Background: NLR is a systemic inflammatory marker that have been associated with overall survival in patients with some rapidly progressive disease. There are few data about the diagnostic and predictive value of NLR in autoimmune diseases, and it has not been described in anti-MDA5 positive DM. We try to correlate neutrophil-to-lymphocyte ratio (NLR) with fatality from dermatomyositis in anti-MDA5 positive patients. Method: A retrospective study in which 195 patients were enrolled was conducted. Clinical and laboratory information was collated and ratios of neutrophil to lymphocyte counts (NLR) calculated. The primary end point was all-cause death. Result: Of the 195 patients studied, all had interstitial lung disease, including 140 survivors and 55 non-survivors. An optimal NLR cut-off value of 4.86 for mortality prediction was identified. The NLR of non-survivors was significantly higher than that of survivors (p < 0.001). Plasma levels of lactate dehydrogenase (LDH) and C-reactive protein were significantly increased when NLR was greater than 4.86. Results of multivariate analysis established that NLR > 4.86 was an independent predictor of mortality (HR: 2.52; 95%CI: 1.33–4.78; p = 0.005). Abstinence from smoking (HR: 2.66; 95%CI: 1.33–4.78; p = 0.003), emergence of rapidly progressive interstitial lung disease (RPILD; HR: 4.38; 95%CI: 2.37–8.08; p < 0.001), low plasma LDH (HR: 3.82; 95%CI: 2.06–7.11; p < 0.001) and presentation with dyspnea (HR: 2.17; 95%CI: 1.22–3.86; p = 0.009) were all protective factors predictive of survival. Conclusion: NLR is a cost-effective and widely accessible biomarker with utility for risk stratification in patients with anti-MDA5 + dermatomyositis.

BACKGROUND: China has the world’s largest elderly population, as well as the largest population of disabled elderly. Existing literature shows that there have been increased efforts to develop intelligent robots to address the shortage of caregivers for the elderly. However, there has been little research on elders’ acceptance of care from intelligent robots. AIMS: The purpose of this study was to examine the acceptance of intelligent robots among disabled elderly in need of long-term care. METHODS: We used structured questionnaires and interview methods during a social survey. In total, 3060 questionnaires and 50 interviews were collected. RESULTS: An overwhelming majority of the 3060 participants (79.39%) indicated that they would reject robot care. DISCUSSION: Future research should consider the background of the interviewees and the influence of the economy and social development across different regions, in order to distinguish the impact of each type of basic information on the acceptance of intelligent machines by the elderly. CONCLUSIONS: Most elderly adults were reluctant to allow robots to provide services that involved physical contact. Therefore, the development and design of robots should consider elderly individuals’ attitudes toward non-human services, in addition to broadening the scope of activities that intelligent robots could cover, and providing intelligent tools and products that the elderly would be more likely to gradually accept.

Background China has the world's largest elderly population, as well as the largest population of disabled elderly. Existing literature shows that there have been increased efforts to develop intelligent robots to address the shortage of caregivers for the elderly. However, there has been little research on elders’ acceptance of care from intelligent robots. Aims The purpose of this study was to examine the acceptance of intelligent robots among disabled elderly in need of long-term care. Methods We used structured questionnaire and interview methods during a social survey. In total, 3060 questionnaires and 50 interviews were collected. Results An overwhelming majority of the 3060 participants (79.39%) indicated that they would reject robot care. Discussion In further research, should consider more about the background of interviewees, the influence of the economy and social development across different regions, and distinguish the impact of each type of basic information on the acceptance of intelligent machines by the elderly. Conclusions Most elderly adults were reluctant to allow robots to provide services that involved physical contact. Therefore, the development and design of robots should consider elderly individuals’ attitudes toward non-human services, in addition to broadening the scope of activities that intelligent robots could cover, and providing intelligent tools and products that the elderly would be more likely to gradually accept.

Hina has the world's largest elderly population, as well as the largest population of disabled elderly. Existing literature shows that there have been increased efforts to develop intelligent robots to address the shortage of care givers for the elderly.