potential confounders, early-term birth was related to 43% increased odds of neurodevelopmental delay in the PDI domain as compared with full-term birth (OR: 1.43; 95% CI: 1.12, 1.82). The observed associations were more prominent among those infants born by cesarean (OR: 1.44; 95% CI: 1.03, 2.00) and among males (OR: 1.66; 95% CI: 1.20, 2.28). No statistical difference in the MDI domain was found between early-term and full-term births. Conclusions: Our findings suggest that early-term birth was associated with increased odds of delayed neurodevelopment in the PDI domain as measured by BSID assessments at age 2 years. Health professionals should be aware of the influence of early-term birth on the risk of delayed neurodevelopment.
Mingyang Wu; Lulin Wang; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Aifen Zhou; Zhongqiang Cao; Youjie Wang; Rong Yang. Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China. European Journal of Pediatrics 2021, 1 -9.
AMA StyleMingyang Wu, Lulin Wang, Yunyun Liu, Jianing Bi, Qing Liu, Kai Chen, Yuanyuan Li, Wei Xia, Shunqing Xu, Aifen Zhou, Zhongqiang Cao, Youjie Wang, Rong Yang. Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China. European Journal of Pediatrics. 2021; ():1-9.
Chicago/Turabian StyleMingyang Wu; Lulin Wang; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Aifen Zhou; Zhongqiang Cao; Youjie Wang; Rong Yang. 2021. "Association between early-term birth and delayed neurodevelopment at the age of 2 years: results from a cohort study in China." European Journal of Pediatrics , no. : 1-9.
In the context of global climate change, research efforts were focused on the association of ambient temperatures on maternal and neonatal health condition, but few have examined associations with low Apgar scores. From January 1, 2017, to December 31, 2018, all singleton deliveries of Ningxia Hui Autonomous Region were extracted from the Hospital Information System (N = 182,322). Daily temperature data were obtained from the official website of China Meteorological Administration. Low Apgar scores were defined as Apgar score ≤ 3 at 5 min in the present study. Logistic regression models were used to estimate the adjusted association between prenatal temperature exposure and low Apgar scores. Restricted cubic spline models were used to explore the dose-response relationship between temperature and low Apgar scores. The study population included 182,322 live singleton births, with 1575 (0.86%) cases of low Apgar scores. The elevated ambient temperature in different exposure timing windows in late pregnancy was associated with increased risk of low Apgar scores. As compared to moderate (10th–90th) temperature exposure, prenatal exposure to extreme hot (>90th) was associated with 13.9–47.0% increased risk of low Apgar scores, while non-significant relationship was found between extreme cold (<10th) exposure and low Apgar scores. The restricted cubic spline models showed a U-shaped relationship between prenatal temperature exposure and low Apgar scores (P for non-linearity < 0.05). Exposure to high ambient temperature during late pregnancy is associated with an increased risk of low Apgar scores in northwest China.
Zezhong Tang; Mingyang Wu; Guangrong Song; Rong Yang; Youjie Wang. Impact of ambient temperature exposure on newborns with low Apgar scores in northwest China. Environmental Science and Pollution Research 2021, 1 -8.
AMA StyleZezhong Tang, Mingyang Wu, Guangrong Song, Rong Yang, Youjie Wang. Impact of ambient temperature exposure on newborns with low Apgar scores in northwest China. Environmental Science and Pollution Research. 2021; ():1-8.
Chicago/Turabian StyleZezhong Tang; Mingyang Wu; Guangrong Song; Rong Yang; Youjie Wang. 2021. "Impact of ambient temperature exposure on newborns with low Apgar scores in northwest China." Environmental Science and Pollution Research , no. : 1-8.
Telomere length (TL) is a biomarker for biological aging, and the initial setting of TL at birth is a determinant factor of TL in later life. Newborn TL is sensitive to maternal metals concentrations, while study about the association between maternal manganese (Mn) concentrations and newborn TL was not found. Our study aimed to investigate whether newborn TL is related to maternal Mn concentrations. Data were collected from a birth cohort study of 762 mother-newborn pairs conducted from November 2013 to March 2015 in Wuhan, China. We measured the Mn concentrations in spot urine samples collected during three trimesters by inductively coupled plasma mass spectrometry (ICP-MS) and relative cord blood TL by quantitative real-time polymerase chain reaction (qPCR). We applied multiple informant models to investigate the associations between maternal Mn concentrations and cord blood TL. The geometric mean of creatinine-corrected urinary Mn concentrations were 1.58 μg/g creatinine, 2.53 μg/g creatinine, and 2.62 μg/g creatinine in the first, second, and third trimester, respectively. After adjusting for potential confounders, a doubling of maternal urinary Mn concentration during the second trimester was related to a 2.10% (95% CI: 0.25%, 3.99%) increase in cord blood TL. Mothers with the highest tertile of urinary Mn concentrations during the second trimester had a 9.67% (95% CI: 2.13%, 17.78%) longer cord blood TL than those with the lowest tertile. This association was more evident in male infants. No relationship was found between maternal urinary Mn concentrations and cord blood TL during the first and third trimesters in our study. Our findings suggested that maternal Mn concentration during the second trimester was positively associated with newborn TL. These results might provide an epidemiology evidence on the protective role of maternal Mn for newborn TL and offer clues for the early prevention of telomere shortening related diseases.
Jianing Bi; Mingyang Wu; Yunyun Liu; Lulu Song; Lulin Wang; Qing Liu; Kai Chen; Chao Xiong; Yuanyuan Li; Wei Xia; Shunqing Xu; Aifen Zhou; Youjie Wang. Association between maternal urinary manganese concentrations and newborn telomere length: Results from a birth cohort study. Ecotoxicology and Environmental Safety 2021, 213, 112037 .
AMA StyleJianing Bi, Mingyang Wu, Yunyun Liu, Lulu Song, Lulin Wang, Qing Liu, Kai Chen, Chao Xiong, Yuanyuan Li, Wei Xia, Shunqing Xu, Aifen Zhou, Youjie Wang. Association between maternal urinary manganese concentrations and newborn telomere length: Results from a birth cohort study. Ecotoxicology and Environmental Safety. 2021; 213 ():112037.
