As a promising candidate for expanding the capacity of drug loading in silica nanoplatforms, hollow mesoporous silica nanoparticles (HMSNs) are gaining increasing attention. In this study, porous nanosilica (PNS) and HMSNs were prepared by the sol-gel method and template assisted method, then further used for Rhodamine (RhB) loading. To characterize the as-synthesized nanocarriers, a number of techniques, including X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption-desorption isotherms, dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR) were employed. The size of HMSN nanoparticles in aqueous solution averaged 134.0 ± 0.3 nm, which could be adjusted by minor changes during synthesis, whereas that of PNS nanoparticles was 63.4 ± 0.6 nm. In addition, the encapsulation of RhB into HMSN nanoparticles to form RhB-loaded nanocarriers (RhB/HMSN) was successful, achieving high loading efficiency (51.67% ± 0.11%). This was significantly higher than that of RhB-loaded PNS (RhB/PNS) (12.24% ± 0.24%). Similarly, RhB/HMSN also possessed a higher RhB loading content (10.44% ± 0.02%) compared to RhB/PNS (2.90% ± 0.05%). From those results, it is suggested that prepared HMSN nanocarriers may act as high-capacity carriers in drug delivery applications.

In this work, AgNPs/PVA/Cellulose was used as a substrate material for surface Raman scattering enhancement. Silver nanoparticles (AgNPs) was synthesized by Lee and Meisel’s method with the average particles size of 15.4 nm. Then, this silver colloid was made a homogenous coating on polyvinyl alcohol and cellulose film and structural characteristics of this material were determined using Scanning Electron Microscopy (SEM). The findings demonstrated that the Raman shifts of the pesticide will be identified by the SERS method at 1660 cm⁻¹, 2234 cm⁻¹ (strong intensity), and at 3077 cm⁻¹, 1033 cm⁻¹, 1457 cm⁻¹ (medium intensity) when using the excited laser with wavelength of 532 nm. Under excited laser, the limit of chlorfenapyr detection is 1 ppm (mg l⁻¹), allowing determination of chlorfenapyr residue in food. Potential applications identified food samples containing chlorfenapyr residue for rapid detection, low cost, non-destructive nature and minimal sample preparation.

Currently, the use of nanoparticles as “carriers” to deliver drugs to the correct location has attracted the attention of scientists. Nano silica (SNs) is widely studied as material for biomedical applications. In this study, SNs particles were synthesized using the Stober method. The study investigated two factors affecting the morphology and particle size: reaction time and NH3 solution addition rate. Determining the characteristic properties of the material, methods used include transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and the N2 adsorption-desorption. SNs particles are spherical and highly homogeneous, with a 105.06 ± 0.74 nm size. The efficiency and loading capacity of Dox of SNs particles were 17.70 ± 0.52 % and 4.11 ± 0.11 %, respectively. The SNs/Dox drug carrier system has good potential for controlled drug release.

Hiện nay, việc sử dụng các hạt nano làm “vật tải” để đưa thuốc đến đúng vị trí đã thu hút sự chú ý của các nhà khoa học. Đặc biệt, kích thước hạt là một trong những yếu tố quan trọng ảnh hưởng đến khả năng mang và phóng thích thuốc của các hạt nano. Trong nghiên cứu này, các hạt nano silica đã được tổng hợp bằng phương pháp Stober kết hợp sử dụng thiết kế thí nghiệm Box–Behnken designs. Kết quả hạt nano silica tạo thành có kích thước phù hợp với giá trị dự đoán, cho thấy độ tin cậy của mô hình được đề xuất. Nghiên cứu góp phần tạo nên vật liệu hứa hẹn là vật liệu tiềm năng cho các hệ dẫn truyền thuốc.