The use of hybrid manufacturing to produce bimodal scaffolds has represented a great advancement in tissue engineering. These scaffolds provide a favorable environment in which cells can adhere and produce new tissue. However, there are several areas of opportunity to manufacture structures that provide enough strength and rigidity, while also improving chemical integrity. As an advancement in the manufacturing process of scaffolds, a cooling system was introduced in a fused deposition modeling (FDM) machine to vary the temperature on the printing bed. Two groups of polylactic acid (PLA) scaffolds were then printed at two different bed temperatures. The rate of degradation was evaluated during eight weeks in Hank’s Balanced Salt Solution (HBSS) in a controlled environment (37 °C–120 rpm) to assess crystallinity. Results showed the influence of the cooling system on the degradation rate of printed scaffolds after the immersion period. This phenomenon was attributable to the mechanism associated with alkaline hydrolysis, where a higher degree of crystallinity obtained in one group induced greater rates of mass loss. The overall crystallinity was observed, through differential scanning calorimetry (DSC), thermo gravimetric analysis (TGA), and Fourier transformed infrared spectroscopy (FTIR) analysis, to increase with time because of the erosion of some amorphous parts after immersion.

Currently, electrospinning membranes for vascular graft applications has been limited, due to random fiber alignment, to use in mandrel-spun, straight tubular shapes. However, straight, circular tubes with constant diameters are rare in the body. This study presents a method to fabricate curved, non-circular, and bifurcated vascular grafts based on electrospinning. In order to create a system capable of electrospinning membranes to meet specific patient needs, this study focused on characterizing the influence of fiber source, electrical field collector position (inside vs. outside the mandrel), and the motion scheme of the mandrel (rotation vs. rotation and tilting) on the vascular graft membrane morphology and mechanical properties. Given the extensive use of poly(ε-caprolactone) (PCL) in tubular vascular graft membranes, the same material was used here to facilitate a comparison. Our results showed that the best morphology was obtained using orthogonal sources and collector positioning, and a well-timed rotation and tilting motion scheme. In terms of mechanical properties, our bifurcated vascular graft membranes showed burst pressure comparable to that of tubular vascular graft membranes previously reported, with values up to 5126 mmHg. However, the suture retention strength shown by the bifurcated vascular graft membranes was less than desired, not clinically viable values. Process improvements are being contemplated to introduce these devices into the clinical range.

Electrospinning, Forcespinning^®, and melt electrowriting are becoming increasingly important fiber-based fabrication technologies for tissue engineering and drug delivery applications. Despite their scientific and industrial relevance, their patent landscape has not been systematically examined, which limits the understanding of technological dynamics and translational applications. This study addresses this gap through a patentometric analysis conducted within a Competitive Technology Intelligence framework. A total of 3557 active and granted Extended Patent Families from 2020 to 2024 were analyzed to identify temporal patterns, geographic distribution, key innovators, industrial sectors, and primary application areas. The results showed that the overall patent activity increased until 2022 before experiencing a slight decline. China dominates the landscape, accounting for approximately 62% of applications filed, largely driven by academic institutions such as Shanghai University. Leading industries include special-purpose machinery, medical and dental technology, and textiles. According to International Patent Classification codes, filament formation (D01D5/00) is prevalent, while electrospinning—specifically IPC D04H1/728—represents the most active and influential of the three technologies. These findings exhibit the technological dynamics shaping fiber-based fabrication platforms and underscore their growing relevance in pharmaceutical innovation. The identified trends position these technologies as foundational for next-generation biomaterial design, offering valuable insights for researchers, industry stakeholders, and policymakers.