Chicago/Turabian StyleJianing Bi; Mingyang Wu; Yunyun Liu; Lulu Song; Lulin Wang; Qing Liu; Kai Chen; Chao Xiong; Yuanyuan Li; Wei Xia; Shunqing Xu; Aifen Zhou; Youjie Wang. 2021. "Association between maternal urinary manganese concentrations and newborn telomere length: Results from a birth cohort study." Ecotoxicology and Environmental Safety 213, no. : 112037.
The widespread exploitation and application of rare earth elements (REE) have led to the risk of human exposure and might result in the adverse health effect on pregnant women. However, no epidemiological studies have explored the associations between prenatal REE exposure and premature rupture of membranes (PROM). We aimed to investigate the associations of maternal urinary REE levels with the risk of PROM. A total of 4897 mother-newborn pairs were recruited from a birth cohort study in Wuhan, China. Urinary concentrations of REE were measured by inductively coupled plasma mass spectrometry (ICP-MS). The associations of prenatal REE exposure with PROM were evaluated using logistic regression models. False discovery rate (FDR) was applied to adjust for multiple testing. Weighted quantile sum (WQS) regression was used to estimate the association of urinary REE mixture with PROM. With one unit increase (μg/g creatinine) in natural log-transformed urinary REE levels (Ce, Yb, La, Pr, Nd, Eu, Gd, Dy, Ho, Er, Tm), the adjusted ORs (95% CIs) for the PROM were from 1.143 (1.078, 1.211) to 1.317 (1.223, 1.419), and the associations were still observed after FDR adjustment (all PFDRs < 0.05). The associations were stronger among male infants than female infants. Furthermore, the urinary REE mixture was also associated with the risk of PROM, a quartile increase in the WQS index of REE resulted in ORs (95% CI) for the PROM of 1.494 (1.356, 1.645) in the adjusted model. Our findings suggested that prenatal exposure to REE (Ce, Yb, La, Pr, Nd, Eu, Gd, Dy, Ho, Er, and Tm) and REE mixture were associated with the increased risk of PROM. Further studies from different populations are needed to confirm the associations and to explore the mechanisms.
Yunyun Liu; Mingyang Wu; Lulu Song; Jianing Bi; Lulin Wang; Kai Chen; Qing Liu; Chao Xiong; Zhongqiang Cao; Yuanyuan Li; Wei Xia; Shunqing Xu; Youjie Wang. Association between prenatal rare earth elements exposure and premature rupture of membranes: Results from a birth cohort study. Environmental Research 2020, 193, 110534 .
AMA StyleYunyun Liu, Mingyang Wu, Lulu Song, Jianing Bi, Lulin Wang, Kai Chen, Qing Liu, Chao Xiong, Zhongqiang Cao, Yuanyuan Li, Wei Xia, Shunqing Xu, Youjie Wang. Association between prenatal rare earth elements exposure and premature rupture of membranes: Results from a birth cohort study. Environmental Research. 2020; 193 ():110534.
Chicago/Turabian StyleYunyun Liu; Mingyang Wu; Lulu Song; Jianing Bi; Lulin Wang; Kai Chen; Qing Liu; Chao Xiong; Zhongqiang Cao; Yuanyuan Li; Wei Xia; Shunqing Xu; Youjie Wang. 2020. "Association between prenatal rare earth elements exposure and premature rupture of membranes: Results from a birth cohort study." Environmental Research 193, no. : 110534.
Background: Thallium is a widely known toxic heavy metal that has been reported have embryo toxicity.Objective: We aimed to investigate the relationship of prenatal thallium exposure with neonatal telomere length.Methods: A total of 746 mother-newborn pairs were recruited from Wuhan Children Hospital between November 2013 and March 2015 in Wuhan City, China. Maternal thallium exposure levels were measured in spot urine samples collected during the three trimesters and during hospital delivery using inductively coupled plasma mass spectrometry. Neonatal relative telomere length (rTL) was measured by a real-time quantitative polymerase chain reaction assay in cord blood. Multiple informant models were used to evaluate the association of maternal thallium exposure with neonatal rTL.Results: After adjustment for multiple potential confounders, each 25% incremental increase of maternal thallium exposure, measured in urine samples collected during hospital delivery, was associated with a 1.85% shortened neonatal rTL (95% CI: -3.62%, -0.05%; P = 0.044). Similarly, mothers in the highest quartile of urinary thallium exposure had a 11.74% (95% CI: -21.57%, -0.68%; P = 0.038) shorter cord blood leukocyte rTL than those in the lowest quartile. However, no significant association was found between neonatal rTL and maternal thallium exposure measured in urine samples collected during the three trimesters of pregnancy.Conclusions: This study reveals that prenatal thallium exposure was related to shortened neonatal telomere length in Chinese population, pointing to the important role of thallium exposure in accelerating biological aging.
Mingyang Wu; Lulin Wang; Lulu Song; Bingqing Liu; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Zhongqiang Cao; Aifen Zhou; Yaohua Tian; Youjie Wang. The association between prenatal exposure to thallium and shortened telomere length of newborns. Chemosphere 2020, 265, 129025 .
AMA StyleMingyang Wu, Lulin Wang, Lulu Song, Bingqing Liu, Yunyun Liu, Jianing Bi, Qing Liu, Kai Chen, Yuanyuan Li, Wei Xia, Shunqing Xu, Zhongqiang Cao, Aifen Zhou, Yaohua Tian, Youjie Wang. The association between prenatal exposure to thallium and shortened telomere length of newborns. Chemosphere. 2020; 265 ():129025.
Chicago/Turabian StyleMingyang Wu; Lulin Wang; Lulu Song; Bingqing Liu; Yunyun Liu; Jianing Bi; Qing Liu; Kai Chen; Yuanyuan Li; Wei Xia; Shunqing Xu; Zhongqiang Cao; Aifen Zhou; Yaohua Tian; Youjie Wang. 2020. "The association between prenatal exposure to thallium and shortened telomere length of newborns." Chemosphere 265, no. : 129025.
