Prof. Maurizio Casarrubea
University of Palermo (Palermo, Italy)
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Academic Career Length
27Years (2000-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 January 2015 in Journal of Neuroscience Methods
Journal Article
Maurizio CasarrubeaGJG.K. Jonsson
G.K. JonssonFFF. Faulisi
F. FaulisiFSF. Sorbera
F. Sorbera
Giuseppe Di GiovanniMMMagnusson Sigurdur Magnusson
Magnusson Sigurdur Magnusson +2
1 January 2013 in Behavioural Brain Research
Journal Article
Maurizio CasarrubeaVRV. Roy
V. RoyFSF. Sorbera
F. Sorbera
MMM.S. Magnusson
M.S. Magnusson
ASA. Santangelo
A. SantangeloGCG. Crescimanno
G. Crescimanno
+1
1 June 2015 in Frontiers in Cellular Neuroscience
Journal Article
Maurizio CasarrubeaCDCaitlin Davies
Caitlin Davies
FFFabiana Faulisi
Fabiana Faulisi
MPMassimo Pierucci
Massimo Pierucci
RCRoberto Colangeli
Roberto ColangeliGiuseppe Di Giovanni +7
Nicotine is one of the most addictive drugs of abuse. Tobacco smoking is a major cause of many health problems, and is the first preventable cause of death worldwide. Several findings show that nicotine exerts significant aversive as well as the well-known rewarding motivational effects. Less certain is the anatomical substrate that mediates or enables nicotine aversion. Here, we show that acute nicotine induces anxiogenic effects in rats at the doses investigated (0.1, 0.5, and 1.0 mg/kg, i.p.), as measured by the hole-board apparatus and manifested in behaviors such as decreased rearing and head-dipping and increased grooming. No changes in locomotor behavior were observed at any of the nicotine doses given. T-pattern analysis of the behavioral outcomes revealed a drastic reduction and disruption of complex behavioral patterns induced by all three nicotine doses, with the maximum effect for 1 mg/kg. Lesion of the lateral habenula (LHb) induced hyperlocomotion and, strikingly, reversed the nicotine-induced anxiety obtained at 1 mg/kg to an anxiolytic-like effect, as shown by T-pattern analysis. We suggest that the LHb is critically involved in emotional behavior states and in nicotine-induced anxiety, most likely through modulation of monoaminergic nuclei.
1 December 2018 in Journal of Neuroscience Methods
Journal Article
Maurizio CasarrubeaMMM.S. Magnusson
M.S. Magnusson
MAM. Teresa Anguera
M. Teresa AngueraGJG.K. Jonsson
G.K. Jonsson
MCMarta Castañer
Marta CastañerGCG. Crescimanno
G. Crescimanno
+8
1 January 2009 in Physiology & Behavior
Journal Article
Maurizio CasarrubeaFSFilippina Sorbera
Filippina Sorbera
GCGiuseppe Crescimanno
Giuseppe Crescimanno
1 March 2009 in Physiology & Behavior
Journal Article
Maurizio CasarrubeaFSFilippina Sorbera
Filippina Sorbera
GCGiuseppe Crescimanno
Giuseppe Crescimanno
About Me
Maurizio Casarrubea, MD, PhD, serves as Associate Professor at the University of Palermo - Italy, Institute of Human Physiology “Giuseppe Pagano”, Laboratory of Behavioral Physiology, Department of Biomedicine Neuroscience and Advanced Diagnostics (Bi.N.D.). He graduated from the University of Palermo with degrees in Medicine and Surgery, a Medical Specialization in Sport Medicine and a PhD in Neurosensorial Physiopathology.
Professor Maurizio Casarrubea currently teaches Human Physiology in various Degree Courses of the School of Medicine and Surgery of the University of Palermo. He has authored or co-authored numerous research papers, book chapters, and conference proceedings related to the study of anxiety-related behavior, the relationships between anxiety and pain, and the behavioral effects produced by the administration of psychoactive drugs. In addition, he regularly presents the results of his experiments to various congresses of Neurosciences and Behavioral Sciences. His current research activity is funded by the University of Palermo and is focused on the application of multivariate approaches to the study of anxiety-related behavior in rodents. He is member of the Mediterranean Neuroscience Society (M.N.S.) and of the Technologies of Knowledge Interdepartmental Center (C.I.T.C.), University of Palermo.