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Rice lesion mimic mutants (LMMs) form spontaneous lesions on the leaves during vegetative growth without pathogenic infections. The rice LMM group includes various mutants, including spotted leaf mutants, brown leaf mutants, white-stripe leaf mutants, and other lesion-phenotypic mutants. These LMM mutants exhibit a common phenotype of lesions on the leaves linked to chloroplast destruction caused by the eruption of reactive oxygen species (ROS) in the photosynthesis process. This process instigates the hypersensitive response (HR) and programmed cell death (PCD), resulting in lesion formation. The reasons for lesion formation have been studied extensively in terms of genetics and molecular biology to understand the pathogen and stress responses. In rice, the lesion phenotypes of most rice LMMs are inherited according to the Mendelian principles of inheritance, which remain in the subsequent generations. These rice LMM genetic traits have highly developed innate self-defense mechanisms. Thus, although rice LMM plants have undesirable agronomic traits, the genetic principles of LMM phenotypes can be used to obtain high grain yields by deciphering the efficiency of photosynthesis, disease resistance, and environmental stress responses. From these ailing rice LMM plants, rice geneticists have discovered novel proteins and physiological causes of ROS in photosynthesis and defense mechanisms. This review discusses recent studies on rice LMMs for the Mendelian inheritances, molecular genetic mapping, and the genetic definition of each mutant gene.
Sang Kang; Kyung Lee; Mahendra Singh; Pradeep Kumar; Mohammad Matin. Rice Lesion Mimic Mutants (LMM): The Current Understanding of Genetic Mutations in the Failure of ROS Scavenging during Lesion Formation. Plants 2021, 10, 1598 .
AMA StyleSang Kang, Kyung Lee, Mahendra Singh, Pradeep Kumar, Mohammad Matin. Rice Lesion Mimic Mutants (LMM): The Current Understanding of Genetic Mutations in the Failure of ROS Scavenging during Lesion Formation. Plants. 2021; 10 (8):1598.
Chicago/Turabian StyleSang Kang; Kyung Lee; Mahendra Singh; Pradeep Kumar; Mohammad Matin. 2021. "Rice Lesion Mimic Mutants (LMM): The Current Understanding of Genetic Mutations in the Failure of ROS Scavenging during Lesion Formation." Plants 10, no. 8: 1598.
Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational and medicinal purposes. In many countries, cannabis-based medicines have been legalized under certain conditions because of their immense prospects in medicinal applications. With a comprehensive insight into the prospects and challenges associated with the pharmacological use and global trade of C. sativa, this mini-review focuses on the medicinal importance of the plant and its legal status worldwide; the pharmacological compounds and its therapeutic potential along with the underlying public health concerns and future perspective are herein discussed. The existence of major compounds including Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol, cannabinol, and cannabichromene contributes to the medicinal effects of the cannabis plant. These compounds are also involved in the treatment of various types of cancer, epilepsy, and Parkinson's disease displaying several mechanisms of action. Cannabis sativa is a plant with significant pharmacological potential. However, several aspects of the plant need an in-depth understanding of the drug mechanism and its interaction with other drugs. Only after addressing these health concerns, legalization of cannabis could be utilized to its full potential as a future medicine.
Pradeep Kumar; Dipendra Kumar Mahato; Madhu Kamle; Rituraj Borah; Bharti Sharma; Shikha Pandhi; Vijay Tripathi; Hardeo Singh Yadav; Sheetal Devi; Umesh Patil; Jianbo Xiao; Awdhesh Kumar Mishra. Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview. Phytotherapy Research 2021, 1 .
AMA StylePradeep Kumar, Dipendra Kumar Mahato, Madhu Kamle, Rituraj Borah, Bharti Sharma, Shikha Pandhi, Vijay Tripathi, Hardeo Singh Yadav, Sheetal Devi, Umesh Patil, Jianbo Xiao, Awdhesh Kumar Mishra. Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview. Phytotherapy Research. 2021; ():1.
Chicago/Turabian StylePradeep Kumar; Dipendra Kumar Mahato; Madhu Kamle; Rituraj Borah; Bharti Sharma; Shikha Pandhi; Vijay Tripathi; Hardeo Singh Yadav; Sheetal Devi; Umesh Patil; Jianbo Xiao; Awdhesh Kumar Mishra. 2021. "Pharmacological properties, therapeutic potential, and legal status of Cannabis sativa L.: An overview." Phytotherapy Research , no. : 1.
Background Bacillus thuringiensis (Bt) has been used in agriculture for a long time because of its insecticidal proteins which make it a valuable environment-friendly biopesticide. However, its use is not only limited to insecticidal properties. Current and previous studies indicate its potential as a biofertilizer for promoting plant growth, the development of transgenic plants, and others. It is the presence of δ-endotoxins, especially cry protein, which attributes the insecticidal property to the bacteria. Besides, there are some vegetative and secreted insecticidal proteins that exert their toxic activity towards specific species. Main body of abstract The present review briefly provides an overview of the Bt uses and application as a biocontrol agent against insect pest for sustainable agriculture. Historical development of Bt as biocontrol, classification of various cry proteins, their mechanisms of actions against different insect-pest, and incorporation of cry genes in the plant for developing transgenic Bt plants such as Bt cotton, potato, and maize. Applications of Bt as biofertilizer and the various bioformulations as biopesticide are also described. Short conclusion Uses of harmful pesticides and chemical cause various health issues and environmental problem; therefore, the Bt served as the best alternative to overcome the above issue. Also, we aim to explore the potential as plant growth-promoting potential and solubilization of minerals and the uses as a biofertilizer, keeping the high specificity and environmental safety of Bt. Its various formulations are commercially available and considered an efficient alternative to chemical pesticides.
