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Ten polyketide derivatives (1–10), including a new natural product named (E)-2,4-dihydroxy-3-methyl-6-(2-oxopent-3-en-1-yl) benzaldehyde (1), and five known diketopiperazines (11–15), were isolated from the mangrove-sediment-derived fungus Aspergillus sp. SCSIO41407. The structures of 1–15 were determined via NMR and MS spectroscopic analysis. In a variety of bioactivity screening, 3 showed weak cytotoxicity against the A549 cell line, and 2 exhibited weak antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 3, 5, and 6 showed inhibition against acetylcholinesterase (AChE) with IC50 values of 23.9, 39.9, and 18.6 μM. Compounds 11, 12, and 14 exhibited obvious inhibitory activities of lipopolysaccharide (LPS)-induced nuclear factor-κB (NF-κB) with IC50 values of 19.2, 20.9, and 8.7 μM, and they also suppressed RANKL-induced osteoclast differentiation in bone marrow macrophages cells (BMMCs), with the concentration of 5 μM. In silico molecular docking with AChE and NF-κB p65 protein were also performed to understand the inhibitory activities, and 1, 11–14 showed obvious protein/ligand-binding effects to the NF-κB p65 protein.
Jian Cai; Chunmei Chen; Yanhui Tan; Weihao Chen; Xiaowei Luo; Lianxiang Luo; Bin Yang; Yonghong Liu; Xuefeng Zhou. Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407. Molecules 2021, 26, 4851 .
AMA StyleJian Cai, Chunmei Chen, Yanhui Tan, Weihao Chen, Xiaowei Luo, Lianxiang Luo, Bin Yang, Yonghong Liu, Xuefeng Zhou. Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407. Molecules. 2021; 26 (16):4851.
Chicago/Turabian StyleJian Cai; Chunmei Chen; Yanhui Tan; Weihao Chen; Xiaowei Luo; Lianxiang Luo; Bin Yang; Yonghong Liu; Xuefeng Zhou. 2021. "Bioactive Polyketide and Diketopiperazine Derivatives from the Mangrove-Sediment-Derived Fungus Aspergillus sp. SCSIO41407." Molecules 26, no. 16: 4851.
The mangrove-sediment-derived actinomycete strain Streptomycespsammoticus SCSIO NS126 was found to have productive piericidin metabolites featuring anti-renal cell carcinoma activities. In this study, in order to explore more diverse piericidin derivatives, and therefore to discover superior anti-tumor lead compounds, the NS126 strain was further fermented at a 300-L scale under optimized fermentation conditions. As a result, eight new minor piericidin derivatives (piericidins L-R (1–7) and 11-demethyl-glucopiericidin A (8)) were obtained, along with glucopiericidin B (9). The new structures including absolute configurations were determined by spectroscopic methods coupled with experimental and calculated electronic circular dichroism. We also proposed plausible biosynthetic pathways for these unusual post-modified piericidins. Compounds 1 and 6 showed selective cytotoxic activities against OS-RC-2 cells, and 2–5 exhibited potent cytotoxicity against HL-60 cells, with IC50 values lower than 0.1 μM. The new piericidin glycoside 8 was cytotoxic against ACHN, HL-60 and K562, with IC50 values of 2.3, 1.3 and 5.5 μM, respectively. The ability to arrest the cell cycle and cell apoptosis effects induced by 1 and 6 in OS-RC-2 cells, 2 in HL-60 cells, and 8 in ACHN cells were then further investigated. This study enriched the structural diversity of piericidin derivatives and confirmed that piericidins deserve further investigations as promising anti-tumor agents.
Kunlong Li; Ziqi Su; Yongli Gao; Xiuping Lin; Xiaoyan Pang; Bin Yang; Huaming Tao; Xiaowei Luo; Yonghong Liu; Xuefeng Zhou. Cytotoxic Minor Piericidin Derivatives from the Actinomycete Strain Streptomyces psammoticus SCSIO NS126. Marine Drugs 2021, 19, 428 .
AMA StyleKunlong Li, Ziqi Su, Yongli Gao, Xiuping Lin, Xiaoyan Pang, Bin Yang, Huaming Tao, Xiaowei Luo, Yonghong Liu, Xuefeng Zhou. Cytotoxic Minor Piericidin Derivatives from the Actinomycete Strain Streptomyces psammoticus SCSIO NS126. Marine Drugs. 2021; 19 (8):428.
Chicago/Turabian StyleKunlong Li; Ziqi Su; Yongli Gao; Xiuping Lin; Xiaoyan Pang; Bin Yang; Huaming Tao; Xiaowei Luo; Yonghong Liu; Xuefeng Zhou. 2021. "Cytotoxic Minor Piericidin Derivatives from the Actinomycete Strain Streptomyces psammoticus SCSIO NS126." Marine Drugs 19, no. 8: 428.
