Liu Guangzhong

Dr. Liu Guangzhong

orcid

Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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Journal Article
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DQdalei qiao
dalei qiao
LGLiu Guangzhong
Liu Guangzhong
TLTaizhi Lv
Taizhi Lv
WLWei Li
Wei Li
JZJuan Zhang
Juan Zhang
The primary task of marine surveillance is to construct a perfect marine situational awareness (MSA) system that serves to safeguard national maritime rights and interests and to maintain blue homeland security. Progress in maritime wireless communication, developments in artificial intelligence, and automation of marine turbines together imply that intelligent shipping is inevitable in future global shipping. Computer vision-based situational awareness provides visual semantic information to human beings that approximates eyesight, which makes it likely to be widely used in the field of intelligent marine transportation. We describe how we combined the visual perception tasks required for marine surveillance with those required for intelligent ship navigation to form a marine computer vision-based situational awareness complex and investigated the key technologies they have in common. Deep learning was a prerequisite activity. We summarize the progress made in four aspects of current research: full scene parsing of an image, target vessel re-identification, target vessel tracking, and multimodal data fusion with data from visual sensors. The paper gives a summary of research to date to provide background for this work and presents brief analyses of existing problems, outlines some state-of-the-art approaches, reviews available mainstream datasets, and indicates the likely direction of future research and development. As far as we know, this paper is the first review of research into the use of deep learning in situational awareness of the ocean surface. It provides a firm foundation for further investigation by researchers in related fields.


28 February 2021 in Genes
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Lu ZhangLu Zhang
Lu Zhang
XQXinyi Qin
Xinyi Qin
MLMin Liu
Min Liu
ZXZiwei Xu
Ziwei Xu
LGLiu Guangzhong
Liu Guangzhong
As a prevalent existing post-transcriptional modification of RNA, N6-methyladenosine (m6A) plays a crucial role in various biological processes. To better radically reveal its regulatory mechanism and provide new insights for drug design, the accurate identification of m6A sites in genome-wide is vital. As the traditional experimental methods are time-consuming and cost-prohibitive, it is necessary to design a more efficient computational method to detect the m6A sites. In this study, we propose a novel cross-species computational method DNN-m6A based on the deep neural network (DNN) to identify m6A sites in multiple tissues of human, mouse and rat. Firstly, binary encoding (BE), tri-nucleotide composition (TNC), enhanced nucleic acid composition (ENAC), K-spaced nucleotide pair frequencies (KSNPFs), nucleotide chemical property (NCP), pseudo dinucleotide composition (PseDNC), position-specific nucleotide propensity (PSNP) and position-specific dinucleotide propensity (PSDP) are employed to extract RNA sequence features which are subsequently fused to construct the initial feature vector set. Secondly, we use elastic net to eliminate redundant features while building the optimal feature subset. Finally, the hyper-parameters of DNN are tuned with Bayesian hyper-parameter optimization based on the selected feature subset. The five-fold cross-validation test on training datasets show that the proposed DNN-m6A method outperformed the state-of-the-art method for predicting m6A sites, with an accuracy (ACC) of 73.58–83.38% and an area under the curve (AUC) of 81.39–91.04%. Furthermore, the independent datasets achieved an ACC of 72.95–83.04% and an AUC of 80.79–91.09%, which shows an excellent generalization ability of our proposed method.

25 August 2021 in Computational and Mathematical Methods in Medicine
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Journal Article
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Lu ZhangLu Zhang
Lu Zhang
XQXinyi Qin
Xinyi Qin
MLMin Liu
Min Liu
LGLiu Guangzhong
Liu Guangzhong
YRYuxiao Ren
Yuxiao Ren
As one of the most prevalent posttranscriptional modifications of RNA, N7-methylguanosine (m7G) plays an essential role in the regulation of gene expression. Accurate identification of m7G sites in the transcriptome is invaluable for better revealing their potential functional mechanisms. Although high-throughput experimental methods can locate m7G sites precisely, they are overpriced and time-consuming. Hence, it is imperative to design an efficient computational method that can accurately identify the m7G sites. In this study, we propose a novel method via incorporating BERT-based multilingual model in bioinformatics to represent the information of RNA sequences. Firstly, we treat RNA sequences as natural sentences and then employ bidirectional encoder representations from transformers (BERT) model to transform them into fixed-length numerical matrices. Secondly, a feature selection scheme based on the elastic net method is constructed to eliminate redundant features and retain important features. Finally, the selected feature subset is input into a stacking ensemble classifier to predict m7G sites, and the hyperparameters of the classifier are tuned with tree-structured Parzen estimator (TPE) approach. By 10-fold cross-validation, the performance of BERT-m7G is measured with an ACC of 95.48% and an MCC of 0.9100. The experimental results indicate that the proposed method significantly outperforms state-of-the-art prediction methods in the identification of m7G modifications.

10 November 2020 in Computational and Mathematical Methods in Medicine
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Lu ZhangLu Zhang
Lu Zhang
MLMin Liu
Min Liu
XQXinyi Qin
Xinyi Qin
LGLiu Guangzhong
Liu Guangzhong
Succinylation is an important posttranslational modification of proteins, which plays a key role in protein conformation regulation and cellular function control. Many studies have shown that succinylation modification on protein lysine residue is closely related to the occurrence of many diseases. To understand the mechanism of succinylation profoundly, it is necessary to identify succinylation sites in proteins accurately. In this study, we develop a new model, IFS-LightGBM (BO), which utilizes the incremental feature selection (IFS) method, the LightGBM feature selection method, the Bayesian optimization algorithm, and the LightGBM classifier, to predict succinylation sites in proteins. Specifically, pseudo amino acid composition (PseAAC), position-specific scoring matrix (PSSM), disorder status, and Composition of -spaced Amino Acid Pairs (CKSAAP) are firstly employed to extract feature information. Then, utilizing the combination of the LightGBM feature selection method and the incremental feature selection (IFS) method selects the optimal feature subset for the LightGBM classifier. Finally, to increase prediction accuracy and reduce the computation load, the Bayesian optimization algorithm is used to optimize the parameters of the LightGBM classifier. The results reveal that the IFS-LightGBM (BO)-based prediction model performs better when it is evaluated by some common metrics, such as accuracy, recall, precision, Matthews Correlation Coefficient (MCC), and -measure.

26 June 2019 in Electronics
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DQdalei qiao
dalei qiao
LGLiu Guangzhong
Liu Guangzhong
JZJun Zhang
Jun Zhang
QZQiangyong Zhang
Qiangyong Zhang
GWGongxing WU
Gongxing WU
FDFeng Dong
Feng Dong
It is crucial for unmanned surface vessels (USVs) to detect and track surrounding vessels in real time to avoid collisions at sea. However, the harsh maritime environment poses great challenges to multitarget tracking (MTT). In this paper, a novel tracking by detection framework that integrates the multimodel and multicue (M3C) pipeline is proposed, which aims at improving the detection and tracking performance. Regarding the multimodel, we predicted the maneuver probability of a target vessel via the gated recurrent unit (GRU) model with an attention mechanism, and fused their respective outputs as the output of a kinematic filter. We developed a hybrid affinity model based on multi cues, such as the motion, appearance, and attitude of the ego vessel in the data association stage. By using the proposed ship re-identification approach, the tracker had the capability of appearance matching via metric learning. Experimental evaluation of two public maritime datasets showed that our method achieved state-of-the-art performance, not only in identity switches (IDS) but also in frame rates.