In this study, we developed a novel and facile electrochemical aptasensor for β-amyloid (Aβ) oligomer detection based on metal–organic frameworks (MOFs) as signal probes.

Metal–organic frameworks (MOFs), as a class of crystalline hybrid architectures, consist of metal ions and organic ligands and have displayed great potential in luminescent sensing applications due to their tunable structures and unique photophysical properties. Until now, many studies have been reported on the development of MOF-based luminescent sensors, which can be classified into two major categories: MOF chemosensors based on reversible host–guest interactions and MOF chemodosimeters based on the irreversible reactions between targets with a probe. In this review, we summarize the recently developed luminescent MOF-based chemodosimeters for various analytes, including H₂S, HClO, biothiols, fluoride ions, redox-active biomolecules, Hg²⁺, and CN⁻. In addition, some remaining challenges and future perspectives in this area are also discussed.