Reported as two antirenal cell carcinoma (RCC) drug candidates, marine-derived compounds piericidin A (PA) and glucopiericidin A (GPA) exhibit hepatotoxicity in renal carcinoma xenograft mice. Proteomics and transcriptomics reveal the hepatotoxicity related with cholesterol disposition since RCC is characterized by cholesterol accumulation. PA/GPA aggravate hepatotoxicity in high-cholesterol diet (HCD)-fed mice while exhibiting no toxicity in chow diet-fed mice. High cholesterol accumulation in liver is liver X receptor (LXR)-mediated cytochrome P450 family 7 subfamily a member 1 (CYP7A1) depression and low-density lipoprotein receptor (LDLR) activation. The farnesoid X nuclear receptor (FXR) is also depressed with a downregulated target gene OSTα. Different from PA directly combined with LXRα as an inhibitor, GPA exists as a prodrug in the liver and exerts toxic effects due to transformation into PA. Surface plasmon resonance (SPR) and docking results of 17 piericidins illustrate that glycosides exert no LXRα binding activity. A longer survival time of GPA-treated mice indicates that further exploration in anti-RCC drug research should focus on reducing glycosides transformed into PA and concentrating in the kidney tumor rather than the liver for lowering the risk of hepatotoxicity.
Zhi Liang; Yulian Chen; Tanwei Gu; Jianglian She; Fahong Dai; Huanguo Jiang; Zhikun Zhan; Kunlong Li; Yonghong Liu; Xuefeng Zhou; Lan Tang. LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice. Journal of Medicinal Chemistry 2021, 64, 9943 -9959.
AMA StyleZhi Liang, Yulian Chen, Tanwei Gu, Jianglian She, Fahong Dai, Huanguo Jiang, Zhikun Zhan, Kunlong Li, Yonghong Liu, Xuefeng Zhou, Lan Tang. LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice. Journal of Medicinal Chemistry. 2021; 64 (14):9943-9959.
Chicago/Turabian StyleZhi Liang; Yulian Chen; Tanwei Gu; Jianglian She; Fahong Dai; Huanguo Jiang; Zhikun Zhan; Kunlong Li; Yonghong Liu; Xuefeng Zhou; Lan Tang. 2021. "LXR-Mediated Regulation of Marine-Derived Piericidins Aggravates High-Cholesterol Diet-Induced Cholesterol Metabolism Disorder in Mice." Journal of Medicinal Chemistry 64, no. 14: 9943-9959.
Four new chromene derivatives, pestalotiochromenoic acids A − D (1, 2, 4, and 5), and two new chromone derivatives, pestalotiochromones A and B (6 and 7), were obtained from the marine alga-derived fungus Pestalotiopsis neglecta SCSIO41403, as well as a reported derivate named piperochromenoic acid (3) with its configuration determined for the first time. Their structures were determined by detailed nuclear magnetic resonance (NMR) and mass spectroscopic analyses, while the absolute configurations were established by theoretical NMR and electronic circular dichroism (ECD) calculation, including Mo2(OAc)4-induced ECD experiments. Those chromene and chromone derivatives displayed weak cytotoxicity, but showed obvious liver X receptors (LXRs) modulatory activities, by in vitro tests on the expression of LXRα, LXRβ and their target gene ABCA1, as well as in silico docking analysis. Moreover, the high binding affinities between pestalotiochromone A (6) and LXRα, revealed by surface plasmon resonance (SPR) with the dissociation equilibrium constant (KD) value of 6.2 μM, demonstrated 6 could act as a new potential LXR agonist.
Zhi Liang; Tanwei Gu; Jianjiao Wang; Jianglian She; YuXiu Ye; Wenyu Cao; Xiaowei Luo; Jiao Xiao; Yonghong Liu; Lan Tang; Xuefeng Zhou. Chromene and chromone derivatives as liver X receptors modulators from a marine-derived Pestalotiopsis neglecta fungus. Bioorganic Chemistry 2021, 112, 104927 .
AMA StyleZhi Liang, Tanwei Gu, Jianjiao Wang, Jianglian She, YuXiu Ye, Wenyu Cao, Xiaowei Luo, Jiao Xiao, Yonghong Liu, Lan Tang, Xuefeng Zhou. Chromene and chromone derivatives as liver X receptors modulators from a marine-derived Pestalotiopsis neglecta fungus. Bioorganic Chemistry. 2021; 112 ():104927.
Chicago/Turabian StyleZhi Liang; Tanwei Gu; Jianjiao Wang; Jianglian She; YuXiu Ye; Wenyu Cao; Xiaowei Luo; Jiao Xiao; Yonghong Liu; Lan Tang; Xuefeng Zhou. 2021. "Chromene and chromone derivatives as liver X receptors modulators from a marine-derived Pestalotiopsis neglecta fungus." Bioorganic Chemistry 112, no. : 104927.
