Automated retinal vessel segmentation technology has become an important tool for disease screening and diagnosis in clinical medicine. However, most of the available methods of retinal vessel segmentation still have problems such as poor accuracy and low generalization ability. This is because the symmetrical and asymmetrical patterns between blood vessels are complicated, and the contrast between the vessel and the background is relatively low due to illumination and pathology. Robust vessel segmentation of the retinal image is essential for improving the diagnosis of diseases such as vein occlusions and diabetic retinopathy. Automated retinal vein segmentation remains a challenging task. In this paper, we proposed an automatic retinal vessel segmentation framework using deep fully convolutional neural networks (FCN), which integrate novel methods of data preprocessing, data augmentation, and full convolutional neural networks. It is an end-to-end framework that automatically and efficiently performs retinal vessel segmentation. The framework was evaluated on three publicly available standard datasets, achieving F1 score of 0.8321, 0.8531, and 0.8243, an average accuracy of 0.9706, 0.9777, and 0.9773, and average area under the Receiver Operating Characteristic (ROC) curve of 0.9880, 0.9923 and 0.9917 on the DRIVE, STARE, and CHASE_DB1 datasets, respectively. The experimental results show that our proposed framework achieves state-of-the-art vessel segmentation performance in all three benchmark tests.

The incidence of skin cancer around the world is increasing year by year. However, early diagnosis and treatment can greatly improve the survival rate of patients. Skin lesion boundary segmentation is essential to accurately locate lesion areas in dermatoscopic images. It is true that accurate segmentation of skin lesions is still challenging dues to problems such as blurred borders, which requires an accurate and automatic skin lesion segmentation method. In this paper, we propose an end-to-end framework which can perform skin lesion segmentation automatically and efficiently, called the CSARM-CNN (Channel & Spatial Attention Residual Module) model. Each CSARM block of the model combines channel attention and spatial attention to form a new attention module to enhance segmentation results. The multi-scale input images are obtained by the spatial pyramid pooling. Finally, a weighted cross-entropy loss function is used at each side of the output layer to sum the total loss of the model. We evaluated in two published standard datasets, ISIC 2017 and PH2, and achieved competitive results in terms of specificity and accuracy, with 99.03% and 99.45% specificity, 94.96% and 95.23% accuracy, respectively.

Automatic classification of H&E breast cancer histopathology images is a challenging task. Computer-aided diagnostic systems help reduce costs and increase the efficiency of the process. Although the existing research on breast cancer histopathology image classification is higher than 90% accurate in the binary classifications (non-carcinoma/carcinoma), the classification accuracy of four classifications (normal, benign, in situ, invasive) is less than 80%. This paper proposes a framework for the classification of H&E stained breast cancer histopathological images, which includes two methods based on convolutional neural network. The first method is based on the convolutional neural network structure of the SE-ResNet module, and the second method is based on the transfer learning hybrid model structure, which achieves the accuracy of 80.33% and 86.11% respectively. Compared with the state-of-the-art method, the accuracy is improved by 2.56% and 8.33% respectively. The proposed framework achieves 91.67% accuracy in binary classification and is competitive with state-of-the-art methods.