The function of sensory hair cells of the cochlea and vestibular organs depends on an influx of K⁺ through apical mechanosensitive ion channels and its subsequent removal over their basolateral membrane. The KCNQ4 (K_v7.4) K⁺ channel, which is mutated in DFNA2 human hearing loss, is expressed in the basal membrane of cochlear outer hair cells where it may mediate K⁺ efflux. Like the related K⁺ channel KCNQ5 (K_v7.5), KCNQ4 is also found at calyx terminals ensheathing type I vestibular hair cells where it may be localized pre- or postsynaptically. Making use of Kcnq4^−/− mice lacking KCNQ4, as well as Kcnq4^dn/dn and Kcnq5^dn/dn mice expressing dominant negative channel mutants, we now show unambiguously that in adult mice both channels reside in postsynaptic calyx-forming neurons, but cannot be detected in the innervated hair cells. Accordingly, whole cell currents of vestibular hair cells did not differ between genotypes. Neither Kcnq4^−/−, Kcnq5^dn/dn nor Kcnq4^−/−/Kcnq5^dn/dn double mutant mice displayed circling behavior found with severe vestibular impairment. However, a milder form of vestibular dysfunction was apparent from altered vestibulo-ocular reflexes in Kcnq4^−/−/Kcnq5^dn/dn and Kcnq4^−/− mice. The larger impact of KCNQ4 may result from its preferential expression in central zones of maculae and cristae, which are innervated by phasic neurons that are more sensitive than the tonic neurons present predominantly in the surrounding peripheral zones where KCNQ5 is found. The impact of postsynaptic KCNQ4 on vestibular function may be related to K⁺ removal and modulation of synaptic transmission.

Public markets were once essential parts of the cityscape and they are becoming so again. Markets serve several purposes, social, political, and economic, and so planners interested in multipurpose tools for development will be interested in public markets. Markets can help achieve a variety of goals including place-making, employment, and entrepreneurship. This article focuses on markets as tools of business incubation. Archival data and literature shows how important markets once were to cities. Ethnographically collected data from Chicago's Maxwell Street market illustrates the individual and structural factors that account for businesses created at the market. Rural and urban markets are emerging or being rehabilitated all over the country — this research helps planners understand the history of markets, their multi-disciplinary nature, and the circumstances of people creating businesses at markets.

This article summarizes what we know about marketplaces in the United States, relates that knowledge to a research agenda on the subject, and makes suggestions for planning practice. This review accomplishes these three goals beginning with a historical review of marketplaces, focused mostly on the United States. The research literature on marketplaces is reviewed from political, economic, social, and health perspectives with suggestions for further basic and applied research. In short, the article shows how marketplaces were once tools of nascent planning and public policy, describes the reasons they should be again, and shows how planners and policy makers can advance public purposes through markets.

Problem, research strategy, and findings: Municipalities across the United States are gradually recognizing urban agriculture as an integral part of planning, land use, and zoning ordinances. We review the literature on the regulation of urban agriculture at a moment when policy and regulatory vacuums exist and the acceptance and integration of urban agriculture is uneven. We review the current regulatory practices of 40 metropolitan and 40 micropolitan municipalities in the 4 U.S. Census regions. We find that municipalities are filling policy vacuums by adopting enabling ordinances (zoning ordinances, land use designations, resolutions), regulations on urban agriculture production (backyard animals, built structures, practitioner responsibility), and fiscal policy instruments (restrictions on sales of agricultural products, tax abatement, urban agriculture fees). Our findings support local planning practitioners in filling regulatory gaps, practitioners of urban agriculture in seeking how it’s done elsewhere, and researchers in discerning new applied and basic research projects. We identify 3 principal knowledge gaps: Planners need a complete typology of regulatory possibilities; a better understanding of how local, state, and federal legislations constrain or enable urban agriculture; and empirical evidence of the economic, social, and environmental impacts of urban agriculture. Takeaway for practice: Planners should assess existing urban agricultural practices and consider which regulatory frameworks best support multiple local goals, incorporating a concern with urban agriculture into ongoing activities, deploying existing or innovative land use tools, facilitating institutional cooperation, and promoting inclusive decision making and community engagement.

Objectives. Compared to other groups, Mexican American women screen less frequently for cervical and breast cancer. The most significant barriers reported by previous researchers include not having a usual source of care, lacking health insurance and English-language difficulties. In this paper we document and examine the factors associated with disparities in cancer screening between border and non-border residents by language of interview (Spanish or English) among Texas Hispanic women. We hypothesize that, controlling for socioeconomic and demographic characteristics, border residents are more likely to utilize screening services than non-border residents because of the greater presence of bilingual services in border counties. Design. We follow the framework of the Behavioral Model for Vulnerable Populations proposed by Gelberg et al. (Health Services Research, vol. 34, no. 6, pp. 1273–1302, 2000). This model conceptualizes use of health care as an outcome of the interplay of predisposing, enabling and need factors and recognizes that vulnerable groups face additional barriers to health care utilization. Data come from the 2000, 2002 and 2004 Texas Behavioral Risk Factor Surveillance surveys. Results. Group differences in cancer screenings are explained largely by socioeconomic characteristics and structural barriers to access. The significance of language of interview and of border residence disappear after controlling for factors such as health insurance, income and a usual source of care. Conclusion. Women who selected to be interviewed in Spanish were less likely to report age-appropriate cancer examinations, health insurance and a regular health care provider than those who selected to be interviewed in English. Disparities in cancer screenings among vulnerable Hispanic populations could be reduced by promoting the establishment of a regular health care provider.

EDQ introduces a new format to the Forum section in this issue. Periodically an article is submitted to us that raises important policy or methodological issues that have generated sharp responses from external reviewers. We believe that the debate that has taken place between the authors and reviewers is of such importance that we have then solicited people to comment on the article. Controversy on Maxwell Street raises the issue of the marriage of anthropologic and economic techniques in economic development analysis. We hope that you find this debate as stimulating as we did. Controversy on Maxwell Street began when Morales, Balkin, and Persky submitted their article, “The Value of Benefits of a Public Street Market: The Case of Maxwell Street.” We then requested that Rhoda H. Halperin and Wim Wiewel respond. Following their responses is a rejoinder by the authors. Chicago's Maxwell Street Market was among the oldest open-air public markets in the United States. The market was closed in August 1994 and a smaller alternative market was opened on Canal Street. This article estimates monetary losses resulting from the closure of the market. First, the authors briefly discuss the markets history, followed by a review of the literature on the informal economy. The problem of quantifying the value of street vending is addressed by combining ethnographic and economic analytical methods. Ethnography is introduced in the article's third section. The authors demonstrate the usefulness of merging ethnographic and economic analysis by estimating monetary losses to vendors and consumers as a result of changes in the market's governance and location.