Nan-Han Lu

Dr. Nan-Han Lu


Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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8 June 2021 in Biosensors
Verified
Journal Article
Open access
PDF file
LYLiren Yeh
Liren Yeh
WCWei-Chin Chen
Wei-Chin Chen
HCHua-Yan Chan
Hua-Yan Chan
NLNan-Han Lu
Nan-Han Lu
CWChi-Yuan Wang
Chi-Yuan Wang
TCTai-Been Chen
Tai-Been Chen
Anesthesia assessment is most important during surgery. Anesthesiologists use electrocardiogram (ECG) signals to assess the patient’s condition and give appropriate medications. However, it is not easy to interpret the ECG signals. Even physicians with more than 10 years of clinical experience may still misjudge. Therefore, this study uses convolutional neural networks to classify ECG image types to assist in anesthesia assessment. The research uses Internet of Things (IoT) technology to develop ECG signal measurement prototypes. At the same time, it classifies signal types through deep neural networks, divided into QRS widening, sinus rhythm, ST depression, and ST elevation. Three models, ResNet, AlexNet, and SqueezeNet, are developed with 50% of the training set and test set. Finally, the accuracy and kappa statistics of ResNet, AlexNet, and SqueezeNet in ECG waveform classification were (0.97, 0.96), (0.96, 0.95), and (0.75, 0.67), respectively. This research shows that it is feasible to measure ECG in real time through IoT and then distinguish four types through deep neural network models. In the future, more types of ECG images will be added, which can improve the real-time classification practicality of the deep model.

13 June 2022 in Diagnostics
Verified
Journal Article
Open access
PDF file
Guan-Hua HuangGuan-Hua Huang
Guan-Hua Huang
QFQi-Jia Fu
Qi-Jia Fu
MGMing-Zhang Gu
Ming-Zhang Gu
NLNan-Han Lu
Nan-Han Lu
KLKuo-Ying Liu
Kuo-Ying Liu
TCTai-Been Chen
Tai-Been Chen
Chest X-ray (CXR) is widely used to diagnose conditions affecting the chest, its contents, and its nearby structures. In this study, we used a private data set containing 1630 CXR images with disease labels; most of the images were disease-free, but the others contained multiple sites of abnormalities. Here, we used deep convolutional neural network (CNN) models to extract feature representations and to identify possible diseases in these images. We also used transfer learning combined with large open-source image data sets to resolve the problems of insufficient training data and optimize the classification model. The effects of different approaches of reusing pretrained weights (model finetuning and layer transfer), source data sets of different sizes and similarity levels to the target data (ImageNet, ChestX-ray, and CheXpert), methods integrating source data sets into transfer learning (initiating, concatenating, and co-training), and backbone CNN models (ResNet50 and DenseNet121) on transfer learning were also assessed. The results demonstrated that transfer learning applied with the model finetuning approach typically afforded better prediction models. When only one source data set was adopted, ChestX-ray performed better than CheXpert; however, after ImageNet initials were attached, CheXpert performed better. ResNet50 performed better in initiating transfer learning, whereas DenseNet121 performed better in concatenating and co-training transfer learning. Transfer learning with multiple source data sets was preferable to that with a source data set. Overall, transfer learning can further enhance prediction capabilities and reduce computing costs for CXR images.

9 December 2023 in Scientific Reports
Verified
Journal Article
Open access
PDF file
THTe-Li Huang
Te-Li Huang
NLNan-Han Lu
Nan-Han Lu
YHYung-Hui Huang
Yung-Hui Huang
WTWen-Hung Twan
Wen-Hung Twan
LYLi-Ren Yeh
Li-Ren Yeh
TCTai-Been Chen
Tai-Been Chen
Early detection of prostate cancer (PCa) and benign prostatic hyperplasia (BPH) is crucial for maintaining the health and well-being of aging male populations. This study aims to evaluate the performance of transfer learning with convolutional neural networks (CNNs) for efficient classification of PCa and BPH in transrectal ultrasound (TRUS) images. A retrospective experimental design was employed in this study, with 1380 TRUS images for PCa and 1530 for BPH. Seven state-of-the-art deep learning (DL) methods were employed as classifiers with transfer learning applied to popular CNN architectures. Performance indices, including sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), Kappa value, and Hindex (Youden’s index), were used to assess the feasibility and efficacy of the CNN methods. The CNN methods with transfer learning demonstrated a high classification performance for TRUS images, with all accuracy, specificity, sensitivity, PPV, NPV, Kappa, and Hindex values surpassing 0.9400. The optimal accuracy, sensitivity, and specificity reached 0.9987, 0.9980, and 0.9980, respectively, as evaluated using twofold cross-validation. The investigated CNN methods with transfer learning showcased their efficiency and ability for the classification of PCa and BPH in TRUS images. Notably, the EfficientNetV2 with transfer learning displayed a high degree of effectiveness in distinguishing between PCa and BPH, making it a promising tool for future diagnostic applications.

