Giuseppe Legname earned his Doctor of Philosophy at the University of Warwick, UK. After a long spell in industry in the field of immunotherapy, he moved to the National Institute for Medical Research (NIMR), Medical Research Council in London, UK, as a Research Associate. In 1999, Giuseppe Legname became an Assistant Adjunct Professor and later an Associate Adjunct Professor at the Institute for Neurodegenerative Diseases (IND), University of California, San Francisco, USA. In 2006, he joined the faculty of SISSA in Trieste as an Associate Professor at the Department of Neuroscience. Currently, Giuseppe Legname is a Full Professor of Biochemistry at SISSA (Scuola Internazionale Superiore di Studi Avanzati, Trieste, Italy), specializing in neuroscience and neurodegenerative diseases, particularly prion biology. His work covers molecular and cellular biochemistry, focusing on the structural mechanisms of protein misfolding and its implications in neurodegeneration. Over the course of his career, he has extensively contributed to understanding the structural traits of prion proteins, their functional interactions, and therapeutic strategies for related diseases. He has over 20 years of teaching and mentoring experience, including the supervision of Ph.D. students, and has been involved in numerous international collaborations and scientific organizations.