Pradeep Kumar; Madhu Kamle; Rituraj Borah; Dipendra Kumar Mahato; Bharti Sharma. Bacillus thuringiensis as microbial biopesticide: uses and application for sustainable agriculture. Egyptian Journal of Biological Pest Control 2021, 31, 1 -7.
AMA StylePradeep Kumar, Madhu Kamle, Rituraj Borah, Dipendra Kumar Mahato, Bharti Sharma. Bacillus thuringiensis as microbial biopesticide: uses and application for sustainable agriculture. Egyptian Journal of Biological Pest Control. 2021; 31 (1):1-7.
Chicago/Turabian StylePradeep Kumar; Madhu Kamle; Rituraj Borah; Dipendra Kumar Mahato; Bharti Sharma. 2021. "Bacillus thuringiensis as microbial biopesticide: uses and application for sustainable agriculture." Egyptian Journal of Biological Pest Control 31, no. 1: 1-7.
The mycotoxin patulin is primarily produced as a secondary metabolite by numerous fungal species and predominantly by Aspergillus, Byssochlamys, and Penicillium species. It is generally associated with fungal infected food materials. Penicillium expansum is considered the only fungal species liable for patulin contamination in pome fruits, especially in apples and apple-based products. This toxin in food poses serious health concerns and economic threat, which has aroused the need to adopt effective detection and mitigation strategies. Understanding its origin sources and biosynthetic mechanism stands essential for efficiently designing a management strategy against this fungal contamination. This review aims to present an updated outline of the sources of patulin occurrence in different foods and their biosynthetic mechanisms. It further provides information regarding the detrimental effects of patulin on human and agriculture as well as its effective detection, management, and control strategies.
Dipendra Kumar Mahato; Madhu Kamle; Bharti Sharma; Shikha Pandhi; Sheetal Devi; Kajal Dhawan; Raman Selvakumar; Diwakar Mishra; Arvind Kumar; Shalini Arora; Namita Ashish Singh; Pradeep Kumar. Patulin in food: A mycotoxin concern for human health and its management strategies. Toxicon 2021, 198, 12 -23.
AMA StyleDipendra Kumar Mahato, Madhu Kamle, Bharti Sharma, Shikha Pandhi, Sheetal Devi, Kajal Dhawan, Raman Selvakumar, Diwakar Mishra, Arvind Kumar, Shalini Arora, Namita Ashish Singh, Pradeep Kumar. Patulin in food: A mycotoxin concern for human health and its management strategies. Toxicon. 2021; 198 ():12-23.
Chicago/Turabian StyleDipendra Kumar Mahato; Madhu Kamle; Bharti Sharma; Shikha Pandhi; Sheetal Devi; Kajal Dhawan; Raman Selvakumar; Diwakar Mishra; Arvind Kumar; Shalini Arora; Namita Ashish Singh; Pradeep Kumar. 2021. "Patulin in food: A mycotoxin concern for human health and its management strategies." Toxicon 198, no. : 12-23.
The disposal of municipal solid waste (MSW) directly at landfills or open dump areas, without segregation and treatment, is a significant concern due to its hazardous contents of antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARGs), and metal resistance genes (MGEs). The released leachate from landfills greatly effects the soil physicochemical, biological, and groundwater properties associated with agricultural activity and human health. The abundance of ARB, ARGs, and MGEs have been reported worldwide, including MSW landfill sites, animal husbandry, wastewater, groundwater, soil, and aerosol. This review elucidates the occurrence and abundance of ARB, ARGs, and MRGs, which are regarded as emerging contaminants (ECs). Recently, ECs have received global attention because of their prevalence in leachate as a substantial threat to environmental and public health, including an economic burden for developing nations. The present review exclusively discusses the demands to develop a novel eco-friendly management strategy to combat these global issues. This review also gives an intrinsic discussion about the insights of different aspects of environmental and public health concerns caused due to massive leachate generation, the abundance of antibiotics resistance (AR), and the effects of released leachate on the various environmental reservoirs and human health. Furthermore, the current review throws light on the source and fate of different ECs of landfill leachate and their possible impact on the nearby environments (groundwater, surface water, and soil) affecting human health. The present review strongly suggests the demand for future research focuses on the advancement of the removal efficiency of contaminants with the improvement of relevant landfill management to reduce the potential effects of disposable waste. We propose the necessity of the identification and monitoring of potential environmental and human health risks associated with landfill leachate contaminants.
Uttpal Anand; Bhaskar Reddy; Vipin Singh; Amit Singh; Kavindra Kesari; Pooja Tripathi; Pradeep Kumar; Vijay Tripathi; Jesus Simal-Gandara. Potential Environmental and Human Health Risks Caused by Antibiotic-Resistant Bacteria (ARB), Antibiotic Resistance Genes (ARGs) and Emerging Contaminants (ECs) from Municipal Solid Waste (MSW) Landfill. Antibiotics 2021, 10, 374 .