Objective: To evaluate the epidemiological and clinical characteristics of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers (HCWs) in Hubei Province, China. Design: Retrospective cohort study. Setting: Hubei Provincial Center for Disease Control and Prevention. Participants: The participants in this study are cases identified by epidemiological investigation in Hubei Province, as of February 27, 2020, and were followed until March 7, 2020. In total, 1,989 HCWs and 41,137 other occupational cases were included for analysis. Methods: We used descriptive statistics to summarize patient characteristics. Results: Of 1,989 laboratory-confirmed HCWs, 297 (14.93%) had severe or critical cases, 73 (3.67%) had asymptomatic infections, and 18 died of coronavirus disease 2019 (COVID-19). The case fatality rate was 0.9%. The proportion of severe or critical cases decreased from the beginning to the end of the outbreak (from 21.29% to 3.52%), and the proportion of asymptomatic cases increased from 0.0% to 47.18%. Nearly half of HCWs with confirmed COVID-19 reported no known contact with COVID-19 patients (969, 48.72%). Fever and cough were the most common symptoms at disease onset in both HCWs and other occupational cases; however, HCWs had higher rates of fatigue (30.90% vs 25.02%; P < .001) and myalgia (19.15% vs 13.43%; P < .001). Additionally, compared with other occupational groups, HCWs were associated with a lower risk of death after adjustment for potential confounders (odd ratio [OR], 0.50; 95% confidence interval [CI], 0.30–0.79). Conclusions: Compared with COVID-19 cases in other occupational groups, HCWs with COVID-19 have half the risk of death, although they have been shown to have higher rates of fatigue and myalgia.
Mingyang Wu; Cong Xie; Ran Wu; Yanling Shu; Lulin Wang; Mingyan Li; Youjie Wang. Epidemiological and clinical characteristics of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers in Hubei Province, China. Infection Control & Hospital Epidemiology 2020, 1 -7.
AMA StyleMingyang Wu, Cong Xie, Ran Wu, Yanling Shu, Lulin Wang, Mingyan Li, Youjie Wang. Epidemiological and clinical characteristics of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers in Hubei Province, China. Infection Control & Hospital Epidemiology. 2020; ():1-7.
Chicago/Turabian StyleMingyang Wu; Cong Xie; Ran Wu; Yanling Shu; Lulin Wang; Mingyan Li; Youjie Wang. 2020. "Epidemiological and clinical characteristics of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection among healthcare workers in Hubei Province, China." Infection Control & Hospital Epidemiology , no. : 1-7.
Lulu Song; Bingqing Liu; Lulin Wang; Mingyang Wu; Lina Zhang; Yunyun Liu; Jianing Bi; Senbei Yang; Bin Zhang; Wei Xia; Shunqing Xu; Ruoling Chen; Zhongqiang Cao; Youjie Wang. Corrigendum to “Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China” [Chemosphere 243 (2020) 125335]. Chemosphere 2020, 268, 128828 .
AMA StyleLulu Song, Bingqing Liu, Lulin Wang, Mingyang Wu, Lina Zhang, Yunyun Liu, Jianing Bi, Senbei Yang, Bin Zhang, Wei Xia, Shunqing Xu, Ruoling Chen, Zhongqiang Cao, Youjie Wang. Corrigendum to “Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China” [Chemosphere 243 (2020) 125335]. Chemosphere. 2020; 268 ():128828.
Chicago/Turabian StyleLulu Song; Bingqing Liu; Lulin Wang; Mingyang Wu; Lina Zhang; Yunyun Liu; Jianing Bi; Senbei Yang; Bin Zhang; Wei Xia; Shunqing Xu; Ruoling Chen; Zhongqiang Cao; Youjie Wang. 2020. "Corrigendum to “Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China” [Chemosphere 243 (2020) 125335]." Chemosphere 268, no. : 128828.
Background The coronavirus disease 2019 (COVID-19) outbreak is evolving rapidly worldwide. However, little is known about the association between pregnant women with COVID-19 and the risk of adverse birth outcomes. Method We conducted a retrospective cohort study based on the Maternal and Child Health Information System (MCHIMS) of Wuhan, China. All pregnant women with singleton live birth recorded by the system between January 13 and March 18, 2020, were included. The adverse birth outcomes were preterm birth, low birth weight, neonatal asphyxia, premature rupture of membrane (PROM), and cesarean section delivery. Multivariate logistic regression was used to evaluate the associations between maternal COVID-19 diagnosis and adverse birth outcomes. Results Out of 11,078 pregnant women, 65 were confirmed with coronavirus disease 2019 (COVID-19). No deaths occurred from these confirmed cases or their newborns. Compared to pregnant women without COVID-19, pregnant women with a confirmed COVID-19 diagnosis had an increased risk of preterm birth (OR 3.34, 95% CI 1.60–7.00) and cesarean section (OR 3.63, 95% CI 1.95–6.76). There was no statistical difference in low birth weight, neonatal asphyxia, and PROM between the mothers with and without COVID-19. Among these newborns that were born to mothers with confirmed COVID-19, none was tested severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive or had abnormal CT results. Only one had diarrhea and three had a fever. Conclusions This population-based cohort study suggests that COVID-19 during the later pregnancy is associated with an increased risk of adverse birth outcomes, including iatrogenic preterm birth and cesarean section delivery. Our data provide little evidence for maternal-fetal vertical transmission of SARS-CoV-2. It is important to monitor the long-term health effects of SARS-CoV-2 infection on pregnant women and their children.
Rong Yang; Hui Mei; Tongzhang Zheng; Qiang Fu; Yiming Zhang; Stephen Buka; Xinan Yao; Zezhong Tang; Xichi Zhang; Lin Qiu; Yaqi Zhang; Jieqiong Zhou; Jiangxia Cao; Youjie Wang; Aifen Zhou. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Medicine 2020, 18, 1 -7.
AMA StyleRong Yang, Hui Mei, Tongzhang Zheng, Qiang Fu, Yiming Zhang, Stephen Buka, Xinan Yao, Zezhong Tang, Xichi Zhang, Lin Qiu, Yaqi Zhang, Jieqiong Zhou, Jiangxia Cao, Youjie Wang, Aifen Zhou. Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China. BMC Medicine. 2020; 18 (1):1-7.
