Bone is a hard-vascularized tissue, which renews itself continuously to adapt to the mechanical and metabolic demands of the body. The craniofacial area is prone to trauma and pathologies that often result in large bone damage, these leading to both aesthetic and functional complications for patients. The “gold standard” for treating these large defects is autologous bone grafting, which has some drawbacks including the requirement for a second surgical site with quantity of bone limitations, pain and other surgical complications. Indeed, tissue engineering combining a biomaterial with the appropriate cells and molecules of interest would allow a new therapeutic approach to treat large bone defects while avoiding complications associated with a second surgical site. This review first outlines the current knowledge of bone remodeling and the different signaling pathways involved seeking to improve our understanding of the roles of each to be able to stimulate or inhibit them. Secondly, it highlights the interesting characteristics of one growth factor in particular, FGF-2, and its role in bone homeostasis, before then analyzing its potential usefulness in craniofacial bone tissue engineering because of its proliferative, pro-angiogenic and pro-osteogenic effects depending on its spatial-temporal use, dose and mode of administration.

La santé bucco-dentaire participe au maintien d’un bon état général de l’organisme. Certaines populations, dont les personnes détenues, ont des besoins importants mais, simultanément, un accès limité aux soins dentaires. Télédent est un outil complémentaire de téléexpertise bucco-dentaire qui facilite le dépistage et la prévention des troubles oraux. À partir d’une caméra intra-buccale qui enregistre des images qui sont analysées par l’équipe du service de médecine bucco-dentaire de l’Hôpital Henri Mondor, l’Unité sanitaire du centre pénitentiaire de Fresnes dispose d’une expertise dentaire détaillée. Télédent permet ainsi une coopération entre les services qui améliore le dépistage et la prise en charge de soins bucco-dentaires, tout en diminuant les coûts et en favorisant la sécurité des patients détenus.