Pasquale Longo

Prof. Pasquale Longo

Department of Chemistry and Biology "A. Zambelli", University of Salerno, Fisciano, Italy
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Research Focus & Metrics

Academic Career Length

42Years (1985-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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29 June 2021 in Applied Sciences
Verified
Journal Article
Open access
PDF file
ACAlessia Catalano
Alessia Catalano
Maria Stefania SinicropiMaria Stefania Sinicropi
Maria Stefania Sinicropi
Domenico IacopettaDomenico Iacopetta
Domenico Iacopetta
Jessica CeramellaJessica Ceramella
Jessica Ceramella
Annaluisa MaricondaAnnaluisa Mariconda
Annaluisa Mariconda
Pasquale LongoPasquale Longo
Pasquale Longo
Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.


1 May 1997 in Journal of the American Chemical Society
Verified
Journal Article
Closed access
GGGaetano Guerra
Gaetano Guerra
Pasquale LongoPasquale Longo
Pasquale Longo
LCLuigi Cavallo
Luigi Cavallo
PCPaolo Corradini
Paolo Corradini
LRLuigi Resconi
Luigi Resconi

1 September 1995 in Macromolecular Chemistry and Physics
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Journal Article
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Pasquale LongoPasquale Longo
Pasquale Longo
APAntonio Proto
Antonio Proto
AZAdolfo Zambelli
Adolfo Zambelli

1 January 1989 in Macromolecules
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Journal Article
Closed access
Alfonso GrassiAlfonso Grassi
Alfonso Grassi
Pasquale LongoPasquale Longo
Pasquale Longo
APAntonio Proto
Antonio Proto
AZAdolfo Zambelli
Adolfo Zambelli

30 May 2022 in Antibiotics
Verified
Journal Article
Open access
PDF file
Maria Stefania SinicropiMaria Stefania Sinicropi
Maria Stefania Sinicropi
Domenico IacopettaDomenico Iacopetta
Domenico Iacopetta
Jessica CeramellaJessica Ceramella
Jessica Ceramella
ACAlessia Catalano
Alessia Catalano
Annaluisa MaricondaAnnaluisa Mariconda
Annaluisa Mariconda
Stefano AquaroStefano Aquaro
Stefano Aquaro
Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal care products, medical products, plastic cutting boards, and food storage containers. Colgate Total® toothpaste, containing 10 mM TCS, is effective in controlling biofilm formation and maintaining gingival health. Given its broad usage, TCS is present ubiquitously in the environment. Given its strong lipophilicity and accumulation ability in organisms, it is potentially harmful to biohealth. Several reports suggest the toxicity of this compound, which is inserted in the class of endocrine disrupting chemicals (EDCs). In September 2016, TCS was banned by the U.S. Food and Drug Administration (FDA) and the European Union in soap products. Despite these problems, its application in personal care products within certain limits is still allowed. Today, it is still unclear whether TCS is truly toxic to mammals and the adverse effects of continuous, long-term, and low concentration exposure remain unknown. Indeed, some recent reports suggest the use of TCS as a repositioned drug for cancer treatment and cutaneous leishmaniasis. In this scenario it is necessary to investigate the advantages and disadvantages of TCS, to understand whether its use is advisable or not. This review intends to highlight the pros and cons that are associated with the use of TCS in humans.