Chicago/Turabian StyleRong Yang; Hui Mei; Tongzhang Zheng; Qiang Fu; Yiming Zhang; Stephen Buka; Xinan Yao; Zezhong Tang; Xichi Zhang; Lin Qiu; Yaqi Zhang; Jieqiong Zhou; Jiangxia Cao; Youjie Wang; Aifen Zhou. 2020. "Pregnant women with COVID-19 and risk of adverse birth outcomes and maternal-fetal vertical transmission: a population-based cohort study in Wuhan, China." BMC Medicine 18, no. 1: 1-7.
Although some persistent organic pollutants (POPs) were prohibited or limited in use several decades ago, they are still frequently detected in the human body. The purpose of this study was to understand the levels and profiles of POPs in breast milk in China and assess their potential health risks among breastfed infants under six months of age. A literature review focused on China was performed for studies published from 2001 to 2020. The POP levels in breast milk along with other important variables were extracted, and then the average individual POP levels in breast milk were estimated. This review summarises the distribution of traditional and new POPs, including polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), legacy brominated flame retardants (BFRs), perfluorinated compounds (PFCs), and chlorinated paraffins (CPs) and reported notably high levels of short-chain chlorinated paraffins and 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p’-DDE) in breast milk. Although the levels of traditional POPs generally declined over time, especially p,p’-DDE and beta-hexachlorocyclohexane (β-HCH), women living in coastal areas, urban areas, and southern China still have a high body burden of certain POPs. In the present study, the estimated daily intake (EDI) of POPs through breastfeeding was used to evaluate the health risk for infants by comparing with acceptable levels. The findings suggested that infants born in coastal areas most likely suffered potential health risk from exposure to DDT, and the health risk of hexachlorobenzene (HCB) in infants in most nationwide regions remains a concern. More importantly, the EDI of PCBs for infants exceeds the safe limit on a national scale. Continuous surveillance of PCBs in breast milk is critical to evaluate the potential health effects on humans.
Liqin Hu; Dan Luo; Limei Wang; Meng Yu; Shizhen Zhao; Youjie Wang; Surong Mei; Gan Zhang. Levels and profiles of persistent organic pollutants in breast milk in China and their potential health risks to breastfed infants: A review. Science of The Total Environment 2020, 753, 142028 .
AMA StyleLiqin Hu, Dan Luo, Limei Wang, Meng Yu, Shizhen Zhao, Youjie Wang, Surong Mei, Gan Zhang. Levels and profiles of persistent organic pollutants in breast milk in China and their potential health risks to breastfed infants: A review. Science of The Total Environment. 2020; 753 ():142028.
Chicago/Turabian StyleLiqin Hu; Dan Luo; Limei Wang; Meng Yu; Shizhen Zhao; Youjie Wang; Surong Mei; Gan Zhang. 2020. "Levels and profiles of persistent organic pollutants in breast milk in China and their potential health risks to breastfed infants: A review." Science of The Total Environment 753, no. : 142028.
Rare earth elements (REE) have been widely used in industry and agriculture. Mitochondria are susceptible to environmental exposure and the change of mitochondrial DNA (mtDNA) content is a proxy indicator of mitochondrial response to damage. However, no study has explored the associations between prenatal repeated REE exposure and newborn mtDNA content. We aimed to investigate the trimester-specific associations between prenatal REE exposure and newborn mtDNA content. A total of 587 mother-newborn pairs were recruited from Wuhan Children’s Hospital between November 2013 and March 2015 in Wuhan, China. Urinary concentrations of REE collected during 3 trimesters were measured by inductively coupled plasma mass spectrometry (ICP-MS). Quantitative real-time polymerase chain reaction (qPCR) was used to measure relative cord blood mtDNA content. We evaluated the trimester-specific associations between prenatal REE exposure and relative cord blood mtDNA content with multiple informant models. False discovery rate (FDR) was used to correct for multiple testing. After adjustment for potential confounders, prenatal exposure to REE [gadolinium (Gd), dysprosium (Dy), erbium (Er), praseodymium (Pr)] during the third trimester were positively related to cord blood mtDNA content, and the positive associations with cord blood mtDNA content were still observed in Dy, Er, and Pr after FDR correction. This prospective study demonstrated that maternal REE exposure during the third trimester was associated with the increased newborn mtDNA content, and the third trimester might be a potential window for sensitivity of newborn mtDNA content to REE exposure. The results might provide evidence of the potential health effects of environmental REE exposure.
Yunyun Liu; Mingyang Wu; Bingqing Liu; Lulu Song; Jianing Bi; Lulin Wang; Shikha Upadhyaya Khatiwada; Kai Chen; Qing Liu; Chao Xiong; Yuanyuan Li; Wei Xia; Shunqing Xu; Youjie Wang; Aifen Zhou. Association of prenatal exposure to rare earth elements with newborn mitochondrial DNA content: Results from a birth cohort study. Environment International 2020, 143, 105863 .
AMA StyleYunyun Liu, Mingyang Wu, Bingqing Liu, Lulu Song, Jianing Bi, Lulin Wang, Shikha Upadhyaya Khatiwada, Kai Chen, Qing Liu, Chao Xiong, Yuanyuan Li, Wei Xia, Shunqing Xu, Youjie Wang, Aifen Zhou. Association of prenatal exposure to rare earth elements with newborn mitochondrial DNA content: Results from a birth cohort study. Environment International. 2020; 143 ():105863.
Chicago/Turabian StyleYunyun Liu; Mingyang Wu; Bingqing Liu; Lulu Song; Jianing Bi; Lulin Wang; Shikha Upadhyaya Khatiwada; Kai Chen; Qing Liu; Chao Xiong; Yuanyuan Li; Wei Xia; Shunqing Xu; Youjie Wang; Aifen Zhou. 2020. "Association of prenatal exposure to rare earth elements with newborn mitochondrial DNA content: Results from a birth cohort study." Environment International 143, no. : 105863.
