A one-step synthesis of phloretin derivatives 2–11 from phloretin in good to excellent yields is reported. Their structures were characterized by ¹H-NMR, ¹³C-NMR and MS, and the structures of 8 and 11 were determined by X-ray diffraction analysis. A mechanism for the formation of 9–11 is proposed. Compared with the anticancer drug docetaxel, phloretin, phloretin derivatives and phlorizin exhibited moderate cytotoxicity toward the MDA-MB-231, SPC-A1, A549, MCF-7 and EC109 cell lines. Among all of the tested compounds, 7 exhibited the strongest cytotoxicity toward the five cell lines and was more active than docetaxel in MDA-MB-231 cells. Our findings suggest that these derivatives hold great promise for further development as anticancer agents.

Objective: To understand the profession, the purpose of community internship, the mastery of general medicine theory, and the factors affecting community internship among students receiving free medical training (hereinafter referred to as the free medical students). Methods: Taking medical students of a particular school in 2012, 2013, and 2014 as the survey subjects, electronic questionnaires were issued using the “Star Questionnaire” platform. Results: A total of 225 electronic questionnaires were collected. Univariate and linear regression analyses were conducted on the basic understanding of the profession and community internship. Pearson correlation coefficient analysis was also conducted to analyze the factors affecting community internships of free medical students. In terms of mastery of general medicine theory, 35.56% of the students mastered medical history collection and case writing skills. The understanding and mastery of clinical diagnosis and treatment methods, basic principles of general medicine, service models, and family-based management are relatively low, with percentages of 14.67%, 13.78%, and 12.89%, respectively. Conclusion: In the training of general medical students, it is important to provide strong guidance for their career planning. This will help them gain a better understanding and appreciation of the field of general medicine. Additionally, increasing their awareness of the role of general practitioners in the community is crucial. The focus of their training should be on developing clinical diagnosis and treatment skills, as well as fostering a patient-centered approach to healthcare.