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Changjun Gao
Guangdong Academy of Forestry, Guangzhou 510520, China

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Research article
Published: 05 December 2020 in BioMed Research International
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Aim of the Study. This study is aimed at exploring the effects and pharmacological mechanisms of the extracts from the Heritiera littoralis fruit (EFH) on dextran sulfate sodium- (DSS-) induced ulcerative colitis (UC) in mice. Materials and Methods. The chemical compositions of EFH were identified using LC-ESI-MS. The mice with 3% DSS-induced UC were administered EFH (200, 400, and 800 mg/kg), sulfasalazine (SASP, 200 mg/kg), and azathioprine (AZA, 13 mg/kg) for 10 days via daily gavage. The colonic inflammation was evaluated by the disease activity index (DAI), colonic length, histological scores, and levels of inflammatory mediators. The gut microbiota was characterized by 16S rRNA gene sequencing and analysis. Results. LC-ESI-MS analysis showed that EFH was rich in alkaloids and flavones. The results indicated that EFH significantly improved the DAI score, relieved colon shortening, and repaired pathological colonic variations in colitis. In addition, proteins in the NF-κB pathway were significantly inhibited by EFH. Furthermore, EFH recovered the diversity and balance of the gut microbiota. Conclusions. EFH has protective effects against DSS-induced colitis by keeping the balance of the gut microbiota and suppressing the NF-κB pathway.

ACS Style

Guosheng Lin; Minyao Li; Nan Xu; Xiaoli Wu; Jingjing Liu; Yulin Wu; Qian Zhang; Jian Cai; Changjun Gao; Ziren Su. Anti-Inflammatory Effects of Heritiera littoralis Fruits on Dextran Sulfate Sodium- (DSS-) Induced Ulcerative Colitis in Mice by Regulating Gut Microbiota and Suppressing NF-κB Pathway. BioMed Research International 2020, 2020, 1 -20.

AMA Style

Guosheng Lin, Minyao Li, Nan Xu, Xiaoli Wu, Jingjing Liu, Yulin Wu, Qian Zhang, Jian Cai, Changjun Gao, Ziren Su. Anti-Inflammatory Effects of Heritiera littoralis Fruits on Dextran Sulfate Sodium- (DSS-) Induced Ulcerative Colitis in Mice by Regulating Gut Microbiota and Suppressing NF-κB Pathway. BioMed Research International. 2020; 2020 ():1-20.

Chicago/Turabian Style

Guosheng Lin; Minyao Li; Nan Xu; Xiaoli Wu; Jingjing Liu; Yulin Wu; Qian Zhang; Jian Cai; Changjun Gao; Ziren Su. 2020. "Anti-Inflammatory Effects of Heritiera littoralis Fruits on Dextran Sulfate Sodium- (DSS-) Induced Ulcerative Colitis in Mice by Regulating Gut Microbiota and Suppressing NF-κB Pathway." BioMed Research International 2020, no. : 1-20.

Journal article
Published: 07 January 2020 in Journal of Ethnopharmacology
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Ulcerative colitis (UC) is tightly associated with inflammation response and oxidative stress. As a folk medicine applied in treatment of diarrhea, Bruguiera gymnorrhiza also possesses anti-inflammatory and anti-oxidative activities, which indicated that B. gymnorrhiza may exert anti-colitis effect. To investigate effect and mechanism of B. gymnorrhiza on experimental UC. Aqueous extract of B. gymnorrhiza leaves (ABL) was used for investigation in the present study. Murine UC was established through access to 3% dextran sulfate sodium (DSS) for 7 days. Meanwhile, mice accepted treatment with ABL (25, 50, 100 mg/kg) or sulfasalazine (200 mg/kg) once daily. On the last day, disease activity index (DAI) including body weight loss, fecal character and degree of bloody diarrhea was evaluated, colon segments were obtained for length measurement and further analysis and feces were collected for intestinal microbiota analysis. ABL ameliorated DAI scores, colon length shortening and histopathological damage in DSS-induced colitis mice obviously. SOD activity, levels of MDA and GSH altered by colitis were restored remarkably after ABL treatment. ABL inhibited increases in levels of colonic COX-2, iNOS, TNF-α, IL-6, IL-1β, IL-4, IL-10 and IL-11 in colitis mice. Moreover, ABL prominently suppressed NF-κB p65 and IκB phosphorylation and down-regulated mRNA levels of COX-2, iNOS, TNF-α, IL-6 and IL-1β elevated by colitis. As shown in microbiota analysis, ABL modulated composition of intestinal microbiota of colitis mice. ABL exhibited protective effect against DSS-induced ulcerative colitis through suppressing NF-κB activation and modulating intestinal microbiota.