BackgroundThe coronavirus disease 2019 (Covid-19) spreads rapidly around the world.ObjectiveTo evaluate the association between comorbidities and the risk of death in patients with COVID-19, and to further explore potential sex-specific differences.MethodsWe analyzed the data from 18,465 laboratory-confirmed cases that completed an epidemiological investigation in Hubei Province as of February 27, 2020. Information on death was obtained from the Infectious Disease Information System. The Cox proportional hazards model was used to estimate the association between comorbidities and the risk of death in patients with COVID-19.ResultsThe median age for COVID-19 patients was 50.5 years. 8828(47.81%) patients were females. Severe cases accounted for 20.11% of the study population. As of March 7, 2020, a total of 919 cases deceased from COVID-19 for a fatality rate of 4.98%. Hypertension (13.87%), diabetes (5.53%), and cardiovascular and cerebrovascular diseases (CBVDs) (4.45%) were the most prevalent comorbidities, and 27.37% of patients with COVID-19 reported having at least one comorbidity. After adjustment for age, gender, address, and clinical severity, patients with hypertension (HR 1.55, 95%CI 1.35-1.78), diabetes (HR 1.35, 95%CI 1.13-1.62), CBVDs (HR 1.70, 95%CI 1.43-2.02), chronic kidney diseases (HR 2.09, 95%CI 1.47-2.98), and at least two comorbidities (HR 1.84, 95%CI 1.55-2.18) had significant increased risks of death. And the association between diabetes and the risk of death from COVID-19 was prominent in women (HR 1.69, 95%CI 1.27-2.25) than in men (HR 1.16, 95%CI 0.91-1.46) (P for interaction = 0.036).ConclusionAmong laboratory-confirmed cases of COVID-19 in Hubei province, China, patients with hypertension, diabetes, CBVDs, chronic kidney diseases were significantly associated with increased risk of death. The association between diabetes and the risk of death tended to be stronger in women than in men. Clinicians should increase their awareness of the increased risk of death in COVID-19 patients with comorbidities.
Mingyang Wu; Shuqiong Huang; Jun Liu; Yanling Shu; Yinbo Luo; Lulin Wang; Mingyan Li; Youjie Wang. Association between comorbidities and the risk of death in patients with COVID-19: sex-specific differences. 2020, 1 .
AMA StyleMingyang Wu, Shuqiong Huang, Jun Liu, Yanling Shu, Yinbo Luo, Lulin Wang, Mingyan Li, Youjie Wang. Association between comorbidities and the risk of death in patients with COVID-19: sex-specific differences. . 2020; ():1.
Chicago/Turabian StyleMingyang Wu; Shuqiong Huang; Jun Liu; Yanling Shu; Yinbo Luo; Lulin Wang; Mingyan Li; Youjie Wang. 2020. "Association between comorbidities and the risk of death in patients with COVID-19: sex-specific differences." , no. : 1.
The aim of our study was to investigate the relationship between maternal age at menarche and newborn telomere length which has been linked to lifespan and many age-related diseases. There were 734 mother-newborn pairs recruited from Wuhan Children’s Hospital Wuhan, Hubei Province, China. Age at menarche was self-reported and categorized into three groups (≤ 12 years, 13 years, and ≥ 14 years). Telomere length in cord blood was measured using quantitative real-time polymerase chain reaction and expressed as the ratio of telomere copy number to single-copy gene number (T/S). The mean age at menarche of 734 mothers was 13.1 (± 1.1) years and the adjusted geometric means in the T/S of newborn telomeres in the three groups were 0.693, 0.721, and 0.748 respectively. Earlier age at menarche (≤ 12 years), compared with later age at menarche ≥ 14 years, was significantly associated with 7.32% (95% CI − 13.70%, − 0.23%) shorter telomere length in offspring after adjusting for potential confounders. Conclusion: Mothers with earlier age at menarche were more likely to give birth newborn with shorter telomere length. Our study provides evidences for the effect of earlier menarche on fetal telomere programming in offspring.
Lulin Wang; Lulu Song; Bingqing Liu; Lina Zhang; Mingyang Wu; Wei Xia; Yuanyuan Li; Chao Xiong; Zhongqiang Cao; Shunqing Xu; Bin Zhang; Yaohua Tian; Youjie Wang. Earlier maternal menarche is associated with shorter newborn telomere length. European Journal of Pediatrics 2020, 179, 1507 -1513.
AMA StyleLulin Wang, Lulu Song, Bingqing Liu, Lina Zhang, Mingyang Wu, Wei Xia, Yuanyuan Li, Chao Xiong, Zhongqiang Cao, Shunqing Xu, Bin Zhang, Yaohua Tian, Youjie Wang. Earlier maternal menarche is associated with shorter newborn telomere length. European Journal of Pediatrics. 2020; 179 (10):1507-1513.
Chicago/Turabian StyleLulin Wang; Lulu Song; Bingqing Liu; Lina Zhang; Mingyang Wu; Wei Xia; Yuanyuan Li; Chao Xiong; Zhongqiang Cao; Shunqing Xu; Bin Zhang; Yaohua Tian; Youjie Wang. 2020. "Earlier maternal menarche is associated with shorter newborn telomere length." European Journal of Pediatrics 179, no. 10: 1507-1513.
Context Higher blood glucose level during gestational periods has been consistently associated with increased risk of adverse birth outcomes. Evidence regarding the association between higher glycated hemoglobin A1c (HbA1c) within the normal range and adverse birth outcomes is limited. Objective We aimed to examine the association between HbA1c within the normal range and the risk of adverse birth outcomes. Design and Setting The data were abstracted from the Information System of Guangdong Women and Children Hospital, China, from September 2014 to March 2018. Patients A total of 5658 pregnant women with normal gestational HbA1c were included in this analysis. Main Outcome Measures The adverse birth outcomes include preterm birth, macrosomia, and large for gestational age (LGA). Results Among 5658 subjects, the rates of preterm birth, macrosomia, and LGA were 4.6% (261/5658), 3.5% (200/5658), and 5.7% (325/5658), respectively. The results of multivariate logistic regression model showed that each 1% increase in maternal HbA1c was positively associated with increased risks of preterm birth (OR 1.58; 95% CI, 1.08-2.31), macrosomia (OR 1.70; 95% CI, 1.10-2.64), and LGA (OR 1.38; 95% CI, 0.98-1.96). The association between gestational HbA1c and preterm birth was more evident among women with prepregnancy body mass index (BMI) ≤ 24 kg/m2. Conclusions Gestational higher HbA1c level within the normal range is an independent risk factor for preterm birth, macrosomia, and LGA. Intervention for reducing HbAc1 may help to prevent adverse birth outcomes.
