Dr. Daniele Bottai obtained his Ph.D. in Basic Neuroscience in 1995 at the University of Pisa. He moved to McGill University to work in Drapeau’s and Dunn’s Labs for his first postdoctoral training and then to Peter Seeburg's Lab at Max Plank Institute in Heidelberg for his second postdoctoral training in 1997. In 2002 he returned to Italy to work in Angelo Vescovi’s Lab. He obtained an Assistant Professor position at the University of Milan in 2006 and received his tenure in 2009. His major interest has always been neuroscience. In the last 20 years, he has been involved in the study of stem cells of various origins such as neural stem cells, mesenchymal stem cells, and embryonic or induced pluripotent stem cells as tools for the study of neurological diseases and their therapy. Lately, he has developed a strong interest in the effects of motor deprivation on the interactions between muscle and neurogenic regions. Since the patients affected by neuromuscular diseases have a reduction in motor activity, he hypothesizes that the limitation in motor activity could exacerbate the effect of the disease itself. Moreover, other categories of individuals that undergo a reduction in muscular activity are astronauts who are subjected to a reduction in gravitational force. Dr. Bottai now teaches physiology at the Pharmacy and Specialty School of Medical Pharmacy. Moreover, he has supervised many students for their undergraduate and Ph.D. studies.