The applications of α-linolenic acid (ALA) in the food industry are restricted due to its poor water solubility and antioxidant stability. This study concentrates on developing an ALA-loaded microemulsion (ALA-ME) to enhance its solubility and antioxidant capacity. The formulation of the microemulsion was investigated based on pseudoternary phase diagrams. The ALA-ME was characterized by using electrical conductivity, viscosity and transmission electron microscopy (TEM). The microstructure of the ALA-ME was probed using nuclear magnetic resonance (¹H-NMR). The results proved that ALA-ME consisted of spheroidal droplets with 20–40 nm diameter. A structural transformation from water in oil (W/O) to oil in water (O/W) occurred, as seen from the electrical conductivity determination. The ¹H-NMR results revealed a transition of the ALA position encapsulated from the core area of the microemulsion to the lipophilic layer of the surfactant. Furthermore, two microstructural models of ALA-ME were proposed. The antioxidant evaluation demonstrated that the ALA antioxidant capacity in microemulsions was enhanced to about 80% compared with that of ALA in oil solution.

Herein, the 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) acetonitrile solvate, a novel solid-state form of CL-20, was first discovered and characterized by various analytical techniques. The results of single-crystal X-ray diffraction (SCXRD) indicate that it is a channel-type solvate. Intermolecular interactions inside the crystal were investigated to elucidate the assembly behaviors with the assistance of the Hirshfeld surface analysis. The solvation profile and solubility data were determined to identify the thermodynamic stability of the acetonitrile solvate and form ε. The solution-mediated phase transformation (SMPT) from the acetonitrile solvate to form ε in acetonitrile–chloroform mixed solvents was online monitored by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy and in situ Raman spectroscopy. The results reveal that the nucleation and growth of the form ε is the rate-determining step. Moreover, the Johnson–Mehl–Avrami (JMA) model was employed to obtain deeper insights into the transformation kinetics. Furthermore, the effects of solvent composition, solid loading, and agitation rate were examined. This study provides an alternative approach for obtaining the desired form ε crystals and lays a foundation for the optimization of the crystallization process in the future.