A new azaphthalide derivative, (S)-3-hydroxy-2,7-dimethylfuro [3,4-b]pyridin-5(7H)-one (1), and a new phthalide derivative, (S)-7-hydroxy-3-((S)-1-hydroxyethyl)isobenzofuran-1(3H)-one (2), were isolated from the coral-derived fungus Aspergillus sp. SCSIO41405, together with eight known compounds (3–10). Their structures, including absolute configurations, were determined by NMR and MS spectroscopic analyses, optical rotation, calculated electronic circular dichroism (ECD) and X-ray crystal data. The isolated compounds were examined for antibacterial and enzyme inhibition activities. Compounds 7 and 8 exhibited weak antibacterial activities, and 10 displayed moderate inhibition on pancreatic lipase with an IC50 value of 15.6 μg/mL.
Qingyun Peng; Jian Cai; Jieyi Long; Bin Yang; Xiuping Lin; Junfeng Wang; Jiao Xiao; Yonghong Liu; Xuefeng Zhou. New azaphthalide and phthalide derivatives from the marine coral-derived fungus Aspergillus sp. SCSIO41405. Phytochemistry Letters 2021, 43, 94 -97.
AMA StyleQingyun Peng, Jian Cai, Jieyi Long, Bin Yang, Xiuping Lin, Junfeng Wang, Jiao Xiao, Yonghong Liu, Xuefeng Zhou. New azaphthalide and phthalide derivatives from the marine coral-derived fungus Aspergillus sp. SCSIO41405. Phytochemistry Letters. 2021; 43 ():94-97.
Chicago/Turabian StyleQingyun Peng; Jian Cai; Jieyi Long; Bin Yang; Xiuping Lin; Junfeng Wang; Jiao Xiao; Yonghong Liu; Xuefeng Zhou. 2021. "New azaphthalide and phthalide derivatives from the marine coral-derived fungus Aspergillus sp. SCSIO41405." Phytochemistry Letters 43, no. : 94-97.
In devotion to investigating structurally novel and biologically active marine natural products, a dimer of a zinc complex, dizinchydroxyneoaspergillin (1), aspernones A–E (2–6), five cyclopentenone derivatives together with known polyketides (7–10), and neoaspergillic acid analogues (11–14) were isolated from the sponge-associated fungus Aspergillus ochraceopetaliformis SCSIO 41018. Their structures were elucidated on the basis of spectroscopic analysis, electronic circular dichroism (ECD) analysis, and X-ray diffraction. Dizinchydroxyneoaspergillin (1) displayed significant bactericide effects toward methicillin-resistant Staphyloccocus aureus, Staphyloccocus aureus, Enterococcus faecalis, Acinetobacter baumannii, and Klebsiella pneumonia with MIC values of 0.45–7.8 μg/mL and moderate in vitro cytotoxic activities against the K562, BEL-7402, and SGC-7901 cell lines with IC50 values of 12.88 ± 0.14, 15.83 ± 0.23, and 15.08 ± 0.62 μM, respectively. This is the first time to report the dimer of the zinc complex of hydroxyneoaspergillic acid conjunction at Zn–N-4 by a coordination bond. Additionally, compound 1 displayed significant antibacterial and cytotoxic activities, which would be a promising drug lead and could attract much attention from both chemists and pharmacists.
Cui Guo; Pei Wang; Xiaoyan Pang; Xiuping Lin; Shengrong Liao; Bin Yang; Xuefeng Zhou; Junfeng Wang; Yonghong Liu. Discovery of a Dimeric Zinc Complex and Five Cyclopentenone Derivatives from the Sponge-Associated Fungus Aspergillus ochraceopetaliformis. ACS Omega 2021, 6, 8942 -8949.
AMA StyleCui Guo, Pei Wang, Xiaoyan Pang, Xiuping Lin, Shengrong Liao, Bin Yang, Xuefeng Zhou, Junfeng Wang, Yonghong Liu. Discovery of a Dimeric Zinc Complex and Five Cyclopentenone Derivatives from the Sponge-Associated Fungus Aspergillus ochraceopetaliformis. ACS Omega. 2021; 6 (13):8942-8949.
Chicago/Turabian StyleCui Guo; Pei Wang; Xiaoyan Pang; Xiuping Lin; Shengrong Liao; Bin Yang; Xuefeng Zhou; Junfeng Wang; Yonghong Liu. 2021. "Discovery of a Dimeric Zinc Complex and Five Cyclopentenone Derivatives from the Sponge-Associated Fungus Aspergillus ochraceopetaliformis." ACS Omega 6, no. 13: 8942-8949.
A new polychiral bisabolane sesquiterpene, bisabolanoic acid A (1), was isolated from the mangrove-derived fungus Colletotrichum sp. SCSIO KcB3-2. Its planar structure was identified on the basis of spectroscopic data analysis (HRESIMS, 1D, and 2D NMR), and the absolute configurations of three chiral carbons were determined by experimental and calculated electronic circular dichroism (ECD) and optical rotatory dispersion (ORD), together with Mo2(OAc)4-induced ECD methods. Bisabolanoic acid A (1) showed moderate inhibitory activity against acetylcholinesterase (AChE) with IC50 value of 2.2 μM, and the in silico molecular docking was also performed. Graphical Abstract
Kun-Long Li; Yu Dai; Jiang-Lian She; Yan-Bo Zeng; Hao-Fu Dai; Shun-Ling Ou; Xue-Feng Zhou; Yong-Hong Liu. Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp. Journal of Asian Natural Products Research 2021, 1 -8.