Jianing Bi; Cunwei Ji; Yuntao Wu; Mingyang Wu; Yunyun Liu; Lulu Song; Shikha Upadhyaya Khatiwada; Senbei Yang; Bing Li; Youjie Wang; Li Wu. Association Between Maternal Normal Range HbA1c Values and Adverse Birth Outcomes. The Journal of Clinical Endocrinology & Metabolism 2020, 105, e2185 -e2191.
AMA StyleJianing Bi, Cunwei Ji, Yuntao Wu, Mingyang Wu, Yunyun Liu, Lulu Song, Shikha Upadhyaya Khatiwada, Senbei Yang, Bing Li, Youjie Wang, Li Wu. Association Between Maternal Normal Range HbA1c Values and Adverse Birth Outcomes. The Journal of Clinical Endocrinology & Metabolism. 2020; 105 (6):e2185-e2191.
Chicago/Turabian StyleJianing Bi; Cunwei Ji; Yuntao Wu; Mingyang Wu; Yunyun Liu; Lulu Song; Shikha Upadhyaya Khatiwada; Senbei Yang; Bing Li; Youjie Wang; Li Wu. 2020. "Association Between Maternal Normal Range HbA1c Values and Adverse Birth Outcomes." The Journal of Clinical Endocrinology & Metabolism 105, no. 6: e2185-e2191.
Summary Background Growing evidence suggested that lifestyle factors including dietary habits may influence the telomere length which is a reliable marker of biological aging and predictor for chronic diseases. However, the role of dietary selenium intake in telomere length maintenance is rarely examined. Objective We aimed to test the relationship between dietary selenium intake and telomere length among middle-aged and older adults in America. Methods A total of 3194 United States adults older than 45 years old were extracted from the National Health and Nutrition Examination Survey (NHANES) in 1999–2000 and 2001–2002. Leukocyte telomere length was measured using the quantitative real-time polymerase chain reaction (qPCR). Dietary selenium intake was assessed by a trained interviewer using 24-h dietary recall method. Generalized linear models were performed to evaluate the association of dietary selenium intake with telomere length. The restricted cubic spline analysis was used to further explore the nonlinear dose–response relationship between dietary selenium intake and telomere length. Results After adjusting potential confounders, every 20 μg increase in dietary selenium intake was associated with 0.42% (95% CI: 0.02%, 0.82%) longer telomere length in all participants. In the subgroup analyses, dietary selenium intake was related to longer telomere length in females (Percentage change: 0.87%; 95% CI: 0.26%, 1.49%) and non-obese participants (Percentage change: 0.53%; 95% CI: 0.04%, 1.02%), but not in males (Percentage change: 0.04%; 95% CI: −0.49%, 0.57%) and obese participants (Percentage change: 0.21%; 95% CI: −0.47%, 0.91%). The restricted cubic spline analysis showed a linear association between dietary selenium intake and telomere length. Conclusions This study indicated that the increased dietary selenium intake was associated with longer telomere length among middle-aged and older adults in America. These findings require further corroboration from future prospective studies.
Yanling Shu; Mingyang Wu; Senbei Yang; Youjie Wang; Huawen Li. Association of dietary selenium intake with telomere length in middle-aged and older adults. Clinical Nutrition 2020, 39, 3086 -3091.
AMA StyleYanling Shu, Mingyang Wu, Senbei Yang, Youjie Wang, Huawen Li. Association of dietary selenium intake with telomere length in middle-aged and older adults. Clinical Nutrition. 2020; 39 (10):3086-3091.
Chicago/Turabian StyleYanling Shu; Mingyang Wu; Senbei Yang; Youjie Wang; Huawen Li. 2020. "Association of dietary selenium intake with telomere length in middle-aged and older adults." Clinical Nutrition 39, no. 10: 3086-3091.
Arsenic (As) is a widely distributed environmental chemical with potentially different toxicities. However, little is known about the impact of maternal As exposure on newborn mitochondrial DNA copy number (mtDNAcn), which may lie on the pathway linking As exposure to adverse health impacts. We aimed to explore whether maternal As exposure was associated with newborn mtDNAcn. We conducted a birth cohort study of 762 mother-infant pairs in Wuhan, China, 2013–2015. Cord blood mtDNAcn was determined using qPCR. Maternal urinary As levels in each trimester were quantified by ICP-MS. Multiple informant models were used to examine the associations of repeated urinary As levels with cord blood mtDNAcn. The median urinary As levels in the first, second, and third trimesters were 17.2 μg/L, 16.0 μg/L, and 17.0 μg/L, respectively. In the multivariate model, each doubling increase in the first-trimester urinary As level was associated with a 6.6% (95% CI: −12.4%, −0.5%) decrease in cord blood mtDNAcn. The highest versus lowest quintile of first-trimester urinary As level was associated with a 19.0% (95% CI: −32.9%, −2.2%) lower cord blood mtDNAcn. No significant associations of urinary As levels in the second and third trimesters with cord blood mtDNAcn were observed. The inverse relationship between first-trimester urinary As level and cord blood mtDNAcn was more pronounced among female infants. First-trimester As exposure was related to decreased cord blood mtDNAcn. The potential health impacts of decreased mtDNAcn in early life need to be further clarified.
Lulu Song; Bingqing Liu; Lulin Wang; Mingyang Wu; Lina Zhang; Yunyun Liu; Jianing Bi; Senbei Yang; Bin Zhang; Wei Xia; Shunqing Xu; Ruoling Chen; Zhongqiang Cao; Youjie Wang. Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China. Chemosphere 2019, 243, 125335 .
AMA StyleLulu Song, Bingqing Liu, Lulin Wang, Mingyang Wu, Lina Zhang, Yunyun Liu, Jianing Bi, Senbei Yang, Bin Zhang, Wei Xia, Shunqing Xu, Ruoling Chen, Zhongqiang Cao, Youjie Wang. Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China. Chemosphere. 2019; 243 ():125335.
Chicago/Turabian StyleLulu Song; Bingqing Liu; Lulin Wang; Mingyang Wu; Lina Zhang; Yunyun Liu; Jianing Bi; Senbei Yang; Bin Zhang; Wei Xia; Shunqing Xu; Ruoling Chen; Zhongqiang Cao; Youjie Wang. 2019. "Exposure to arsenic during pregnancy and newborn mitochondrial DNA copy number: A birth cohort study in Wuhan, China." Chemosphere 243, no. : 125335.
