This review article surveys recent experimental and theoretical advances in the gas-phase ion chemistry of the noble gases. Covered issues include the interaction of the noble gases with metal and non-metal cations, the conceivable existence of covalent noble-gas anions, the occurrence of ion–molecule reactions involving singly-charged xenon cations and the occurrence of bond-forming reactions involving doubly-charged cations. Research themes are also highlighted, which are expected to attract further interest in the nearfuture.

Cationic species with noble gas (Ng)-hydrogen bonds play a major role in the gas-phase ion chemistry of the group 18 elements. These species first emerged more than 90 years ago, when the simplest HeH⁺ and HeH${}_2^{+}$ were detected from ionized He/H₂ mixtures. Over the years, the family has considerably expanded and currently includes various bonding motifs that are investigated with intense experimental and theoretical interest. Quite recently, the results of these studies acquired new and fascinating implications. The diatomic ArH⁺ and HeH⁺ were, in fact, detected in various galactic and extragalactic regions, and this stimulates intriguing questions concerning the actual role in the outer space of the Ng-H cations observed in the laboratory. The aim of this review is to briefly summarize the most relevant information currently available on the structure, stability, and routes of formation of these fascinating systems.