AMA StyleKun-Long Li, Yu Dai, Jiang-Lian She, Yan-Bo Zeng, Hao-Fu Dai, Shun-Ling Ou, Xue-Feng Zhou, Yong-Hong Liu. Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp. Journal of Asian Natural Products Research. 2021; ():1-8.
Chicago/Turabian StyleKun-Long Li; Yu Dai; Jiang-Lian She; Yan-Bo Zeng; Hao-Fu Dai; Shun-Ling Ou; Xue-Feng Zhou; Yong-Hong Liu. 2021. "Bisabolanoic acid A, a new polychiral sesquiterpene with AChE inhibitory activity from a mangrove-derived fungus Colletotrichum sp." Journal of Asian Natural Products Research , no. : 1-8.
Four undescribed polyketide derivatives, named arthproliferins A–D (1–4), and one undescribed phenylspirodrimane derivative, named arthproliferin E (7), along with 11 known metabolites (5, 6, 8–16) were isolated from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201. Their structures were determined through spectroscopic methods, X-ray crystallography, and ECD analysis. Compounds 1 and 3–15 were evaluated for their cytotoxic, and antibacterial activities. Among them, compounds 1 and 15 displayed moderate inhibitory activity against methicillin-resistant Staphylococcus aureus ATCC 29213 with an MIC value of 78 and 39 µg/mL, respectively. Furthermore, compound 15 displayed strong cytotoxic activities against the tested cell line with IC50 values less than 39 nM.
Bin Yang; Jieyi Long; Xiaoyan Pang; Xiuping Lin; Shengrong Liao; Junfeng Wang; Xuefeng Zhou; Yunqiu Li; Yonghong Liu. Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201. The Journal of Antibiotics 2020, 74, 190 -198.
AMA StyleBin Yang, Jieyi Long, Xiaoyan Pang, Xiuping Lin, Shengrong Liao, Junfeng Wang, Xuefeng Zhou, Yunqiu Li, Yonghong Liu. Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201. The Journal of Antibiotics. 2020; 74 (3):190-198.
Chicago/Turabian StyleBin Yang; Jieyi Long; Xiaoyan Pang; Xiuping Lin; Shengrong Liao; Junfeng Wang; Xuefeng Zhou; Yunqiu Li; Yonghong Liu. 2020. "Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201." The Journal of Antibiotics 74, no. 3: 190-198.
A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4–6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo2 (OAc)4-induced ECD methods. The new compounds 1–3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 1.3–2.5 μM, and an in silico molecular docking study was also performed.
Yu Dai; Kunlong Li; Jianglian She; Yanbo Zeng; Hao Wang; Shengrong Liao; Xiuping Lin; Bin Yang; Junfeng Wang; Huaming Tao; Haofu Dai; Xuefeng Zhou; Yonghong Liu. Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401. Marine Drugs 2020, 18, 547 .
AMA StyleYu Dai, Kunlong Li, Jianglian She, Yanbo Zeng, Hao Wang, Shengrong Liao, Xiuping Lin, Bin Yang, Junfeng Wang, Huaming Tao, Haofu Dai, Xuefeng Zhou, Yonghong Liu. Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401. Marine Drugs. 2020; 18 (11):547.
Chicago/Turabian StyleYu Dai; Kunlong Li; Jianglian She; Yanbo Zeng; Hao Wang; Shengrong Liao; Xiuping Lin; Bin Yang; Junfeng Wang; Huaming Tao; Haofu Dai; Xuefeng Zhou; Yonghong Liu. 2020. "Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401." Marine Drugs 18, no. 11: 547.
Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (3-13). The structures of 1-13 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC50 values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml-1, respectively.
Weihao Chen; Chunmei Chen; Jieyi Long; Sujuan Lan; Xiuping Lin; Shengrong Liao; Bin Yang; Xuefeng Zhou; Junfeng Wang; Yonghong Liu. Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029. The Journal of Antibiotics 2020, 74, 156 -159.
AMA StyleWeihao Chen, Chunmei Chen, Jieyi Long, Sujuan Lan, Xiuping Lin, Shengrong Liao, Bin Yang, Xuefeng Zhou, Junfeng Wang, Yonghong Liu. Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029. The Journal of Antibiotics. 2020; 74 (2):156-159.
Chicago/Turabian StyleWeihao Chen; Chunmei Chen; Jieyi Long; Sujuan Lan; Xiuping Lin; Shengrong Liao; Bin Yang; Xuefeng Zhou; Junfeng Wang; Yonghong Liu. 2020. "Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029." The Journal of Antibiotics 74, no. 2: 156-159.