ACS Style

Jin-Fen Chen; Dan-Dan Luo; Yin-Si Lin; Yu-Hong Liu; Jia-Zhen Wu; Xiao-Qing Yi; Yan Wu; Qian Zhang; Chang-Jun Gao; Jian Cai; Zi-Ren Su. Aqueous extract of Bruguiera gymnorrhiza leaves protects against dextran sulfate sodium induced ulcerative colitis in mice via suppressing NF-κB activation and modulating intestinal microbiota. Journal of Ethnopharmacology 2020, 251, 112554 .

AMA Style

Jin-Fen Chen, Dan-Dan Luo, Yin-Si Lin, Yu-Hong Liu, Jia-Zhen Wu, Xiao-Qing Yi, Yan Wu, Qian Zhang, Chang-Jun Gao, Jian Cai, Zi-Ren Su. Aqueous extract of Bruguiera gymnorrhiza leaves protects against dextran sulfate sodium induced ulcerative colitis in mice via suppressing NF-κB activation and modulating intestinal microbiota. Journal of Ethnopharmacology. 2020; 251 ():112554.

Chicago/Turabian Style

Jin-Fen Chen; Dan-Dan Luo; Yin-Si Lin; Yu-Hong Liu; Jia-Zhen Wu; Xiao-Qing Yi; Yan Wu; Qian Zhang; Chang-Jun Gao; Jian Cai; Zi-Ren Su. 2020. "Aqueous extract of Bruguiera gymnorrhiza leaves protects against dextran sulfate sodium induced ulcerative colitis in mice via suppressing NF-κB activation and modulating intestinal microbiota." Journal of Ethnopharmacology 251, no. : 112554.

Research article
Published: 19 June 2019 in Evidence-Based Complementary and Alternative Medicine
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Acute liver injury is a common consequence of taking overdose of acetaminophen (APAP). The aim of this study was to evaluate the antioxidant activity and hepatoprotective effect of a mangrove plant Sonneratia apetala fruit extract (SAFE) on APAP-induced liver injury in mice. Mice were orally pretreated with SAFE (100, 200, and 400 mg/kg) daily for one week. The control and APAP groups were intragastrically administered with distilled water, and NAC group was treated with N-Acetyl-L-cysteine (NAC) before APAP exposure. The results manifested that SAFE significantly improved survival rates, attenuated hepatic histological damage, and decreased the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in serum in APAP-exposed mice. SAFE treatment also increased glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity, enhanced catalase (CAT), and total antioxidant capacity (T-AOC), as well as reducing malondialdehyde (MDA) level in liver. In addition, the formation of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and elevation of myeloperoxidase (MPO) in APAP-exposed mice were inhibited after SAFE treatment. And SAFE also displayed high DPPH radical scavenging activity and reducing power in vitro. The main bioactive components of SAFE such as total phenol, flavonoid, condensed tannin, and carbohydrate were determined. The current study proved that SAFE exerted potential protective effect against APAP-induced acute liver injury, which might be associated with the antioxidant and anti-inflammatory activities of SAFE.

ACS Style

Jingjing Liu; Dandan Luo; Yulin Wu; Changjun Gao; Guosheng Lin; Jinfen Chen; Xiaoli Wu; Qian Zhang; Jian Cai; Ziren Su. The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice. Evidence-Based Complementary and Alternative Medicine 2019, 2019, 6919834 -12.

AMA Style

Jingjing Liu, Dandan Luo, Yulin Wu, Changjun Gao, Guosheng Lin, Jinfen Chen, Xiaoli Wu, Qian Zhang, Jian Cai, Ziren Su. The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice. Evidence-Based Complementary and Alternative Medicine. 2019; 2019 ():6919834-12.

Chicago/Turabian Style

Jingjing Liu; Dandan Luo; Yulin Wu; Changjun Gao; Guosheng Lin; Jinfen Chen; Xiaoli Wu; Qian Zhang; Jian Cai; Ziren Su. 2019. "The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice." Evidence-Based Complementary and Alternative Medicine 2019, no. : 6919834-12.

