Clinical studies investigating the benefits of beta-lactam therapeutic drug monitoring (TDM) among critically ill patients are hindered by small patient groups, variability between studies, patient heterogeneity, and inadequate use of TDM. Accordingly, definitive conclusions regarding the efficacy of TDM remain elusive. To address these challenges, we propose an innovative approach that leverages data-driven methods to unveil the concealed connections between therapy effectiveness and patient data, collected through a randomized controlled trial (DRKS00011159; 10th October 2016). Our findings reveal that machine learning algorithms can successfully identify informative features that distinguish between healthy and sick states. These hold promise as potential markers for disease classification and severity stratification, as well as offering a continuous and data-driven "multidimensional" Sequential Organ Failure Assessment (SOFA) score. The positive impact of TDM on patient recovery rates is demonstrated by unraveling the intricate connections between therapy effectiveness and clinically relevant data via machine learning.

Predictive maintenance is considered a proactive approach that capitalizes on advanced sensing technologies and data analytics to anticipate potential equipment malfunctions, enabling cost savings and improved operational efficiency. For journal bearings, predictive maintenance assumes critical significance due to the inherent complexity and vital role of these components in mechanical systems. The primary objective of this study is to develop a data-driven methodology for indirectly determining the wear condition by leveraging experimentally collected vibration data. To accomplish this goal, a novel experimental procedure was devised to expedite wear formation on journal bearings. Seventeen bearings were tested and the collected sensor data were employed to evaluate the predictive capabilities of various sensors and mounting configurations. The effects of different downsampling methods and sampling rates on the sensor data were also explored within the framework of feature engineering. The downsampled sensor data were further processed using convolutional autoencoders (CAEs) to extract a latent state vector, which was found to exhibit a strong correlation with the wear state of the bearing. Remarkably, the CAE, trained on unlabeled measurements, demonstrated an impressive performance in wear estimation, achieving an average Pearson coefficient of 91% in four different experimental configurations. In essence, the proposed methodology facilitated an accurate estimation of the wear of the journal bearings, even when working with a limited amount of labeled data.