Background and Purpose Osteoclasts are unique cells to absorb bone, targeting osteoclast differentiation is a therapeutic strategy for osteolytic diseases. Marine natural products have already become important sources of new drugs. Naturally occurring nitrobenzoyl sesquiterpenoids (NSs), first identified from marine fungi in 1998, are bioactive compounds with a special structure, but their pharmacological functions are largely unknown. Here, we found a most potential NS from 6 marine fungus‐derived NSs and a NS derivative on osteoclastogenisis and elucidated the mechanisms. Experimental Approach Compounds were first tested by RANKL‐induced NF‐κ B luciferase activity and osteoclastic TRAP assay, followed by molecular docking to characterize the structure‐activity relationship. The effects and mechanisms of the most potential NS on RANKL‐induced osteoclastogenesis and bone resorption were further evaluated in vitro . Micro‐CT and histology analysis were used to assess the prevention of bone destruction by the NS in vivo . Key results NS4, with a nitrobenzoyl moiety connected to C‐14 and a hydroxyl group at C‐9, was the most active compound on NF‐κ B activity and osteoclastogenesis. Consequently, NS4 exhibited suppression of RANKL‐induced osteoclastogenesis and bone resorption from 0.5 μ M; it blocked RANKL‐induced Iκ Ba phosphorylation, NF‐κ B p65 and RelB nuclear translocation, NFATc1 activation, reduced DC‐STAMP but not c‐Fos expression during ostoclastogenesis in vitro . NS4 also ameliorated LPS‐induced osteolysis in vivo . Conclusions and implications These results highlighted NS4 as a novel inhibitor of osteoclast differentiation. This marine‐derived sesquiterpenoid is also a promising lead compound for the treatment of osteolytic diseases.
Yanhui Tan; Wende Deng; Yueyang Zhang; Minhong Ke; Binhua Zou; Xiaowei Luo; Jianbin Su; Yiyuan Wang; Jialan Xu; Kutty Selva Nandakumar; Yonghong Liu; Xuefeng Zhou; Xiaojuan Li. A marine fungus‐derived nitrobenzoyl sesquiterpenoid suppresses receptor activator of NF‐κB ligand‐induced osteoclastogenesis and inflammatory bone destruction. British Journal of Pharmacology 2020, 177, 4242 -4260.
AMA StyleYanhui Tan, Wende Deng, Yueyang Zhang, Minhong Ke, Binhua Zou, Xiaowei Luo, Jianbin Su, Yiyuan Wang, Jialan Xu, Kutty Selva Nandakumar, Yonghong Liu, Xuefeng Zhou, Xiaojuan Li. A marine fungus‐derived nitrobenzoyl sesquiterpenoid suppresses receptor activator of NF‐κB ligand‐induced osteoclastogenesis and inflammatory bone destruction. British Journal of Pharmacology. 2020; 177 (18):4242-4260.
Chicago/Turabian StyleYanhui Tan; Wende Deng; Yueyang Zhang; Minhong Ke; Binhua Zou; Xiaowei Luo; Jianbin Su; Yiyuan Wang; Jialan Xu; Kutty Selva Nandakumar; Yonghong Liu; Xuefeng Zhou; Xiaojuan Li. 2020. "A marine fungus‐derived nitrobenzoyl sesquiterpenoid suppresses receptor activator of NF‐κB ligand‐induced osteoclastogenesis and inflammatory bone destruction." British Journal of Pharmacology 177, no. 18: 4242-4260.
Three new carboxylic acid derivatives, pestallic acids F and G (1 and 2), pestalotiopyrone N (3), and a new diphenylketone derivative named neopestalone (5) were obtained from the liquid cultures of marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403, along with six known compounds (4, 6–10). The structures of those new compounds were elucidated mainly by analysis of their NMR and MS data. The isolated compounds were evaluated for their anti-Dengue virus and COX-2 inhibitory activities, and two diphenylketone derivatives (5 and 6) exhibited obvious COX-2 inhibitory activities, with the IC50 values being 5.8 and 3.4 μM, respectively.
Jianjiao Wang; Qingyun Peng; Xingang Yao; Yonghong Liu; Xuefeng Zhou. New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403. The Journal of Antibiotics 2020, 73, 585 -588.
AMA StyleJianjiao Wang, Qingyun Peng, Xingang Yao, Yonghong Liu, Xuefeng Zhou. New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403. The Journal of Antibiotics. 2020; 73 (8):585-588.
Chicago/Turabian StyleJianjiao Wang; Qingyun Peng; Xingang Yao; Yonghong Liu; Xuefeng Zhou. 2020. "New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403." The Journal of Antibiotics 73, no. 8: 585-588.
Seven unusual new ene-yne hydroquinones (1–3, 5–8), including three rare glycosylated derivatives named pestalotioquinosides A–C (6–8), were obtained from the marine-derived strain SCSIO41403 of the fungus Pestalotiopsis neglecta. Their structures including absolute configurations were elucidated by spectroscopic analysis and induced electronic circular dichroism experiments. In silico molecular docking and in vitro surface plasmon resonance studies showed that pestalotioquinoside C (8) could act as a liver X receptor alpha (LXRα) modulator. Further study showed that LXR target gene ABCA1 was significantly upregulated by 8, which revealed 8 as a potential LXRα agonist.