AMA StyleUttpal Anand, Bhaskar Reddy, Vipin Singh, Amit Singh, Kavindra Kesari, Pooja Tripathi, Pradeep Kumar, Vijay Tripathi, Jesus Simal-Gandara. Potential Environmental and Human Health Risks Caused by Antibiotic-Resistant Bacteria (ARB), Antibiotic Resistance Genes (ARGs) and Emerging Contaminants (ECs) from Municipal Solid Waste (MSW) Landfill. Antibiotics. 2021; 10 (4):374.
Chicago/Turabian StyleUttpal Anand; Bhaskar Reddy; Vipin Singh; Amit Singh; Kavindra Kesari; Pooja Tripathi; Pradeep Kumar; Vijay Tripathi; Jesus Simal-Gandara. 2021. "Potential Environmental and Human Health Risks Caused by Antibiotic-Resistant Bacteria (ARB), Antibiotic Resistance Genes (ARGs) and Emerging Contaminants (ECs) from Municipal Solid Waste (MSW) Landfill." Antibiotics 10, no. 4: 374.
Plants of the genus Brassica occupy the top place among vegetables in the world. This genus, which contains a group of six related species of a global economic significance, three of which are diploid: Brassica nigra (L.) K. Koch, Brassica oleracea L., and Brassica rapa L. and three are amphidiploid species: Brassica carinata A. Braun, Brassica juncea (L.) Czern., and Brassica napus L. These varieties are divided into oily, fodder, spice, and vegetable based on their morphological structure, chemical composition, and usefulness of plant organs. The present review provides information about habitat, phytochemical composition, and the bioactive potential of Brassica plants, mainly antioxidant, antimicrobial, anticancer activities, and clinical studies in human. Brassica vegetables are of great economic importance around the world. At present, Brassica plants are grown together with cereals and form the basis of global food supplies. They are distinguished by high nutritional properties from other vegetable plants, such as low fat and protein content and high value of vitamins, fibers along with minerals. In addition, they possess several phenolic compounds and have a unique type of compounds namely glucosinolates that differentiate these crops from other vegetables. These compounds are also responsible for numerous biological activities to the genus Brassica as described in this review.
Bahare Salehi; Cristina Quispe; Monica Butnariu; Ioan Sarac; Ilias Marmouzi; Madhu Kamle; Vijay Tripathi; Pradeep Kumar; Abdelhakim Bouyahya; Esra Capanoglu; Fatma Duygu Ceylan; Laxman Singh; Indra D. Bhatt; Barbara Sawicka; Barbara Krochmal‐Marczak; Dominika Skiba; Meryem El Jemli; Yousra El Jemli; Ericsson Coy‐Barrera; Javad Sharifi‐Rad; Senem Kamiloglu; María De La Luz Cádiz‐Gurrea; Antonio Segura‐Carretero; Manoj Kumar; Miquel Martorell. Phytotherapy and food applications from Brassica genus. Phytotherapy Research 2021, 35, 3590 -3609.
AMA StyleBahare Salehi, Cristina Quispe, Monica Butnariu, Ioan Sarac, Ilias Marmouzi, Madhu Kamle, Vijay Tripathi, Pradeep Kumar, Abdelhakim Bouyahya, Esra Capanoglu, Fatma Duygu Ceylan, Laxman Singh, Indra D. Bhatt, Barbara Sawicka, Barbara Krochmal‐Marczak, Dominika Skiba, Meryem El Jemli, Yousra El Jemli, Ericsson Coy‐Barrera, Javad Sharifi‐Rad, Senem Kamiloglu, María De La Luz Cádiz‐Gurrea, Antonio Segura‐Carretero, Manoj Kumar, Miquel Martorell. Phytotherapy and food applications from Brassica genus. Phytotherapy Research. 2021; 35 (7):3590-3609.
Chicago/Turabian StyleBahare Salehi; Cristina Quispe; Monica Butnariu; Ioan Sarac; Ilias Marmouzi; Madhu Kamle; Vijay Tripathi; Pradeep Kumar; Abdelhakim Bouyahya; Esra Capanoglu; Fatma Duygu Ceylan; Laxman Singh; Indra D. Bhatt; Barbara Sawicka; Barbara Krochmal‐Marczak; Dominika Skiba; Meryem El Jemli; Yousra El Jemli; Ericsson Coy‐Barrera; Javad Sharifi‐Rad; Senem Kamiloglu; María De La Luz Cádiz‐Gurrea; Antonio Segura‐Carretero; Manoj Kumar; Miquel Martorell. 2021. "Phytotherapy and food applications from Brassica genus." Phytotherapy Research 35, no. 7: 3590-3609.
