Costas Demetzos

Prof. Costas Demetzos

Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece
orcid

Research Focus & Metrics

Academic Career Length

38Years (1989-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2008 in Journal of Liposome Research
Verified
Journal Article
Closed access
M. R. MozafariM. R. Mozafari
M. R. Mozafari
CJChad Johnson
Chad Johnson
Sophia HatziantoniouSophia Hatziantoniou
Sophia Hatziantoniou
Costas DemetzosCostas Demetzos
Costas Demetzos
Food nanotechnology involves the utilization of nanocarrier systems to stabilize the bioactive materials against a range of environmental and chemical changes as well as to improve their bioavailability. Nanoliposome technology presents exciting opportunities for food technologists in areas such as encapsulation and controlled release of food materials, as well as the enhanced bioavailability, stability, and shelf-life of sensitive ingredients. Liposomes and nanoliposomes have been used in the food industry to deliver flavors and nutrients and, more recently, have been investigated for their ability to incorporate antimicrobials that could aid in the protection of food products against microbial contamination. In this paper, the main physicochemical properties of liposomes and nanoliposomes are described and some of the industrially applicable methods for their manufacture are reviewed. A summary of the application of nanoliposomes as carrier vehicles of nutrients, nutraceuticals, enzymes, food additives, and food antimicrobials is also presented.

1 January 2008 in Journal of Liposome Research
Verified
Journal Article
Closed access
Costas DemetzosCostas Demetzos
Costas Demetzos
Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process. The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using thermal analysis. Differential Scanning Calorimetry (DSC) is a suitable thermal analysis technique for determining the purity, the polymorphic forms and the melting point of a sample in the Pharmaceutical Industry. It is also considered as a tool to study the thermal behavior of lipid bilayers and of lipidic drug delivery systems, like liposomes by measuring thermodynamic parameters (i.e. DeltaH and Tm), which affect the stability of the liposomal suspension under given storage conditions.

1 October 2003 in Phytochemistry
Verified
Journal Article
Closed access
HSHelen D. Skaltsa
Helen D. Skaltsa
Costas DemetzosCostas Demetzos
Costas Demetzos
DLDiamanto Lazari
Diamanto Lazari
MSMarina Sokovic
Marina Sokovic

11 May 2009 in International Journal of Cosmetic Science
Verified
Journal Article
Closed access
PDF file
ATHANASIA VARVARESOUATHANASIA VARVARESOU
ATHANASIA VARVARESOU
Spyros PapageorgiouSpyros Papageorgiou
Spyros Papageorgiou
ETE. Tsirivas
E. Tsirivas
EPE. Protopapa
E. Protopapa
HKH. Kintziou
H. Kintziou
Costas DemetzosCostas Demetzos
Costas Demetzos

1 August 2006 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
KGKonstantinos Gardikis
Konstantinos Gardikis
Sophia HatziantoniouSophia Hatziantoniou
Sophia Hatziantoniou
KVKyriakos Viras
Kyriakos Viras
MWMatthias Wagner
Matthias Wagner
Costas DemetzosCostas Demetzos
Costas Demetzos

1 April 1998 in Planta Medica
Verified
Journal Article
Closed access
PDF file
KDKostas Dimas
Kostas Dimas
Costas DemetzosCostas Demetzos
Costas Demetzos
MMMarios Marsellos
Marios Marsellos
RSRoula Sotiriadou
Roula Sotiriadou
MMMixalis Malamas
Mixalis Malamas
DKDimitrios Kokkinopoulos
Dimitrios Kokkinopoulos
Nine labdane type diterpenes isolated from the plant Cistus creticus subsp. creticus and from the resin “Ladano” which is excreted on the surface of the leaves and stems of this plant, were examined for their in vitro cytotoxic activity against 14 human leukemic cell lines. Compound 1, (13E)-labd-13-ene-8α,15-diol, exhibited cytotoxic activity against 13 of the cell lines tested, while compound 2, (13E)-labd-7,13-dienol, was active only against HL60 cells. Further compound 1 was examined for its effect on the uptake of [3 H]-thymidine as a marker of DNA synthesis.