Prior studies have suggested exposure to heavy metals and endocrine disrupting chemicals could disturb the homeostasis of thyroid stimulating hormone (TSH), but no epidemiology study concerning the influence of rare earth elements (REE) exposure during pregnancy on neonatal TSH levels. The present study aimed to investigate the relationships between prenatal REE exposure and neonatal TSH levels. A total of 7367 pregnant women were recruited from Wuhan Children’s Hospital between September 2012 and October 2014 in Wuhan, China. Urinary concentrations of cerium (Ce), and ytterbium (Yb) were measured by inductively coupled plasma mass spectrometry (ICP-MS). Immunofluorescence assay was used to detect neonatal TSH levels. The associations between REE exposure and neonatal TSH levels were evaluated using multivariate linear regression models. The geometric means of maternal urinary Ce and Yb concentrations were 0.060 μg/g creatinine and 0.025 μg/g creatinine, respectively. The results showed that per doubling of maternal urinary Ce and Yb were associated with 4.07% (95% CI: −5.80%, −2.31%), 5.13% (95% CI: −6.93%, −3.30%) decreased neonatal TSH levels respectively in the adjusted model. Sex stratified analysis demonstrated that the decreased neonatal TSH levels were observed both in male infants and female infants, and the decrease was greater in male infants in urinary Ce. There were no significant interactions between maternal urinary Ce, Yb and infant sex (Ce: P for interaction = 0.173, Yb: P for interaction = 0.967). Our findings demonstrated that increased maternal urinary Ce and Yb were associated with decreased neonatal TSH levels. Further researches from different populations are warranted to verify the association and to explore the mechanisms.
Yunyun Liu; Mingyang Wu; Lina Zhang; Jianing Bi; Lulu Song; Lulin Wang; Bingqing Liu; Aifen Zhou; Zhongqiang Cao; Chao Xiong; Senbei Yang; Shunqing Xu; Wei Xia; Yuanyuan Li; Youjie Wang. Prenatal exposure of rare earth elements cerium and ytterbium and neonatal thyroid stimulating hormone levels: Findings from a birth cohort study. Environment International 2019, 133, 105222 .
AMA StyleYunyun Liu, Mingyang Wu, Lina Zhang, Jianing Bi, Lulu Song, Lulin Wang, Bingqing Liu, Aifen Zhou, Zhongqiang Cao, Chao Xiong, Senbei Yang, Shunqing Xu, Wei Xia, Yuanyuan Li, Youjie Wang. Prenatal exposure of rare earth elements cerium and ytterbium and neonatal thyroid stimulating hormone levels: Findings from a birth cohort study. Environment International. 2019; 133 ():105222.
Chicago/Turabian StyleYunyun Liu; Mingyang Wu; Lina Zhang; Jianing Bi; Lulu Song; Lulin Wang; Bingqing Liu; Aifen Zhou; Zhongqiang Cao; Chao Xiong; Senbei Yang; Shunqing Xu; Wei Xia; Yuanyuan Li; Youjie Wang. 2019. "Prenatal exposure of rare earth elements cerium and ytterbium and neonatal thyroid stimulating hormone levels: Findings from a birth cohort study." Environment International 133, no. : 105222.
To evaluate the status of elevated blood pressure in Chinese children and adolescents, and identify potential influence factors. We searched PubMed, the Web of science, the WanFang, the VIP, and the CNKI to identify articles that were published from Jan 1, 1997, to May 30, 2019. We used random effects models to estimate the pooled prevalence of elevated blood pressure, and heterogeneity among the studies was assessed with Cochran’s Q statistic. The potential source of heterogeneity was explored by meta-regression and subgroup comparisons using Q test based on ANOVA. Fifty-nine studies were included in the qualitative synthesis and the prevalence of elevated blood pressure ranged from 2.2 to 26.4%. The meta-analysis included 25 studies (341,281 participants), and the pooled prevalence of elevated blood pressure was 9.8% (95% CI 7.9, 11.9). The prevalence of elevated blood pressure in the obese children (34.1%, 95% CI 26.9, 41.7) and overweight children (15.5%, 95% CI 10.1, 21.7) was much higher than that in the normal or underweight children (5.0%, 95% CI 2.4, 8.4). Fluctuating trends in the prevalence of elevated blood pressure both in the total sample of Chinese children and adolescents and in each subgroup were observed from 2007 to 2014. Our study showed that prevalence of elevated blood pressure in children and adolescents in China was in the medium level in the world. Primary prevention for childhood hypertension should be implemented and focus on weight control and healthy lifestyle habits.
Lulin Wang; Lulu Song; Bingqing Liu; Lina Zhang; Mingyang Wu; Zhongqiang Cao; Youjie Wang. Trends and Status of the Prevalence of Elevated Blood Pressure in Children and Adolescents in China: a Systematic Review and Meta-analysis. Current Hypertension Reports 2019, 21, 88 .
AMA StyleLulin Wang, Lulu Song, Bingqing Liu, Lina Zhang, Mingyang Wu, Zhongqiang Cao, Youjie Wang. Trends and Status of the Prevalence of Elevated Blood Pressure in Children and Adolescents in China: a Systematic Review and Meta-analysis. Current Hypertension Reports. 2019; 21 (11):88.
Chicago/Turabian StyleLulin Wang; Lulu Song; Bingqing Liu; Lina Zhang; Mingyang Wu; Zhongqiang Cao; Youjie Wang. 2019. "Trends and Status of the Prevalence of Elevated Blood Pressure in Children and Adolescents in China: a Systematic Review and Meta-analysis." Current Hypertension Reports 21, no. 11: 88.
