Rodrigo Muñoz-Cofré

Prof. Rodrigo Muñoz-Cofré

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Research Focus & Metrics

Academic Career Length

10Years (2017-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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5 April 2022 in Medicina
Verified
Journal Article
Open access
PDF file
MVMaria Fernanda Del valle
Maria Fernanda Del valle
JVJorge Valenzuela
Jorge Valenzuela
GMGabriel Nasri Marzuca-Nassr
Gabriel Nasri Marzuca-Nassr
CCConsuelo Cabrera-Inostroza
Consuelo Cabrera-Inostroza
MSMariano Del Sol
Mariano Del Sol
RMRodrigo Muñoz-Cofré
Rodrigo Muñoz-Cofré
Background and Objectives: Patients who survive severe COVID-19 require significant pulmonary rehabilitation. Heart rate (HR) has been used as a safety variable in the evaluation of the results of interventions in patients undergoing pulmonary rehabilitation. The aim of this research was to analyse HR during a pulmonary rehabilitation program in post-severe COVID-19 patients who survived mechanical ventilation (MV). The study includes the initial and final evaluations and aerobic training sessions. Materials and Methods: Twenty patients (58 ± 13 years, 11 men) were trained for 8 weeks. A 6-minute walk test (6 MWT) was performed and, subsequently, a supervised and individualised training plan was created. Resting heart rate (RHR), heart rate recovery (HRR), heart rate at minute 6 (HR6 min) and the product of HR6 min and systolic blood pressure (HR6 minxSBP) were measured at 6 MWT. In addition, HR was measured at each training session. Results: After 8 weeks of pulmonary rehabilitation, patients decreased their RHR from 81.95 ± 9.36 to 73.60 ± 9.82 beats/min (p < 0.001) and significantly increased their HRR from 12.45 ± 10.22 to 20.55 ± 7.33 beats/min (p = 0.005). HR6 min presented a significant relationship with walking speed and walked distance after the pulmonary rehabilitation period (r = 0.555, p = 0.011 and r = 0.613, p = 0.011, respectively). HR6 minxSBP presented a significant relationship with walking speed and walked distance after training (r = 0.538, p = 0.014 and r = 0.568, p = 0.008, respectively). In the pulmonary rehabilitation sessions, a significant decrease in HR was observed at minutes 1, 6 and 15 (p < 0.05) between sessions 1 and 6 and at minute 1 between sessions 1 and 12. Conclusions: Eight weeks of individualised and supervised pulmonary rehabilitation were effective in improving RHR and HRR in COVID-19 patients surviving MV. HR is an easily accessible indicator that could help to monitor the evaluation and development of a pulmonary rehabilitation program in COVID-19 patients who survived MV.

RÁRoberto Álvarez
Roberto Álvarez
MVMaria Fernanda Del valle
Maria Fernanda Del valle
PCPablo Cordero
Pablo Cordero
MSMariano Del Sol
Mariano Del Sol
PLPablo A Lizana
Pablo A Lizana
RMRodrigo Muñoz-Cofré
Rodrigo Muñoz-Cofré
COVID-19 has caused a certain proportion of patients to be hospitalized in intensive care units (ICU) and may cause musculoskeletal and neurological deficits following intubation and mechanical ventilation. The aim of this study was to quantify and describe the presence of shoulder pain in patients released from hospitals after suffering COVID-19. Patients with positive Apley tests were sent to a physiatrist for a clinical evaluation, ultrasound and electromyography (EMG). This evaluation was completed with a pain scale, joint range and shoulder muscle strength evaluations. Of the one-hundred-sixteen patients, seventy eight entered the respiratory rehabilitation program. Twenty patients were sent to the multidisciplinary shoulder team for positive Apley scratch tests. Of these twenty patients, one had only an EMG, ten had only ultrasounds, seven had an EMG and ultrasound and two did not need complementary tests. The twenty patients were sent to the physical therapist, with all presenting pain and diminished joint range and muscle strength in the affected shoulder. In this context, shoulder pain could be associated with the prone position in the ICU. We suggest time control and position change for patients on mechanical ventilation in a prone position with COVID-19.