Jianjiao Wang; Zhi Liang; Kunlong Li; Bin Yang; Yonghong Liu; Wei Fang; Lan Tang; Xuefeng Zhou. Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha. Journal of Natural Products 2020, 83, 1258 -1264.
AMA StyleJianjiao Wang, Zhi Liang, Kunlong Li, Bin Yang, Yonghong Liu, Wei Fang, Lan Tang, Xuefeng Zhou. Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha. Journal of Natural Products. 2020; 83 (4):1258-1264.
Chicago/Turabian StyleJianjiao Wang; Zhi Liang; Kunlong Li; Bin Yang; Yonghong Liu; Wei Fang; Lan Tang; Xuefeng Zhou. 2020. "Ene-yne Hydroquinones from a Marine-derived Strain of the Fungus Pestalotiopsis neglecta with Effects on Liver X Receptor Alpha." Journal of Natural Products 83, no. 4: 1258-1264.
Twelve indole alkaloids, including α-cyclopiazonic acid (CPA) (1), nine 2-oxo indole CPA derivatives (2–10), and two open-ring indole CPA derivatives (11 and 12), were isolated from the fermentation broth of a deep-sea derived fungus Aspergillus sp. SCSIO 41024. Their structures and absolute configurations were elucidated mainly by using extensive NMR spectroscopic, mass spectrometric and single crystal X-ray diffraction analysis. To the best of our knowledge, the crystallographic data of 3 and 7 were firstly reported, and the absolute configuration of 3 was confirmed for the first time by the single crystal X-ray diffraction analysis. Most isolated compounds were tested for their antimicrobial, antitumor and radical scavenging activities. In addition, compounds 1, 2 and 11 showed moderate antioxidative activity against DPPH with IC50 values of 190.1, 31.9, 228.4 μg/mL, respectively.
Wei-Hao Chen; Kun-Long Li; Xiu-Ping Lin; Sheng-Rong Liao; Bin Yang; Xue-Feng Zhou; Junfeng Wang; Yong-Hong Liu. Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Natural Product Research 2020, 1 -5.
AMA StyleWei-Hao Chen, Kun-Long Li, Xiu-Ping Lin, Sheng-Rong Liao, Bin Yang, Xue-Feng Zhou, Junfeng Wang, Yong-Hong Liu. Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Natural Product Research. 2020; ():1-5.
Chicago/Turabian StyleWei-Hao Chen; Kun-Long Li; Xiu-Ping Lin; Sheng-Rong Liao; Bin Yang; Xue-Feng Zhou; Junfeng Wang; Yong-Hong Liu. 2020. "Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024." Natural Product Research , no. : 1-5.
Recent advances in the chemistry and biology of structurally diverse azaphilones from 2012 to 2019.
Chunmei Chen; Huaming Tao; Weihao Chen; Bin Yang; Xuefeng Zhou; Xiaowei Luo; Yonghong Liu. Recent advances in the chemistry and biology of azaphilones. RSC Advances 2020, 10, 10197 -10220.
AMA StyleChunmei Chen, Huaming Tao, Weihao Chen, Bin Yang, Xuefeng Zhou, Xiaowei Luo, Yonghong Liu. Recent advances in the chemistry and biology of azaphilones. RSC Advances. 2020; 10 (17):10197-10220.
Chicago/Turabian StyleChunmei Chen; Huaming Tao; Weihao Chen; Bin Yang; Xuefeng Zhou; Xiaowei Luo; Yonghong Liu. 2020. "Recent advances in the chemistry and biology of azaphilones." RSC Advances 10, no. 17: 10197-10220.
Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6-O-methyl-chaetoglobosin Q (1), were isolated from the coral-associated fungus Chaetomium globosum C2F17. Their structures were accomplished by extensive spectroscopic analysis combined with single-crystal X-ray crystallography and ECD calculations. Meanwhile, the structures and absolute configurations of the previously reported compounds 6, 12, and 13 were confirmed by single-crystal X-ray analysis for the first time. Chaetoglobosins E (6) and Fex (11) showed significant cytotoxicity against a panel of cancer cell lines, K562, A549, Huh7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4, with the IC50 values ranging from 1.4 μM to 9.2 μM.
Xiao-Wei Luo; Cheng-Hai Gao; Hu-Mu Lu; Jia-Min Wang; Zi-Qi Su; Hua-Ming Tao; Xue-Feng Zhou; Bin Yang; Yong-Hong Liu. HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17. Molecules 2020, 25, 1237 .
AMA StyleXiao-Wei Luo, Cheng-Hai Gao, Hu-Mu Lu, Jia-Min Wang, Zi-Qi Su, Hua-Ming Tao, Xue-Feng Zhou, Bin Yang, Yong-Hong Liu. HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17. Molecules. 2020; 25 (5):1237.