Research article
Published: 12 December 2018 in Evidence-Based Complementary and Alternative Medicine
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Acrostichum aureum Linn., a medicinal pteridophyte growing in mangrove forests and coastal regions of tropical and subtropical areas worldwide, has been proved to possess various biological effects. However, the protective effect of Acrostichum aureum Linn. against gastric ulcer still remains unidentified. Therefore, the gastroprotective effect of the water extract of Acrostichum aureum Linn. (WEAC) was investigated in ethanol-induced gastric injury model. According to our results, pretreatment with WEAC (100, 200, and 400 mg/kg) could dramatically decrease the ulcer areas and ameliorate the pathological damage induced by alcohol in rat’s gastric tissues. In addition, WEAC administration prevented the stomach from oxidative damage via markedly increasing the levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and decreasing the malondialdehyde (MDA). Besides, WEAC pretreatment alleviated inflammatory infiltration by reducing the secretion of proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) as well as decreasing the protein expressions of phosphorylation of IκBα and p65. Taken together, WEAC exerted potential therapeutic efficacy for gastric ulceration, and this may be involved in the suppression of oxidative stress and inflammatory response.

ACS Style

Xue Wu; Qionghui Huang; Nan Xu; Jian Cai; Dandan Luo; Qian Zhang; Ziren Su; Changjun Gao; Yuhong Liu. Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine 2018, 2018, 1 -10.

AMA Style

Xue Wu, Qionghui Huang, Nan Xu, Jian Cai, Dandan Luo, Qian Zhang, Ziren Su, Changjun Gao, Yuhong Liu. Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats. Evidence-Based Complementary and Alternative Medicine. 2018; 2018 ():1-10.

Chicago/Turabian Style

Xue Wu; Qionghui Huang; Nan Xu; Jian Cai; Dandan Luo; Qian Zhang; Ziren Su; Changjun Gao; Yuhong Liu. 2018. "Antioxidative and Anti-Inflammatory Effects of Water Extract of Acrostichum aureum Linn. against Ethanol-Induced Gastric Ulcer in Rats." Evidence-Based Complementary and Alternative Medicine 2018, no. : 1-10.

Journal article
Published: 09 April 2018 in Sustainability
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The chlorophyll content can indicate the general health of vegetation, and can be estimated from hyperspectral data. The aim of this study is to estimate the chlorophyll content of mangroves at different stages of restoration in a coastal wetland in Quanzhou, China, using proximal hyperspectral remote sensing techniques. We determine the hyperspectral reflectance of leaves from two mangrove species, Kandelia candel and Aegiceras corniculatum, from short-term and long-term restoration areas with a portable spectroradiometer. We also measure the leaf chlorophyll content (SPAD value). We use partial-least-squares stepwise regression to determine the relationships between the spectral reflectance and the chlorophyll content of the leaves, and establish two models, a full-wave-band spectrum model and a red-edge position regression model, to estimate the chlorophyll content of the mangroves. The coefficients of determination for the red-edge position model and the full-wave-band model exceed 0.72 and 0.82, respectively. The inverted chlorophyll contents are estimated more accurately for the long-term restoration mangroves than for the short-term restoration mangroves. Our results indicate that hyperspectral data can be used to estimate the chlorophyll content of mangroves at different stages of restoration, and could possibly be adapted to estimate biochemical constituents in leaves.

ACS Style

Zhiguo Dou; Lijuan Cui; Jing Li; Yinuo Zhu; Changjun Gao; Xu Pan; Yinru Lei; Manyin Zhang; Xinsheng Zhao; Wei Li. Hyperspectral Estimation of the Chlorophyll Content in Short-Term and Long-Term Restorations of Mangrove in Quanzhou Bay Estuary, China. Sustainability 2018, 10, 1127 .

AMA Style

Zhiguo Dou, Lijuan Cui, Jing Li, Yinuo Zhu, Changjun Gao, Xu Pan, Yinru Lei, Manyin Zhang, Xinsheng Zhao, Wei Li. Hyperspectral Estimation of the Chlorophyll Content in Short-Term and Long-Term Restorations of Mangrove in Quanzhou Bay Estuary, China. Sustainability. 2018; 10 (4):1127.

Chicago/Turabian Style

Zhiguo Dou; Lijuan Cui; Jing Li; Yinuo Zhu; Changjun Gao; Xu Pan; Yinru Lei; Manyin Zhang; Xinsheng Zhao; Wei Li. 2018. "Hyperspectral Estimation of the Chlorophyll Content in Short-Term and Long-Term Restorations of Mangrove in Quanzhou Bay Estuary, China." Sustainability 10, no. 4: 1127.