An efficient, green, and sustainable synthesis of new hybrid molecules containing flavanone with triazole by merging the Michael addition and Click reaction using a copper oxide/reduced graphene oxide nanocomposite in one pot is reported. The catalyst can easily be recycled and reused in seven consecutive runs without compromising the product yields. Other notable advantages include using water as a reaction medium and obtaining good to excellent yields, low catalyst loading, high atom efficiency, high substrate variation, and good results in the gram scale reaction.

We report a sustainable and metal free carbocatalyst, graphite oxide, for the synthesis of 1,5-benzodiazepines under room temperature and solvent free heating conditions.

An efficient, highly product selective, eco-friendly, one-pot multicomponent synthesis of dihydropyrimidine derivatives via Biginelli reaction has been described. The reaction was developed by greener nanoparticle-catalyzed organic synthesis enhancement (NOSE) chemistry and solvent free reaction condition (SFRC) approaches, which helped us in making the procedure greener. The reaction went smoothly with a diverse range of aromatic, aliphatic, hetero-aromatic aldehydes, different amine sources, as well as various β-dicarbonyl compounds, showing the flexibility of this methodology. Magnetically separable nano-Fe₃O₄@SiO₂@SO₃H, which acts as a potent solid acid catalyst, was characterized by FT-IR, SEM, EDX and TEM, VSM, and TGA analyses. The catalyst was recycled from the reaction mixture easily by an external magnet and reused in five more consecutive runs without much decrease in catalytic activity. Its catalytic efficiency was compared to other nano and bulk solid acid catalyst in order to ascertain the best combination for the conversion. GRAPHICAL ABSTRACT