Chicago/Turabian StyleXiao-Wei Luo; Cheng-Hai Gao; Hu-Mu Lu; Jia-Min Wang; Zi-Qi Su; Hua-Ming Tao; Xue-Feng Zhou; Bin Yang; Yong-Hong Liu. 2020. "HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17." Molecules 25, no. 5: 1237.
Background: Long-term intake of a high-fat diet is a crucial factor contributing to obesity, which has become a global public health problem. Progressive obesity subsequently leads to hepatic injury, renal damage and intestinal atrophy. Transporters expressed in the liver, kidney and intestine play important roles in the deposition of nutrients and drugs, but researchers have not clearly determined whether/how the expression of transporters changes after long-term administration of a High-Fat Diet (HFD). This study aims to explore the effects of the long-term administration of a HFD on the expression of drug transporters in the liver, kidney and intestine in mice and to provide useful information for medical applications in the clinic. Methods: Male C57BL/6J mice were fed either a basal diet or HFD for 24 weeks, and oral glucose tolerance tests were performed after 3, 11 and 23 weeks. Serum was obtained to measure lipid metabolism, inflammatory mediators, renal function and hepatic function. Adipose tissues, kidney, pancreas and liver were collected for hematoxylin and eosin (H&E) staining after 4, 12 and 24 weeks. The mRNA and proteins expression of drug transporters in the liver, kidney and intestine were detected using real-time PCR and western blot, respectively. Results: Compared with the control group, long-term HFD administration significantly increased the adipose index. The serum lipid levels, including Total Cholesterol (TC), Triglyceride (TG), and Low-Density Lipoprotein Cholesterol (LDL-C), as well as the levels of the inflammatory cytokines Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) were significantly elevated in HFD-induced obese mice. H&E staining revealed pathological changes in the adipose cells, liver, kidney and pancreas from the obese group following the long-term administration of the HFD. The liver of the obese group presented increased mRNA expression of the efflux transporter Mrp2 and uptake transporter Oat2 at 24 weeks. The relative expression of Oat2 increased 4.08-fold and the protein expression of Oat2 was upregulated at 24 weeks in HFD-fed mice, while the mRNA expression of the uptake transporters Oct1, Oatp1b2 and Oatp1a4 decreased by 79%, 61% and 19%, respectively. The protein expression of Oct1 was significantly downregulated in obese mice at 12 weeks. The mRNA expression of the efflux transporter Mdr1a was significantly reduced in HFD-fed mice compared with the control group at 24 weeks. Western blot showed that the trend of protein level of Mdr1 was consistent with the mRNA expression. In the kidney, the level of the Oct2 mRNA increased 1.92- and 2.46-fold at 4 and 12 weeks in HFD-fed mice, respectively. The expression of the Oat1 and Oat3 mRNAs was markedly downregulated in the kidneys of mice with HFD-induced obesity at 4 weeks. The decrease of 72% and 21% in Mdr1a mRNA expression was observed in the obese model at 4 weeks and 12 weeks, respectively. Western blot showed that the protein levels of Mdr1 and Oat1 were consistent with the mRNA expression. The qPCR experiments showed a 2.87-fold increase in Bcrp mRNA expression at 24 weeks, and the expression of the Pept1 mRNA increased 2.84-fold in intestines of obese mice subjected to long-term administration of the HFD compared with control mice at 12 weeks. Western blot showed that the trend of protein levels of Mdr1 and Mrp2 were consistent with the mRNA expression. Conclusion: The expression of uptake and efflux transporters mRNAs and protein levels were altered in obese mice compared with control mice, providing scientific evidence for future medical applications in the clinic.
Xianyuan Lu; Yaqian Dong; Zhichao Jian; Qingyun Li; Linna Gong; Lan Tang; Xuefeng Zhou; Menghua Liu. Systematic Investigation of the Effects of Long-Term Administration of a High-Fat Diet on Drug Transporters in the Mouse Liver, Kidney and Intestine. Current Drug Metabolism 2019, 20, 742 -755.
AMA StyleXianyuan Lu, Yaqian Dong, Zhichao Jian, Qingyun Li, Linna Gong, Lan Tang, Xuefeng Zhou, Menghua Liu. Systematic Investigation of the Effects of Long-Term Administration of a High-Fat Diet on Drug Transporters in the Mouse Liver, Kidney and Intestine. Current Drug Metabolism. 2019; 20 (9):742-755.
Chicago/Turabian StyleXianyuan Lu; Yaqian Dong; Zhichao Jian; Qingyun Li; Linna Gong; Lan Tang; Xuefeng Zhou; Menghua Liu. 2019. "Systematic Investigation of the Effects of Long-Term Administration of a High-Fat Diet on Drug Transporters in the Mouse Liver, Kidney and Intestine." Current Drug Metabolism 20, no. 9: 742-755.
