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Josenilson Feitosa De Lima
Laboratory of Dermatology and Immunodeficiencies (LIM-56), Department of Dermatology, University of Sao Paulo Medical School, Sao Paulo-SP 01246-903, Brazil.

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Review
Published: 05 June 2019 in Toxins
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Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease.

ACS Style

Fabio Seiti Yamada Yoshikawa; Josenilson Feitosa De Lima; Maria Notomi Sato; Yasmin Álefe Leuzzi Ramos; Valeria Aoki; Raquel Leao Orfali. Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis. Toxins 2019, 11, 321 .

AMA Style

Fabio Seiti Yamada Yoshikawa, Josenilson Feitosa De Lima, Maria Notomi Sato, Yasmin Álefe Leuzzi Ramos, Valeria Aoki, Raquel Leao Orfali. Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis. Toxins. 2019; 11 (6):321.

Chicago/Turabian Style

Fabio Seiti Yamada Yoshikawa; Josenilson Feitosa De Lima; Maria Notomi Sato; Yasmin Álefe Leuzzi Ramos; Valeria Aoki; Raquel Leao Orfali. 2019. "Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis." Toxins 11, no. 6: 321.