In this confirmatory study, we tested if a calculation that included the non-uniformity of dose deposition through a voxel-based dosimetric variable Ψ was able to improve the dose–response agreement with respect to the mean absorbed dose D. We performed dosimetry with ^99mTc-MAA SPECT/CT and ⁹⁰Y-PET/CT in 86 patients treated 8 instead of 4 days after the reference date with 2.8 times more ⁹⁰Y glass microspheres/GBq than in our previous study. The lesion-by-lesion response was assessed with the mRECIST method and with an experimental densitometric criterion. A total of 106 lesions were studied. Considering Ψ as a prognostic response marker, having no Ψ provided a significantly higher AUC than D. The correlation, t-test, and AUC values were statistically significant only with the densitometric method and only with post-therapy dosimetry. In comparison with our previous study, the dose–response correlation and AUC values were poorer (maximum r = 0.43, R² = 0.14, maximal AUC = 0.71), and the efficacy at a high dose did not reach 100%. The expected advantages of voxel dosimetry were nullified by the correlation between any Ψ and D due to the limited image spatial resolution. The lower AUC and efficacy may be explained by the mega-clustering effect triggered by the higher number of microspheres/GBq injected on day 8.

Aim of this work is evaluate the performance of LiF detectors, TLD-100H, used for both environmental and radiodiagnostic dosimetry. General-Order kinetics (GOK) expressions were applied to experimental glow curves of TLDs 100H (LiF. Mg, P, Cu), that were irradiated with an X-ray tube at 140 kVp and reading with a Riso TL/OSL-DA-10 system. New tests were introduced such as the Recuperation test, for evaluate the residual luminescent after each measurement cycle, the Recycling test, aimed to evaluate any systematic errors in the calibration curve and, at last, the Recovery test, with the purpose of evaluate the accuracy of the measured dose from each single dosimeter. The results obtained show an accuracy on the various measured doses ranging from 1.20% to 2.56%.

Objective: To give an updated overview on clinical aspects and survival effects of lutetium-177–prostate-specific membrane antigen (PSMA) (¹⁷⁷Lu-PSMA) radioligand therapy (RLT), a novel treatment option for patients with metastatic castration-resistant prostate cancer (mCRPC). Methods: PubMed/MEDLINE database was searched for relevant articles published up to March 2021. The search was restricted to English-language articles. Results: Current evidence from the literature consistently demonstrated the efficacy, safety, and survival benefit of ¹⁷⁷Lu-PSMA RLT in mCRPC. However, current data rely predominantly on retrospective analyses, showing heterogeneity of patient population and treatment protocols. More recently, results from the first randomized phase II study (TheraP) demonstrated that ¹⁷⁷Lu-PMSA therapy significantly improved prostate-specific antigen response rate (66% vs 37%) and had fewer grade 3/4 adverse events when compared to cabazitaxel in patients with docetaxel-pretreated, progressive mCRPC. This review is intended to provide an updated overview of treatment protocols and responses, toxicity profile, and survival effects of ¹⁷⁷Lu-PSMA RLT. Conclusions: ¹⁷⁷Lu-PSMA RLT has emerged as a promising targeted treatment in mCRPC. It is currently applied in compassionate use programs and following exhaustion of approved therapies. Crucial for establishing this treatment in routine clinical management will be the results of the phase III VISION trial, which may confirm the encouraging patient outcomes reported to date.

The aim of this work is to propose a new methodological approach, using TLD400, to perform point dosimetry in medical physics applications. It investigates the possibility of using simultaneously the luminescence signals by optical stimulation with blue diode (OSL) and residual signals by thermal stimulation (ReTL), from TLD400, CaF₂:Mn, for dosimetric purposes. Artificial irradiation was performed with ⁹⁰Sr-⁹⁰Y, calibrated beta sources delivering 6 Gy/min and integrated in the TL-DA-15 automated RisØ readers equipped with EMI 9235QA photomultipliers. In particular, for OSL measurements, to check the correct experimental conditions, the effect of the stimulation temperature during optical stimulation and the effect of the optical stimulation time were studied. For calibration curves from OSL and ReTL signals, a double Single Aliquot Regeneration (SAR) procedure was used, in which the "sensitivity-corrected" natural stimulated luminescence signal is compared with equivalent sensitivity-corrected signals regenerated by laboratory irradiation of the same aliquot. The double OSL and ReTL combined measurements allow to have a good accuracy coverage (≤2%) in the whole dose range between 0 and 10 Gy.