15 December 2021 in Respirology
Verified
Journal Article
Open access
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MVMaría Fernanda del Valle
María Fernanda del Valle
JVJorge Valenzuela
Jorge Valenzuela
LGLoretto Godoy
Loretto Godoy
MSMariano del Sol
Mariano del Sol
PLPablo A. Lizana
Pablo A. Lizana
RMRodrigo Muñoz-Cofré
Rodrigo Muñoz-Cofré
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1 January 2024 in Therapeutic Advances in Respiratory Disease
Verified
Journal Article
Open access
MVMaría Fernanda del Valle
María Fernanda del Valle
JVJorge Valenzuela
Jorge Valenzuela
CBClaudio Bascour-Sandoval
Claudio Bascour-Sandoval
GMGabriel Nasri Marzuca-Nassr
Gabriel Nasri Marzuca-Nassr
MSMariano del Sol
Mariano del Sol
RMRodrigo Muñoz-Cofré
Rodrigo Muñoz-Cofré
Background: Severe coronavirus 2019 disease (COVID-19) causes acute hypoxemic respiratory failure requiring invasive mechanical ventilation (IMV). Once these symptoms are resolved, patients can present systemic deterioration. Objective: The two objectives of this study were as follows: to describe the results of a pulmonary rehabilitation program (PRP), which is divided into three groups with different numbers of sessions (12, 24, and 36), and to associate the variables of pulmonary function, exercise performance, and functionality with the number of sessions and functional improvement. Design: Prospective, observational study. Methods: PRP consisted of aerobic + strength + flexibility exercises under the supervision and individualized into 12, 24, or 36 sessions (12s, 24s, and 36s), depending on the evolution of each patient. At the beginning of the study and immediately after the intervention, forced vital capacity (FVC), maximal inspiratory pressure, 6-minute walk test (6MWT), sit-to-stand test (STS), maximal handgrip strength (HGS), Fatigue Assessment Scale, Post-COVID-19 Functional Status (PCFS), and health-related quality of life (HRQoL) were measured. Results: The proposed PRP demonstrated a positive effect on pulmonary function, exercise performance, and HRQoL, regardless of the number of sessions. A higher score on the PCFS and more days on IMV were associated with the increased likelihood of needing more sessions, whereas more meters on the 6MWT in the initial evaluation was associated with a reduced likelihood of needing more sessions. Finally, more repetitions on the STS and less distance covered on the initial 6MWT were associated with a greater improvement in exercise performance evaluated with the 6MWT. Conclusion: Supervised and individualized PRP for patients with severe post-COVID-19 improves pulmonary function, exercise performance, functionality, and quality of life. Functionality, distance covered on the 6MWT, and the days on IMV are central to the scheduling of the number of sessions for these patients.

7 March 2023 in Annals of Medicine
Verified
Journal Article
Open access
MVMaría Fernanda del Valle
María Fernanda del Valle
JVJorge Valenzuela
Jorge Valenzuela
GMGabriel Nasri Marzuca-Nassr
Gabriel Nasri Marzuca-Nassr
LGLoretto Godoy
Loretto Godoy
MSMariano Del Sol
Mariano Del Sol
RMRodrigo Muñoz-Cofré
Rodrigo Muñoz-Cofré
Introduction Patients who suffered severe COVID-19 need pulmonary rehabilitation. Training may be prescribed objectively based on the maximum speed in the six-minute walk test. The objective of this study was to determine the effects of a personalized pulmonary rehabilitation program based on the six-minute walk test speed for post-COVID-19 patients. Methods Observational quasi-experimental study. The pulmonary rehabilitation program consisted of 8 weeks of training, twice a week for 60 minutes per session of supervised exercise. Additionally, the patients carried out home respiratory training. Patients were evaluated by exercise test, spirometry and the Fatigue Assessment Scale before and after the eight-week pulmonary rehabilitation program. Results After the pulmonary rehabilitation program, forced vital capacity increased from 2.47 +/- 0.60 to 3.06 +/- 0.77 L (p < .001) and the six-minute walk test result increased from 363.50 +/- 88.87 to 480.9 +/- 59.25 m (p < .001). In fatigue perception, a significant decrease was observed, from 24.92 +/- 7.01 to 19.10 +/- 7.07 points (p < .01). Isotime evaluation of the Incremental Test and the Continuous Test showed a significant reduction in heart rate, dyspnoea and fatigue. Conclusion The eight-week personalized pulmonary rehabilitation program prescribed on the basis of the six-minute walk test speed improved respiratory function, fatigue perception and the six-minute walk test result in post-COVID-19 patients. KEY MESSAGES COVID-19 is a multisystem disease with common complications affecting the respiratory, cardiac and musculoskeletal systems. The 6MWT speed-based training plan allowed for increased speed and incline during the eight-week RP program. Aerobic, strength and flexibility training reduced HR, dyspnoea and fatigue in severe post-COVID-19 patients.

1 August 2019 in Archivos Argentinos de Pediatria
Verified
Journal Article
Closed access
RMRodrigo Muñoz-Cofré
Rodrigo Muñoz-Cofré
MSMariano del Sol
Mariano del Sol
PGPaul Medina Gonzalez
Paul Medina Gonzalez
JIJaviera Escobar Inostroza
Javiera Escobar Inostroza
PLPablo A. Lizana
Pablo A. Lizana
MCMaximo Escobar Cabello
Maximo Escobar Cabello
Introduction. Obesity is associated with a rapid decrease in ventilatory function. The most common way of assessing nutritional status and measuring abdominal fat and hips are the body mass index (BMI) and the waist-hip ratio (WHR). There is scarce evidence suggesting their relation to functional residual capacity (FRC). Our objective was to determine the relation among BMI, WHR, and FRC in obese children in the city of Talca, Chile. Population and methods. Male and female children were recruited (6-12 years). Weight, height, BMI, WHR, and pulmonary function were assessed; the latter with body plethysmography. Depending on data distribution, Student's t test or the Mann-Whitney U test were used for independent samples, while Pearson's or Spearman's r test was used to establish the correlation between WHR and FRC. Results. Children were divided into normal weight (n = 18) and obese (n = 18). A significant reduction in FRC (p = 0.025) was reported in obese children, while a reverse association was observed between WHR and FRC, which was moderate in normal weight children (s = -0.489; p = 0.03) and high in obese children (r = -0.681; p = 0.001). Conclusions. Obese children showed a lower FRC compared to normal weight children, which, in turn, was associated with WHR. These results are indicative of the systemic effects caused by obesity on children's ventilatory function and the need to use body fat distribution indicators at an early age.