A severe acute respiratory syndrome is an unusual type of contagious pneumonia that is caused by SARS coronavirus. At present, the whole world is trying to combat this coronavirus disease and scientific communities are putting rigorous efforts to develop vaccines. However, there are only a few specific medical treatments for SARS‐CoV‐2. Apart from other public health measures taken to prevent this virus, we can boost our immunity with natural products. In this article, we have highlighted the potential of common spices and herbs as antiviral agents and immunity boosters. A questionnaire‐based online survey has been conducted on home remedies during COVID‐19 among a wide range of peoples (n‐531) of different age groups (13–68 years) from various countries. According to the survey, 71.8% of people are taking kadha for combating infection and boosting immunity. Most people (86.1%) think that there is no side effect of kadha while 13.9% think vice versa. A total of 93.6% of people think that spices are helpful in curing coronavirus or other viral infection as well as boosting immunity. Most people are using tulsi drops, vitamin C, and chyawanprash for boosting their immunity. Therefore, we conclude from the survey and available literature that spices and herbs play a significant role against viral infections.
Namita Ashish Singh; Pradeep Kumar; Jyoti; Naresh Kumar. Spices and herbs: Potential antiviral preventives and immunity boosters during COVID ‐19. Phytotherapy Research 2021, 35, 2745 -2757.
AMA StyleNamita Ashish Singh, Pradeep Kumar, Jyoti, Naresh Kumar. Spices and herbs: Potential antiviral preventives and immunity boosters during COVID ‐19. Phytotherapy Research. 2021; 35 (5):2745-2757.
Chicago/Turabian StyleNamita Ashish Singh; Pradeep Kumar; Jyoti; Naresh Kumar. 2021. "Spices and herbs: Potential antiviral preventives and immunity boosters during COVID ‐19." Phytotherapy Research 35, no. 5: 2745-2757.
Mycotoxins represent an assorted range of secondary fungal metabolites that extensively occur in numerous food and feed ingredients at any stage during pre- and post-harvest conditions. Zearalenone (ZEN), a mycotoxin categorized as a xenoestrogen poses structural similarity with natural estrogens that enables its binding to the estrogen receptors leading to hormonal misbalance and numerous reproductive diseases. ZEN is mainly found in crops belonging to temperate regions, primarily in maize and other cereal crops that form an important part of various food and feed. Because of the significant adverse effects of ZEN on both human and animal, there is an alarming need for effective detection, mitigation, and management strategies to assure food and feed safety and security. The present review tends to provide an updated overview of the different sources, occurrence and biosynthetic mechanisms of ZEN in various food and feed. It also provides insight to its harmful effects on human health and agriculture along with its effective detection, management, and control strategies.
Dipendra Mahato; Sheetal Devi; Shikha Pandhi; Bharti Sharma; Kamlesh Maurya; Sadhna Mishra; Kajal Dhawan; Raman Selvakumar; Madhu Kamle; Awdhesh Mishra; Pradeep Kumar. Occurrence, Impact on Agriculture, Human Health, and Management Strategies of Zearalenone in Food and Feed: A Review. Toxins 2021, 13, 92 .
AMA StyleDipendra Mahato, Sheetal Devi, Shikha Pandhi, Bharti Sharma, Kamlesh Maurya, Sadhna Mishra, Kajal Dhawan, Raman Selvakumar, Madhu Kamle, Awdhesh Mishra, Pradeep Kumar. Occurrence, Impact on Agriculture, Human Health, and Management Strategies of Zearalenone in Food and Feed: A Review. Toxins. 2021; 13 (2):92.
Chicago/Turabian StyleDipendra Mahato; Sheetal Devi; Shikha Pandhi; Bharti Sharma; Kamlesh Maurya; Sadhna Mishra; Kajal Dhawan; Raman Selvakumar; Madhu Kamle; Awdhesh Mishra; Pradeep Kumar. 2021. "Occurrence, Impact on Agriculture, Human Health, and Management Strategies of Zearalenone in Food and Feed: A Review." Toxins 13, no. 2: 92.
Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines throughout India since ancient times. All the parts of the plant are immensely useful due to the presence of different compounds of pharmaceutical importance belonging to various groups as alkaloids, diterpenoid lactones, glycosides, steroids, sesquiterpenoid, and phenolics. These compounds possess pharmacological properties, which make it anti-diabetic, antipyretic, anti-inflammatory, anti-oxidant, hepato-protective, and immuno-modulatory. However, due to the increasing population, there is an inadequate supply of drugs. Therefore, this review focuses on phytochemistry, ethnopharmacology, clinical application and its conservation strategies so that the plant can be conserved for future generations and utilized as alternative medicine as well as to design various pharmacologically important drugs.
Pradeep Kumar; Madhu Kamle; Dipendra Kumar Mahato; Himashree Bora; Bharti Sharma; Prasad Rasane; Vivek K. Bajpai. Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies. Current Pharmaceutical Biotechnology 2020, 21, 1165 -1175.
AMA StylePradeep Kumar, Madhu Kamle, Dipendra Kumar Mahato, Himashree Bora, Bharti Sharma, Prasad Rasane, Vivek K. Bajpai. Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies. Current Pharmaceutical Biotechnology. 2020; 21 (12):1165-1175.
Chicago/Turabian StylePradeep Kumar; Madhu Kamle; Dipendra Kumar Mahato; Himashree Bora; Bharti Sharma; Prasad Rasane; Vivek K. Bajpai. 2020. "Tinospora cordifolia (Giloy): Phytochemistry, Ethnopharmacology, Clinical Application and Conservation Strategies." Current Pharmaceutical Biotechnology 21, no. 12: 1165-1175.