Paeonia suffruticosa is an ornamental, edible, and medicinal plant. The ethanolic extracts of P. suffruticosa bud and flower were examined for their antioxidant, anti-photoaging, and phytochemical properties prior to chemometric analysis. The results showed that the bud ethanolic extract (BEE) and the flower (the early flowering stage) ethanolic extract (FEE) had better antioxidant activities, and significantly increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and reduced the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the skin tissues. In total, 68 compounds, including 20 flavonoids, 15 phenolic derivatives, 12 terpenoids, 9 fatty acids, and 12 others were identified or tentatively identified by ultra-fast liquid chromatography quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF-MS). Gallic acid, 1,2,3,4,6-O-pentagalloyl glucose, paeoniflorin, and oxypaeoniflorin were predominant compounds in the extracts. Taken together, P. suffruticosa flowers are a candidate for functional material in food and health related industries, and their optimal time to harvest is before the early flowering stage.
Jingyu He; Yaqian Dong; Liu; Yiling Wan; Tanwei Gu; Xuefeng Zhou; He; Dong; Wan; Gu; Zhou; Xiaoyan Liu; Menghua Liu. Comparison of Chemical Compositions, Antioxidant, and Anti-Photoaging Activities of Paeonia suffruticosa Flowers at Different Flowering Stages. Antioxidants 2019, 8, 345 .
AMA StyleJingyu He, Yaqian Dong, Liu, Yiling Wan, Tanwei Gu, Xuefeng Zhou, He, Dong, Wan, Gu, Zhou, Xiaoyan Liu, Menghua Liu. Comparison of Chemical Compositions, Antioxidant, and Anti-Photoaging Activities of Paeonia suffruticosa Flowers at Different Flowering Stages. Antioxidants. 2019; 8 (9):345.
Chicago/Turabian StyleJingyu He; Yaqian Dong; Liu; Yiling Wan; Tanwei Gu; Xuefeng Zhou; He; Dong; Wan; Gu; Zhou; Xiaoyan Liu; Menghua Liu. 2019. "Comparison of Chemical Compositions, Antioxidant, and Anti-Photoaging Activities of Paeonia suffruticosa Flowers at Different Flowering Stages." Antioxidants 8, no. 9: 345.
Xiao-Wei Luo; Cheng-Hai Gao; Fang-Hai Han; Xian-Qiang Chen; Xiu-Ping Lin; Xue-Feng Zhou; Jun-Jian Wang; Yong-Hong Liu. A new naphthopyranone from the sponge-associated fungus Penicillium sp. XWS02F62. Magnetic Resonance in Chemistry 2019, 57, 982 -986.
AMA StyleXiao-Wei Luo, Cheng-Hai Gao, Fang-Hai Han, Xian-Qiang Chen, Xiu-Ping Lin, Xue-Feng Zhou, Jun-Jian Wang, Yong-Hong Liu. A new naphthopyranone from the sponge-associated fungus Penicillium sp. XWS02F62. Magnetic Resonance in Chemistry. 2019; 57 (11):982-986.
Chicago/Turabian StyleXiao-Wei Luo; Cheng-Hai Gao; Fang-Hai Han; Xian-Qiang Chen; Xiu-Ping Lin; Xue-Feng Zhou; Jun-Jian Wang; Yong-Hong Liu. 2019. "A new naphthopyranone from the sponge-associated fungus Penicillium sp. XWS02F62." Magnetic Resonance in Chemistry 57, no. 11: 982-986.
Two novel sorbicillinoid adducts containing bicyclo[2.2.2]octane and tetrahydrofuran moieties, named sorbicillfurans A and B (1 and 2), were isolated from the static culture of the marine-derived fungus Penicillium citrinum SCSIO41402.
Jianjiao Wang; Kunlong Li; Xiaowei Luo; Zhaoyuan Wu; Tanwei Gu; Shengrong Liao; Xiuping Lin; Bin Yang; Yonghong Liu; Wei Fang; Xuefeng Zhou. Sorbicillfurans A and B, two novel sorbicillinoid adducts from the fungus Penicillium citrinum SCSIO41402. Organic & Biomolecular Chemistry 2019, 17, 8721 -8725.
AMA StyleJianjiao Wang, Kunlong Li, Xiaowei Luo, Zhaoyuan Wu, Tanwei Gu, Shengrong Liao, Xiuping Lin, Bin Yang, Yonghong Liu, Wei Fang, Xuefeng Zhou. Sorbicillfurans A and B, two novel sorbicillinoid adducts from the fungus Penicillium citrinum SCSIO41402. Organic & Biomolecular Chemistry. 2019; 17 (38):8721-8725.
Chicago/Turabian StyleJianjiao Wang; Kunlong Li; Xiaowei Luo; Zhaoyuan Wu; Tanwei Gu; Shengrong Liao; Xiuping Lin; Bin Yang; Yonghong Liu; Wei Fang; Xuefeng Zhou. 2019. "Sorbicillfurans A and B, two novel sorbicillinoid adducts from the fungus Penicillium citrinum SCSIO41402." Organic & Biomolecular Chemistry 17, no. 38: 8721-8725.