Daniela Chagas-Paula

Dr. Daniela Chagas-Paula

orcid

Research Focus & Metrics

Academic Career Length

17Years (2010-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 February 2012 in Chemistry & Biodiversity
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DCDaniela Chagas-Paula
Daniela Chagas-Paula
RORejane B. Oliveira
Rejane B. Oliveira
BRBruno Alves Rocha
Bruno Alves Rocha
FCFernando Da Costa
Fernando Da Costa

1 June 2011 in Journal of Ethnopharmacology
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Journal Article
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DCDaniela Chagas-Paula
Daniela Chagas-Paula
RORejane Barbosa de Oliveira
Rejane Barbosa de Oliveira
VSVanessa Cristina da Silva
Vanessa Cristina da Silva
LGLeonardo Gobbo-Neto
Leonardo Gobbo-Neto
TGThaís Helena Gasparoto
Thaís Helena Gasparoto
FCFernando Da Costa
Fernando Da Costa

8 July 2015 in Metabolites
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Journal Article
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DCDaniela Chagas-Paula
Daniela Chagas-Paula
TZTong Zhang
Tong Zhang
FCFernando Da Costa
Fernando Da Costa
Ru Angelie Edrada-EbelRu Angelie Edrada-Ebel
Ru Angelie Edrada-Ebel
The application of metabolomics in phytochemical analysis is an innovative strategy for targeting active compounds from a complex plant extract. Species of the Asteraceae family are well-known to exhibit potent anti-inflammatory (AI) activity. Dual inhibition of the enzymes COX-1 and 5-LOX is essential for the treatment of several inflammatory diseases, but there is not much investigation reported in the literature for natural products. In this study, 57 leaf extracts (EtOH-H2O 7:3, v/v) from different genera and species of the Asteraceae family were tested against COX-1 and 5-LOX while HPLC-ESI-HRMS analysis of the extracts indicated high diversity in their chemical compositions. Using O2PLS-DA (R2 > 0.92; VIP > 1 and positive Y-correlation values), dual inhibition potential of low-abundance metabolites was determined. The O2PLS-DA results exhibited good validation values (cross-validation = Q2 > 0.7 and external validation = P2 > 0.6) with 0% of false positive predictions. The metabolomic approach determined biomarkers for the required biological activity and detected active compounds in the extracts displaying unique mechanisms of action. In addition, the PCA data also gave insights on the chemotaxonomy of the family Asteraceae across its diverse range of genera and tribes.

1 February 2016 in Mini-Reviews in Medicinal Chemistry
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PCPatrícia Lunardelli Negreiros de Carvalho
Patrícia Lunardelli Negreiros de Carvalho
ESEliane Silva
Eliane Silva
DCDaniela Chagas-Paula
Daniela Chagas-Paula
JLJaine H. H. Luiz
Jaine H. H. Luiz
MIMasaharu Ikegaki
Masaharu Ikegaki
In the natural products research, a valuable approach is the prospection of uncommon sources and unexplored habitat. Special attention has been given to endophytic fungi because of their ability to produce new and interesting secondary metabolites, which have several biological applications. The endophytes establish exclusive symbiotic relationships with plants and the metabolic interactions may support the synthesis of some similar valuables compounds. Among secondary metabolites, phenol-derived structures are responsible for several bioactivities such as antioxidant, cytotoxic, antimicrobial, among others. Phenolic compounds might be biosynthesized from the shikimate pathway. Although shikimic acid is a common precursor in plants, it is described as rare in microorganisms. To the best of our knowledge, this is the first review about phenolic compounds produced by endophytic fungi and a comparison has been made with those produced by the plant host. This review covers 124 phenolic secondary metabolites produced by endophytic fungi. Considering the data analyzed by us, only seven of such compounds were isolated from fungi and from their hosts. These observations claim for more attention to phenolic compounds produced by endophytic fungi with a view to understand the real importance of these compounds to endophytes survival.

1 January 2017 in Oxidative Medicine and Cellular Longevity
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JBJoão Luiz Baldim
João Luiz Baldim
BABianca Gonçalves Vasconcelos De Alcântara
Bianca Gonçalves Vasconcelos De Alcântara
ODOlívia Da Silva Domingos
Olívia Da Silva Domingos
MSMarisi Soares
Marisi Soares
ICIvo Santana Caldas
Ivo Santana Caldas
DCDaniela Chagas-Paula
Daniela Chagas-Paula
Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. The chemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development of drug resistance. Thus, a series of 40 flavonoids were investigated with the purpose of correlating these properties via structure and activity analyses based on integrated networks and QSAR models. The classical groups for the antioxidant activity of flavonoids were combined in order to explain the influence of antioxidant and prooxidant activities on the antiparasitic properties. These analyses become useful for the development of efficient treatments for leishmaniasis and trypanosomiasis. Finally, the dual activity of flavonoids presenting both anti‐ and prooxidant activities revealed that the existence of a balance between these two features could be important to the development of adequate therapeutic strategies.

1 June 2020 in Journal of Ethnopharmacology
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AKAlbert Katchborian-Neto
Albert Katchborian-Neto
WSWanderleya T. Santos
Wanderleya T. Santos
KNKaren J. Nicácio
Karen J. Nicácio
JCJosé O.A. Corrêa
José O.A. Corrêa
MMMichael Murgu
Michael Murgu
APAna C.C. Paula
Ana C.C. Paula