Ochratoxins (OTs) are a group of mycotoxins produced by Aspergillus and Penicillium spp. which are ubiquitous. They infect the crops during pre- and post-harvest conditions and contaminate various food and feed. Among all the OTs produced, ochratoxin A (OTA) poses serious health issues like neurotoxicity and carcinogenesis. The harmful impact of the toxins is observed in both humans and animals. The toxins get accumulated in the organs of animals through the contaminated animal-feed which further contaminate the products derived from them, such as milk and meat-based products. Therefore, sensitive and robust identification, detection, and quantification methods along with efficient management and control measures are crucial. Spectrometric and spectroscopy techniques are quite sensitive and lead to better detection of the toxin in the food products. Control and preventive measures during harvesting, storage and transportation are found to be effective in managing the production of such toxins. This review insight on the occurrence, chemistry, biosynthesis, effects on human health and agriculture, detections, management, and control strategies of ochratoxins.
Pradeep Kumar; Dipendra Kumar Mahato; Bharti Sharma; Rituraj Borah; Shafiul Haque; M.M. Chayan Mahmud; Ajay Kumar Shah; Deepaksshi Rawal; Himashree Bora; Sukni Bui. Ochratoxins in food and feed: Occurrence and its impact on human health and management strategies. Toxicon 2020, 187, 151 -162.
AMA StylePradeep Kumar, Dipendra Kumar Mahato, Bharti Sharma, Rituraj Borah, Shafiul Haque, M.M. Chayan Mahmud, Ajay Kumar Shah, Deepaksshi Rawal, Himashree Bora, Sukni Bui. Ochratoxins in food and feed: Occurrence and its impact on human health and management strategies. Toxicon. 2020; 187 ():151-162.
Chicago/Turabian StylePradeep Kumar; Dipendra Kumar Mahato; Bharti Sharma; Rituraj Borah; Shafiul Haque; M.M. Chayan Mahmud; Ajay Kumar Shah; Deepaksshi Rawal; Himashree Bora; Sukni Bui. 2020. "Ochratoxins in food and feed: Occurrence and its impact on human health and management strategies." Toxicon 187, no. : 151-162.
A protoberberine alkaloid, (−)-tetrahydroberberrubine∙acetate (THBA) was assessed for its antioxidant potential and ability to inhibit the growth of a food hazard bacterium Bacillus cereus in vitro and in situ. THBA displayed significant and dose-dependent cellular antioxidant potential against hydrogen peroxide-induced oxidative stress in NIH 3T3 fibroblast cells and decreased the ROS levels as well as increased the expression levels of SOD1 and SOD2 enzymes. The inhibitory spectrum of THBA confirmed its mechanistic role in the disruption of the membrane integrity of B. cereus as evidenced by the results of time-inactivation, cell membrane integrity, NPN membrane uptake, membrane potential, and electron microscopy analyses. Moreover, THBA inhibited biofilm formation by B. cereus and disrupted pre-established biofilms on a glass surface. Furthermore, THBA was also able to inhibit B. cereus in raw rice with a significant amount of reduction in CFU counts, suggesting its potential role as a natural antioxidant and antimicrobial agent.
Vivek K. Bajpai; Inwha Park; Imran Khan; Fanar Hamad Alshammari; Pradeep Kumar; Lei Chen; MinKyun Na; Yun Suk Huh; Young-Kyu Han; Shruti Shukla. (−)-Tetrahydroberberrubine∙acetate accelerates antioxidant potential and inhibits food associated Bacillus cereus in rice. Food Chemistry 2020, 339, 127902 .
AMA StyleVivek K. Bajpai, Inwha Park, Imran Khan, Fanar Hamad Alshammari, Pradeep Kumar, Lei Chen, MinKyun Na, Yun Suk Huh, Young-Kyu Han, Shruti Shukla. (−)-Tetrahydroberberrubine∙acetate accelerates antioxidant potential and inhibits food associated Bacillus cereus in rice. Food Chemistry. 2020; 339 ():127902.
Chicago/Turabian StyleVivek K. Bajpai; Inwha Park; Imran Khan; Fanar Hamad Alshammari; Pradeep Kumar; Lei Chen; MinKyun Na; Yun Suk Huh; Young-Kyu Han; Shruti Shukla. 2020. "(−)-Tetrahydroberberrubine∙acetate accelerates antioxidant potential and inhibits food associated Bacillus cereus in rice." Food Chemistry 339, no. : 127902.
Agriculture is the source of food for both humans and animals. With the growing population demands, agricultural production needs to be scaled up where nanotechnology can play a significant role. The use of nanotechnology in agriculture can manage plant disease and growth for better and quality output. Therefore, this review focuses on the use of various nanoparticles for detection of nutrients and contaminants, nanosensors for monitoring the environmental stresses and crop conditions as well as the use of nanotechnology for plant pathogen detection and crop protection. In addition, the delivery of plant growth regulators and agrichemicals like nanopesticides and nanofertilizers to the plants along with the delivery of DNA for targeted genetic engineering and production of genetically modified (GM) crops are discussed briefly. Further, the future concerns regarding the use of nanoparticles and their possible toxicity, impact on the agriculture and ecosystem needs to be assessed along with the assessment of the nanoparticles and GM crops on the environment and human health.
