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SERENA MANCARELLA
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Representative Publications
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Journal Article
Laia CajaFDFrancesco Dituri
Francesco DituriSMSERENA MANCARELLA
SERENA MANCARELLADCDaniel Caballero-Diaz
Daniel Caballero-DiazAMAristidis Moustakas
Aristidis Moustakas
Isabel Fabregat +1
Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic response and for the activation of the cancer stroma. Strong evidence suggests that a strong cross-talk exists among TGF-β and the tissue extracellular matrix components. TGF-β is stored in the matrix as part of a large latent complex bound to the latent TGF-β binding protein (LTBP) and matrix binding of latent TGF-β complexes, which is required for an adequate TGF-β function. Once TGF-β is activated, it regulates extracellular matrix remodelling and promotes a fibroblast to myofibroblast transition, which is essential in fibrotic processes. This cytokine also acts on other cell types present in the fibrotic and tumour microenvironment, such as epithelial, endothelial cells or macrophages and it contributes to the cancer-associated fibroblast (CAF) phenotype. Furthermore, TGF-β exerts anti-tumour activity by inhibiting the host tumour immunosurveillance. Aim of this review is to update how TGF-β and the tissue microenvironment cooperate to promote the pleiotropic actions that regulate cell responses of different cell types, essential for the development of fibrosis and tumour progression. We discuss recent evidences suggesting the use of TGF-β chemical inhibitors as a new line of defence against fibrotic disorders or cancer.
Journal Article
FDFrancesco Dituri
Francesco DituriCCCarla Cossu
Carla CossuSMSERENA MANCARELLA
SERENA MANCARELLA
Gianluigi GiannelliThe Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP) pathways intersect at multiple signaling hubs and cooperatively or counteractively participate to bring about cellular processes which are critical not only for tissue morphogenesis and organogenesis during development, but also for adult tissue homeostasis. The proper functioning of the TGFβ/BMP pathway depends on its communication with other signaling pathways and any deregulation leads to developmental defects or diseases, including fibrosis and cancer. In this review we explore the cellular and physio-pathological contexts in which the synergism or antagonism between the TGFβ and BMP pathways are crucial determinants for the normal developmental processes, as well as the progression of fibrosis and malignancies.
1 May 2014 in Advances in Colloid and Interface Science
Journal Article
Loretta L. del MercatoMFMarzia Maria Ferraro
Marzia Maria Ferraro
Francesca BaldassarreSMSERENA MANCARELLA
SERENA MANCARELLAVGValentina Greco
Valentina Greco
Stefano Leporatti +1
27 October 2016 in Hepatology
Journal Article
Amalia AzzaritiSMSERENA MANCARELLA
SERENA MANCARELLALPLetizia Porcelli
Letizia Porcelli
AQAnna Elisa Quatrale
Anna Elisa Quatrale
ACAlessandra Caligiuri
Alessandra Caligiuri
Gianluigi Giannelli +2
17 June 2015 in Macromolecular Bioscience
Journal Article
SMSERENA MANCARELLA
SERENA MANCARELLAVGValentina Greco
Valentina GrecoFrancesca Baldassarre
Daniele Vergara
MICHELE MAFFIAStefano Leporatti23 March 2019 in Liver International
Journal Article
Laura FouassierMMMarco Marzioni
Marco MarzioniMAMarta B. Afonso
Marta B. AfonsoSDSteven Dooley
Steven Dooley
Kevin Gaston
Cedric Coulouarn +7
About Me
Fouassier, L.; Marzioni, M.; Afonso, M.B.; Dooley, S.; Gaston, K.; Giannelli, G.; Rodrigues, C.M.P.; Lozano, E.; Mancarella, S.; Segatto, O.; et al. Signalling networks in cholangiocarcinoma: Molecular pathogenesis, targeted therapies and drug resistance. Liver Int. 2019, 39, 43–62.
Mancarella, S.; Serino, G.; Dituri, F.; Cigliano, A.; Ribback, S.; Wang, J.; Chen, X.; Calvisi, D.F.; Giannelli, G. Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis. Cell Death Differ. 2020.
Mancarella, S.; Serino, G.; Gigante, I.; Cigliano, A.; Ribback, S.; Sanese, P.; Grossi, V.; Simone, C.; Armentano, R.; Evert, M.; et al. CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype. J. Exp. Clin. Cancer Res. 2022, 41, 65.
Azzariti, A.; Mancarella, S.; Porcelli, L.; Quatrale, A.E.; Caligiuri, A.; Lupo, L.; Dituri, F.; Giannelli, G. Hepatic stellate cells induce hepatocellular carcinoma cell resistance to sorafenib through the laminin-332/α3 integrin axis recovery of focal adhesion kinase ubiquitination. Hepatology 2016, 64, 2103–2117.
Mancarella, S.; Serino, G.; Dituri, F.; Cigliano, A.; Ribback, S.; Wang, J.; Chen, X.; Calvisi, D.F.; Giannelli, G.; Agarwal, R.; et al. Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression. Cancers (Basel). 2019, 39, 43–62.