BackgroundCigarette smoking is associated with shorter telomere lengths in adults, but evidence on the effect of prenatal tobacco exposure is limited. We aimed to investigate the association between prenatal second-hand smoke exposure and newborn telomere length.MethodsWe recruited 762 mother–newborn pairs from Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital) between November 2013 and March 2015. Information on second-hand smoke exposure was obtained via questionnaires. Relative telomere length was measured in DNA extracted from umbilical cord blood. We used linear regression to assess the associations between prenatal second-hand smoke exposure and newborn telomere length.ResultsIn the fully adjusted model, prenatal second-hand smoke exposure was associated with 9.7% shorter newborn telomere length (percent difference: −9.7%; 95% confidence interval (CI): −15.0, −4.0). The estimate for boys was lower (percent difference: −10.9%; 95% CI: −18.6, −2.5) than that for girls (percent difference: −8.5%; 95% CI: −15.8, −0.5), but the interaction term between newborn sex and prenatal second-hand smoke was not significant (P = 0.751).ConclusionsThis study demonstrated that prenatal second-hand smoke exposure may be a preventable risk factor for accelerated biological aging in the intrauterine stage, and further suggested possible sex differences in the susceptibility to prenatal second-hand smoke.
Bingqing Liu; Lulu Song; Lina Zhang; Mingyang Wu; Lulin Wang; Zhongqiang Cao; Chao Xiong; Bin Zhang; Yuanyuan Li; Wei Xia; Shunqing Xu; Youjie Wang. Prenatal second-hand smoke exposure and newborn telomere length. Pediatric Research 2019, 87, 1081 -1085.
AMA StyleBingqing Liu, Lulu Song, Lina Zhang, Mingyang Wu, Lulin Wang, Zhongqiang Cao, Chao Xiong, Bin Zhang, Yuanyuan Li, Wei Xia, Shunqing Xu, Youjie Wang. Prenatal second-hand smoke exposure and newborn telomere length. Pediatric Research. 2019; 87 (6):1081-1085.
Chicago/Turabian StyleBingqing Liu; Lulu Song; Lina Zhang; Mingyang Wu; Lulin Wang; Zhongqiang Cao; Chao Xiong; Bin Zhang; Yuanyuan Li; Wei Xia; Shunqing Xu; Youjie Wang. 2019. "Prenatal second-hand smoke exposure and newborn telomere length." Pediatric Research 87, no. 6: 1081-1085.
Chunhui Li; Yang Peng; Bin Zhang; Weiying Ji; Li Li; Jianhua Gong; Wei Xia; Yuanyuan Li; Shuna Jin; Ranran Song; Youjie Wang; Shunqing Xu. Birth weight prediction models for the different gestational age stages in a Chinese population. Scientific Reports 2019, 9, 1 .
AMA StyleChunhui Li, Yang Peng, Bin Zhang, Weiying Ji, Li Li, Jianhua Gong, Wei Xia, Yuanyuan Li, Shuna Jin, Ranran Song, Youjie Wang, Shunqing Xu. Birth weight prediction models for the different gestational age stages in a Chinese population. Scientific Reports. 2019; 9 (1):1.
Chicago/Turabian StyleChunhui Li; Yang Peng; Bin Zhang; Weiying Ji; Li Li; Jianhua Gong; Wei Xia; Yuanyuan Li; Shuna Jin; Ranran Song; Youjie Wang; Shunqing Xu. 2019. "Birth weight prediction models for the different gestational age stages in a Chinese population." Scientific Reports 9, no. 1: 1.
Prenatal exposure to thallium is related to adverse birth outcomes. However, little is known about the effects of prenatal exposure to thallium on the mitochondrial DNA copy number (mtDNAcn) in newborns; such knowledge might reveal a potential mechanism linking maternal thallium exposure and adverse birth outcomes. To investigate the trimester-specific associations of maternal thallium exposure with cord blood leukocyte mtDNAcn. A total of 746 pregnant women with trimester-specific urinary samples and cord blood samples were recruited from Wuhan Children Hospital between November 2013 and March 2015 in Wuhan City, China. The concentration of thallium in maternal urine was quantified using inductively coupled plasma mass spectrometry (ICP-MS). Cord blood leukocyte mtDNAcn was measured by real-time quantitative polymerase chain reaction (qPCR). Trimester-specific associations of specific gravity (SG)–adjusted urinary thallium concentrations with mtDNAcn were estimated using a multiple informant model. The geometric mean value of maternal urinary thallium was 0.34 μg/L, 0.36 μg/L, and 0.34 μg/L for the first, second, and third trimesters, respectively. Prenatal exposure to thallium during the first trimester, rather than during the second or the third trimester, was identified as negatively related to mtDNAcn. The multiple informant model showed a 10.4% lower level of mtDNAcn with each doubling increase of thallium levels (95% CI, −16.4%, −3.9%; P = 0.002). The observed associations were stronger among female newborns and among newborns born to older mothers. The present study revealed a significant negative association between maternal thallium exposure during early pregnancy and cord blood leukocyte mtDNAcn in Chinese newborns, pointing to the important role of mitochondria as a target of thallium toxicity in early pregnancy.
Mingyang Wu; Yanling Shu; Lulu Song; Bingqing Liu; Lina Zhang; Lulin Wang; Yunyun Liu; Jianing Bi; Chao Xiong; Zhongqiang Cao; Shunqing Xu; Wei Xia; Yuanyuan Li; Youjie Wang. Prenatal exposure to thallium is associated with decreased mitochondrial DNA copy number in newborns: Evidence from a birth cohort study. Environment International 2019, 129, 470 -477.
AMA StyleMingyang Wu, Yanling Shu, Lulu Song, Bingqing Liu, Lina Zhang, Lulin Wang, Yunyun Liu, Jianing Bi, Chao Xiong, Zhongqiang Cao, Shunqing Xu, Wei Xia, Yuanyuan Li, Youjie Wang. Prenatal exposure to thallium is associated with decreased mitochondrial DNA copy number in newborns: Evidence from a birth cohort study. Environment International. 2019; 129 ():470-477.
Chicago/Turabian StyleMingyang Wu; Yanling Shu; Lulu Song; Bingqing Liu; Lina Zhang; Lulin Wang; Yunyun Liu; Jianing Bi; Chao Xiong; Zhongqiang Cao; Shunqing Xu; Wei Xia; Yuanyuan Li; Youjie Wang. 2019. "Prenatal exposure to thallium is associated with decreased mitochondrial DNA copy number in newborns: Evidence from a birth cohort study." Environment International 129, no. : 470-477.