Madhu Kamle; Dipendra Kumar Mahato; Sheetal Devi; Ramendra Soni; Vijay Tripathi; Awdhesh Kumar Mishra; Pradeep Kumar. Nanotechnological interventions for plant health improvement and sustainable agriculture. 3 Biotech 2020, 10, 1 -11.
AMA StyleMadhu Kamle, Dipendra Kumar Mahato, Sheetal Devi, Ramendra Soni, Vijay Tripathi, Awdhesh Kumar Mishra, Pradeep Kumar. Nanotechnological interventions for plant health improvement and sustainable agriculture. 3 Biotech. 2020; 10 (4):1-11.
Chicago/Turabian StyleMadhu Kamle; Dipendra Kumar Mahato; Sheetal Devi; Ramendra Soni; Vijay Tripathi; Awdhesh Kumar Mishra; Pradeep Kumar. 2020. "Nanotechnological interventions for plant health improvement and sustainable agriculture." 3 Biotech 10, no. 4: 1-11.
Citrus is a genus belonging to the Rutaceae family and includes important crops like orange, lemons, pummelos, grapefruits, limes, etc. Citrus essential oils (CEOs) consist of some major biologically active compounds like α-/β-pinene, sabinene, β-myrcene, d-limonene, linalool, α-humulene, and α-terpineol belonging to the monoterpenes, monoterpene aldehyde/alcohol, and sesquiterpenes group, respectively. These compounds possess several health beneficial properties like antioxidant, anti-inflammatory, anticancer, etc., in addition to antimicrobial properties, which have immense potential for food applications. Therefore, this review focused on the extraction, purification, and detection methods of CEOs along with their applications for food safety, packaging, and preservation. Further, the concerns of optimum dose and safe limits, their interaction effects with various food matrices and packaging materials, and possible allergic reactions associated with the use of CEOs in food applications were briefly discussed, which needs to be addressed in future research along with efficient, affordable, and “green” extraction methods to ensure CEOs as an ecofriendly, cost-effective, and natural alternative to synthetic chemical preservatives.
Himashree Bora; Madhu Kamle; Dipendra Kumar Mahato; Pragya Tiwari; Pradeep Kumar. Citrus Essential Oils (CEOs) and Their Applications in Food: An Overview. Plants 2020, 9, 357 .
AMA StyleHimashree Bora, Madhu Kamle, Dipendra Kumar Mahato, Pragya Tiwari, Pradeep Kumar. Citrus Essential Oils (CEOs) and Their Applications in Food: An Overview. Plants. 2020; 9 (3):357.
Chicago/Turabian StyleHimashree Bora; Madhu Kamle; Dipendra Kumar Mahato; Pragya Tiwari; Pradeep Kumar. 2020. "Citrus Essential Oils (CEOs) and Their Applications in Food: An Overview." Plants 9, no. 3: 357.
Cancer is the second leading cause of death worldwide. The main modality to fight against cancer is surgery, radiotherapy, and chemotherapy, and more recently targeted therapy, gene therapy and immunotherapy, which play important roles in treating cancer patients. In the last decades, chemotherapy has been well developed. Nonetheless, administration of the drug is not always successful, as limited drug dosage can reach the tumor cells.. In this context, the possibility to use an encapsulated anti-cancer drug may potentially solve the problem. Liposomal cytarabine is a formulation with pronounced effectiveness in lymphomatous meningitis and reduced cardiotoxicity if compared to liposomal anthracyclines. Thus, the future liposomal cytarabine use could be extended to other diseases given its reduction in cytotoxic side effects compared to the free formulation. This review summarizes the chemistry and biology of liposomal cytarabine, with exploration of its clinical implications.
Bahare Salehi; Zeliha Selamoglu; Ksenija S. Mileski; Raffaele Pezzani; Marco Redaelli; William C. Cho; Farzad Kobarfard; Sadegh Rajabi; Miquel Martorell; Pradeep Kumar; Natália Martins; Tuhin Subhra Santra; Javad Sharifi-Rad. Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine. Biomolecules 2019, 9, 773 .
AMA StyleBahare Salehi, Zeliha Selamoglu, Ksenija S. Mileski, Raffaele Pezzani, Marco Redaelli, William C. Cho, Farzad Kobarfard, Sadegh Rajabi, Miquel Martorell, Pradeep Kumar, Natália Martins, Tuhin Subhra Santra, Javad Sharifi-Rad. Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine. Biomolecules. 2019; 9 (12):773.
Chicago/Turabian StyleBahare Salehi; Zeliha Selamoglu; Ksenija S. Mileski; Raffaele Pezzani; Marco Redaelli; William C. Cho; Farzad Kobarfard; Sadegh Rajabi; Miquel Martorell; Pradeep Kumar; Natália Martins; Tuhin Subhra Santra; Javad Sharifi-Rad. 2019. "Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine." Biomolecules 9, no. 12: 773.
In the last few decades, nanotechnology has come to the fore as a crucial and significant domain in the scientific realm owing to its multidisciplinary nature. The enhanced properties of materials in the nanoscale make them a viable option for different applications in different fields. The conventional method viz. the physical and chemical methods of nanoparticle production, however, pose hazardous risks to the environment. To redress these concerns, researchers have diverted their focus towards the more favourable green method of synthesis which is free from any toxic precursor or strenuous process conditions making it an economical and nature-friendly method. Nanoparticles showed a wide range of application in environmental biotechnology like reduction of pollution, water treatment, remediation, dye degradation and water purification development. This review focuses on the various biogenic precursors for fabrication of nanoparticles and also emphasizes their potential applications in environmental remediation.
