Traumatic brain injuries may cause intracranial hemorrhages (ICH). ICH could lead to disability or death if it is not accurately diagnosed and treated in a time-sensitive procedure. The current clinical protocol to diagnose ICH is examining Computerized Tomography (CT) scans by radiologists to detect ICH and localize its regions. However, this process relies heavily on the availability of an experienced radiologist. In this paper, we designed a study protocol to collect a dataset of 82 CT scans of subjects with a traumatic brain injury. Next, the ICH regions were manually delineated in each slice by a consensus decision of two radiologists. The dataset is publicly available online at the PhysioNet repository for future analysis and comparisons. In addition to publishing the dataset, which is the main purpose of this manuscript, we implemented a deep Fully Convolutional Networks (FCNs), known as U-Net, to segment the ICH regions from the CT scans in a fully-automated manner. The method as a proof of concept achieved a Dice coefficient of 0.31 for the ICH segmentation based on 5-fold cross-validation.

Tremor is one of the main symptoms of Parkinson’s Disease (PD) that reduces the quality of life. Tremor is measured as part of the Unified Parkinson Disease Rating Scale (UPDRS) part III. However, the assessment is based on onsite physical examinations and does not fully represent the patients’ tremor experience in their day-to-day life. Our objective in this paper was to develop algorithms that, combined with wearable sensors, can estimate total Parkinsonian tremor as the patients performed a variety of free body movements. We developed two methods: an ensemble model based on gradient tree boosting and a deep learning model based on long short-term memory (LSTM) networks. The developed methods were assessed on gyroscope sensor data from 24 PD subjects. Our analysis demonstrated that the method based on gradient tree boosting provided a high correlation (r = 0.96 using held-out testing and r = 0.93 using subject-based, leave-one-out cross-validation) between the estimated and clinically assessed tremor subscores in comparison to the LSTM-based method with a moderate correlation (r = 0.84 using held-out testing and r = 0.77 using subject-based, leave-one-out cross-validation). These results indicate that our approach holds great promise in providing a full spectrum of the patients’ tremor from continuous monitoring of the subjects’ movement in their natural environment.

According to the National Highway Traffic Safety Administration, one in ten fatal crashes and two in ten injury crashes were reported as distracted driver accidents in the United State during 2014. In an attempt to mitigate these alarming statistics, this paper explores using a dashboard camera along with computer vision and machine learning to automatically detect distracted drivers. We consider a dataset that incorporates drivers engaging in seven different distracting behaviors using left and/or right hands. Traditional handcrafted features paired with a Support Vector Machine classifier are contrasted with deep Convolutional Neural Networks. The traditional features include a blend of Histogram of Oriented Gradients and Scale-Invariant Feature Transform descriptors used to create Bags of Words. The deep convolutional methods use transfer learning on AlexNet, VGG-16, and ResNet-152. The results yield 85% accuracy with ResNet and 82.5% accuracy with VGG-16, which outperformed AlexNet by almost 10%. Replacing the fully connected layers by a Support Vector Machine classifier did not improve the classification accuracy. The traditional features yielded much lower accuracy than the deep convolutional networks.

Automated momentary estimation of positive and negative affects (PA and NA), the basic sense of feeling, can play an essential role in detecting the early signs of mood disorders. Physiological wearable sensors and machine learning have a potential to make such automated and continuous measurements. However, the physiological signals' features that are associated with the subject-reported PA or NA may not be known. In this work, we use data-driven feature extraction based on deep learning to investigate the application of raw physiological signals for estimating PA and NA. Specifically, we propose two multi-modal data fusion methods with deep Convolutional Neural Networks. We use the proposed architecture to estimate PA and NA and also classify baseline, stress, and amusement emotions. The training and evaluation of the methods are performed using four physiological and one chest motion signal modalities collected using a chest sensing unit from 15 subjects. Overall, our proposed model performed better than traditional machine learning on hand-crafted features. Utilizing only two modalities, our proposed model estimated PA with a correlation of 0.69 (P<; 0.05) vs. 0.59 (P<; 0.05) with traditional machine learning. These correlations were 0.79 (P<; 0.05) vs. 0.73 (P<; 0.05) for NA estimation. The best emotion classification was achieved by the traditional method with 79% F1-score and 80% accuracy when all the four physiological modalities are used. This is while with only two modalities, the deep learning achieved 78% F1-score and 79% accuracy.

Motor fluctuations between akinetic (medication OFF) and mobile phases (medication ON) states are one of the most prevalent complications of patients with Parkinson's disease (PD). There is a need for a technology-based system to provide reliable information about the duration in different medication phases that can be used by the treating physician to successfully adjust therapy. Two KinetiSense motion sensors were mounted on the most affected wrist and ankle of 19 PD subjects (age: 42-77, 14 males) and collected movement signals as the participants performed seven daily living activities in their medication OFF and ON phases. A feature selection and a classification algorithm based on support vector machine with fuzzy labeling was developed to detect medication ON/OFF states using gyroscope signals. The algorithm was trained using approximately 15% of the data from four activities and tested on the remaining data. The algorithm was able to detect medication ON and OFF states with 90.5% accuracy, 94.2% sensitivity, and 85.4% specificity. It performed equally well for all the activities with an average accuracy of 91.3% for the activities that were used in the training phase and 88.4% for the new activities. The developed sensor-based algorithm could provide objective and accurate assessment of medication states that can lead to successful adjustment of the therapy resulting in considerably improved care delivery and quality of life of PD patients.

Levodopa-induced dyskinesias are abnormal involuntary movements experienced by the majority of persons with Parkinson’s disease (PwP) at some point over the course of the disease. Choreiform as the most common phenomenology of levodopa-induced dyskinesias can be managed by adjusting the dose/frequency of PD medication(s) based on a PwP’s motor fluctuations over a typical day. We developed a sensor-based assessment system to provide such information. We used movement data collected from the upper and lower extremities of 15 PwPs along with a deep recurrent model to estimate dyskinesia severity as they perform different activities of daily living (ADL). Subjects performed a variety of ADLs during a 4-h period while their dyskinesia severity was rated by the movement disorder experts. The estimated dyskinesia severity scores from our model correlated highly with the expert-rated scores (r= 0.87 (p< 0.001)), which was higher than the performance of linear regression that is commonly used for dyskinesia estimation (r= 0.81 (p< 0.001)). Our model provided consistent performance at different ADLs with minimumr= 0.70 (during walking) to maximumr= 0.84 (drinking) in comparison to linear regression withr= 0.00 (walking) tor= 0.76 (cutting food). These findings suggest that when our model is applied to at-home sensor data, it can provide an accurate picture of changes of dyskinesia severity facilitating effective medication adjustments.