7 August 2023 in Healthcare
Verified
Journal Article
Open access
PDF file
JWJing-Zhe Wang
Jing-Zhe Wang
NLNan-Han Lu
Nan-Han Lu
WDWei-Chang Du
Wei-Chang Du
KLKuo-Ying Liu
Kuo-Ying Liu
SHShih Yen Hsu
Shih Yen Hsu
YHYung-Hui Huang
Yung-Hui Huang
This study focuses on overcoming challenges in classifying eye diseases using color fundus photographs by leveraging deep learning techniques, aiming to enhance early detection and diagnosis accuracy. We utilized a dataset of 6392 color fundus photographs across eight disease categories, which was later augmented to 17,766 images. Five well-known convolutional neural networks (CNNs)—efficientnetb0, mobilenetv2, shufflenet, resnet50, and resnet101—and a custom-built CNN were integrated and trained on this dataset. Image sizes were standardized, and model performance was evaluated via accuracy, Kappa coefficient, and precision metrics. Shufflenet and efficientnetb0demonstrated strong performances, while our custom 17-layer CNN outperformed all with an accuracy of 0.930 and a Kappa coefficient of 0.920. Furthermore, we found that the fusion of image features with classical machine learning classifiers increased the performance, with Logistic Regression showcasing the best results. Our study highlights the potential of AI and deep learning models in accurately classifying eye diseases and demonstrates the efficacy of custom-built models and the fusion of deep learning and classical methods. Future work should focus on validating these methods across larger datasets and assessing their real-world applicability.

10 May 2023 in Healthcare
Verified
Journal Article
Open access
PDF file
KLKuo-Hsuan Lin
Kuo-Hsuan Lin
NLNan-Han Lu
Nan-Han Lu
TOTakahide Okamoto
Takahide Okamoto
YHYung-Hui Huang
Yung-Hui Huang
KLKuo-Ying Liu
Kuo-Ying Liu
TCTai-Been Chen
Tai-Been Chen
Convolutional neural networks (CNNs) have shown promise in accurately diagnosing coronavirus disease 2019 (COVID-19) and bacterial pneumonia using chest X-ray images. However, determining the optimal feature extraction approach is challenging. This study investigates the use of fusion-extracted features by deep networks to improve the accuracy of COVID-19 and bacterial pneumonia classification with chest X-ray radiography. A Fusion CNN method was developed using five different deep learning models after transferred learning to extract image features (Fusion CNN). The combined features were used to build a support vector machine (SVM) classifier with a RBF kernel. The performance of the model was evaluated using accuracy, Kappa values, recall rate, and precision scores. The Fusion CNN model achieved an accuracy and Kappa value of 0.994 and 0.991, with precision scores for normal, COVID-19, and bacterial groups of 0.991, 0.998, and 0.994, respectively. The results indicate that the Fusion CNN models with the SVM classifier provided reliable and accurate classification performance, with Kappa values no less than 0.990. Using a Fusion CNN approach could be a possible solution to enhance accuracy further. Therefore, the study demonstrates the potential of deep learning and fusion-extracted features for accurate COVID-19 and bacterial pneumonia classification with chest X-ray radiography.

3 May 2022 in Biosensors
Verified
Journal Article
Open access
PDF file
PLPosen Lee
Posen Lee
TCTai-Been Chen
Tai-Been Chen
CLChin-Hsuan Liu
Chin-Hsuan Liu
CWChi-Yuan Wang
Chi-Yuan Wang
Guan-Hua HuangGuan-Hua Huang
Guan-Hua Huang
NLNan-Han Lu
Nan-Han Lu
Many neurological and musculoskeletal disorders are associated with problems related to postural movement. Noninvasive tracking devices are used to record, analyze, measure, and detect the postural control of the body, which may indicate health problems in real time. A total of 35 young adults without any health problems were recruited for this study to participate in a walking experiment. An iso-block postural identity method was used to quantitatively analyze posture control and walking behavior. The participants who exhibited straightforward walking and skewed walking were defined as the control and experimental groups, respectively. Fusion deep learning was applied to generate dynamic joint node plots by using OpenPose-based methods, and skewness was qualitatively analyzed using convolutional neural networks. The maximum specificity and sensitivity achieved using a combination of ResNet101 and the naïve Bayes classifier were 0.84 and 0.87, respectively. The proposed approach successfully combines cell phone camera recordings, cloud storage, and fusion deep learning for posture estimation and classification.