Anupritee Das; Madhu Kamle; Ajay Bharti; Pradeep Kumar. Nanotechnology and it’s applications in environmental remediation: an overview. Vegetos 2019, 32, 227 -237.
AMA StyleAnupritee Das, Madhu Kamle, Ajay Bharti, Pradeep Kumar. Nanotechnology and it’s applications in environmental remediation: an overview. Vegetos. 2019; 32 (3):227-237.
Chicago/Turabian StyleAnupritee Das; Madhu Kamle; Ajay Bharti; Pradeep Kumar. 2019. "Nanotechnology and it’s applications in environmental remediation: an overview." Vegetos 32, no. 3: 227-237.
The fumonisins producing fungi, Fusarium spp., are ubiquitous in nature and contaminate several food matrices that pose detrimental health hazards on humans as well as on animals. This has necessitated profound research for the control and management of the toxins to guarantee better health of consumers. This review highlights the chemistry and biosynthesis process of the fumonisins, their occurrence, effect on agriculture and food, along with their associated health issues. In addition, the focus has been put on the detection and management of fumonisins to ensure safe and healthy food. The main focus of the review is to provide insights to the readers regarding their health-associated food consumption and possible outbreaks. Furthermore, the consumers’ knowledge and an attempt will ensure food safety and security and the farmers’ knowledge for healthy agricultural practices, processing, and management, important to reduce the mycotoxin outbreaks due to fumonisins.
Madhu Kamle; Dipendra K. Mahato; Sheetal Devi; Kyung Eun Lee; Sang G. Kang; Pradeep Kumar. Fumonisins: Impact on Agriculture, Food, and Human Health and their Management Strategies. Toxins 2019, 11, 328 .
AMA StyleMadhu Kamle, Dipendra K. Mahato, Sheetal Devi, Kyung Eun Lee, Sang G. Kang, Pradeep Kumar. Fumonisins: Impact on Agriculture, Food, and Human Health and their Management Strategies. Toxins. 2019; 11 (6):328.
Chicago/Turabian StyleMadhu Kamle; Dipendra K. Mahato; Sheetal Devi; Kyung Eun Lee; Sang G. Kang; Pradeep Kumar. 2019. "Fumonisins: Impact on Agriculture, Food, and Human Health and their Management Strategies." Toxins 11, no. 6: 328.
The genus Litsea is predominant in tropical and subtropical regions of India, China, Taiwan, and Japan. The plant possesses medicinal properties and has been traditionally used for curing various gastro-intestinal ailments (e.g., diarrhea, stomachache, indigestion, and gastroenteritis) along with diabetes, edema, cold, arthritis, asthma, and traumatic injury. Besides its medicinal properties, Litsea is known for its essential oil, which has protective action against several bacteria, possesses antioxidant and antiparasitic properties, exerts acute and genetic toxicity as well as cytotoxicity, and can even prevent several cancers. Here we summarize the ethnopharmacological properties, essentials oil, medicinal uses, and health benefits of an indigenous plant of northeast India, emphasizing the profound research to uplift the core and immense potential present in the conventional medicine of the country. This review is intended to provide insights into the gaps in our knowledge that need immediate focus on in-situ conservation strategies of Litsea due to its non-domesticated and dioecious nature, which may be the most viable approach and intense research for the long-term benefits of society and local peoples.
Madhu Kamle; Dipendra K. Mahato; Kyung Eun Lee; Vivek K. Bajpai; Padam Raj Gajurel; Kang Sang Gu; Pradeep Kumar. Ethnopharmacological Properties and Medicinal Uses of Litsea cubeba. Plants 2019, 8, 150 .
AMA StyleMadhu Kamle, Dipendra K. Mahato, Kyung Eun Lee, Vivek K. Bajpai, Padam Raj Gajurel, Kang Sang Gu, Pradeep Kumar. Ethnopharmacological Properties and Medicinal Uses of Litsea cubeba. Plants. 2019; 8 (6):150.
Chicago/Turabian StyleMadhu Kamle; Dipendra K. Mahato; Kyung Eun Lee; Vivek K. Bajpai; Padam Raj Gajurel; Kang Sang Gu; Pradeep Kumar. 2019. "Ethnopharmacological Properties and Medicinal Uses of Litsea cubeba." Plants 8, no. 6: 150.
Tomato and its derived products have a very interesting nutritional value in addition to prominent antioxidant, anti-inflammatory, and anticancer activities. Tomatoes are generally quite safe to eat. However, overall consumption varies from individual to individual. Indeed, either beneficial or harmful effects of plants or their derived products are closely related to quality, including the presence of biologically active compounds. On the other hand, the synthesis and accumulation of these bioactive molecules depends on many other factors, such as environmental conditions. In this sense, this review briefly highlights the relationship between the chemistry of tomato and its derived products and their beneficial or harmful effects on human health, such as gastroesophageal reflux disease or heartburn, allergies, kidney and cardiovascular disorders, prostate cancer, irritable bowel syndrome, lycopenodermia, body aches, arthritis, and urinary problems.
Bahare Salehi; Razieh Sharifi-Rad; Farukh Sharopov; Jacek Namiesnik; Amir Roointan; Madhu Kamle; Pradeep Kumar; Natália Martins; Javad Sharifi-Rad. Beneficial effects and potential risks of tomato consumption for human health: An overview. Nutrition 2019, 62, 201 -208.
AMA StyleBahare Salehi, Razieh Sharifi-Rad, Farukh Sharopov, Jacek Namiesnik, Amir Roointan, Madhu Kamle, Pradeep Kumar, Natália Martins, Javad Sharifi-Rad. Beneficial effects and potential risks of tomato consumption for human health: An overview. Nutrition. 2019; 62 ():201-208.
Chicago/Turabian StyleBahare Salehi; Razieh Sharifi-Rad; Farukh Sharopov; Jacek Namiesnik; Amir Roointan; Madhu Kamle; Pradeep Kumar; Natália Martins; Javad Sharifi-Rad. 2019. "Beneficial effects and potential risks of tomato consumption for human health: An overview." Nutrition 62, no. : 201-208.
The bacterial biota in larvae of Capnodis tenebrionis, a serious pest of cultivated stone-fruit trees in the West Palearctic, was revealed for the first time using the MiSeq platform. The core bacterial community remained the same in neonates whether upon hatching or grown on peach plants or an artificial diet, suggesting that C. tenebrionis larvae acquire much of their bacterial biome from the parent adult. Reads affiliated with class levels Gammaproteobacteria and Alphaproteobacteria (phylum Proteobacteria ca. 86%), and Actinobacteria (ca. 14%) were highly abundant. Most diverse reads belong to the families Xanthomonadaceae (50%), Methylobacteriaceae (20%), Hyphomicrobiaceae (9%), Micrococcaceae (7%) and Geodermatophilaceae (4.5%). About two-thirds of the reads are affiliated with the genera Lysobacter, Microvirga, Methylobacterium, and Arthrobacter, which encompass species displaying cellulolytic and lipolytic activities. This study provides a foundation for future studies to elucidate the roles of bacterial biota in C. tenebrionis.
Hana Barak; Pradeep Kumar; Arieh Zaritsky; Zvi Mendel; Dana Ment; Ariel Kushmaro; Eitan Ben-Dov. Diversity of Bacterial Biota in Capnodis tenebrionis (Coleoptera: Buprestidae) Larvae. Pathogens 2019, 8, 4 .
AMA StyleHana Barak, Pradeep Kumar, Arieh Zaritsky, Zvi Mendel, Dana Ment, Ariel Kushmaro, Eitan Ben-Dov. Diversity of Bacterial Biota in Capnodis tenebrionis (Coleoptera: Buprestidae) Larvae. Pathogens. 2019; 8 (1):4.
Chicago/Turabian StyleHana Barak; Pradeep Kumar; Arieh Zaritsky; Zvi Mendel; Dana Ment; Ariel Kushmaro; Eitan Ben-Dov. 2019. "Diversity of Bacterial Biota in Capnodis tenebrionis (Coleoptera: Buprestidae) Larvae." Pathogens 8, no. 1: 4.
The term “antioxidant” is one of the most confusing definitions in biological/medical sciences. In chemistry, “antioxidant” is simply conceived “a compound that removes reactive species, mainly those oxygen-derived”, while in a cell context, the conceptual definition of an antioxidant is poorly understood. Indeed, non-clinically recommended antioxidants are often consumed in large amounts by the global population, based on the belief that cancer, inflammation and degenerative diseases are triggered by high oxygen levels (or reactive oxygen species) and that through blocking reactive species production, organic unbalances/disorders can be prevented and/or even treated. The popularity of these chemicals arises in part from the widespread public mistrust of allopathic medicine. In fact, reactive oxygen species play a dual role in dealing with different disorders, since they may contribute to disease onset and/or progression but may also play a key role in disease prevention. Further, the ability of the most commonly used supplements, such as vitamins C, E, selenium, and herbal supplements to decrease pathologic reactive oxygen species is not clearly established. Hence, the present review aims to provide a nuanced understanding of where current knowledge is and where it should go.
Bahare Salehi; Miquel Martorell; Jack Arbiser; Antoni Sureda; Natália Martins; Pawan Maurya; Mehdi Sharifi-Rad; Pradeep Kumar; Javad Sharifi-Rad. Antioxidants: Positive or Negative Actors? Biomolecules 2018, 8, 124 .
AMA StyleBahare Salehi, Miquel Martorell, Jack Arbiser, Antoni Sureda, Natália Martins, Pawan Maurya, Mehdi Sharifi-Rad, Pradeep Kumar, Javad Sharifi-Rad. Antioxidants: Positive or Negative Actors? Biomolecules. 2018; 8 (4):124.
Chicago/Turabian StyleBahare Salehi; Miquel Martorell; Jack Arbiser; Antoni Sureda; Natália Martins; Pawan Maurya; Mehdi Sharifi-Rad; Pradeep Kumar; Javad Sharifi-Rad. 2018. "Antioxidants: Positive or Negative Actors?" Biomolecules 8, no. 4: 124.