Significance: Microfluidic organ-on-a-chip technology is poised to replace animal toxicity testing, but thus far has demonstrated few advantages over traditional methods. Here we demonstrate a sensor-integrated platform permitting real-time tracking of the dynamics of metabolic adaptation to mitochondrial dysfunction. Our approach permits detection of chemical toxicity before any effects on cell or tissue viability can be observed.

For biomedical and textile applications, the comfort of the user will be enhanced if the electronic circuits are not only flexible but also elastic. This letter reveals a simple moulded-interconnect-device technology for the construction of elastic point-to-point interconnections, based on 2-D spring-shaped metallic tracks, which are embedded in a highly elastic silicone film. Metal interconnections of 3-cm long were constructed with an initial resistance of about 3Omega , which did not significantly increase (<5%) when stretched. A stretchability above 100% in one direction has been demonstrated.

We present a flexible folded slot dipole implantable antenna operating in the Industrial, Scientific, and Medical (ISM) band (2.4-2.4835 GHz) for biomedical applications. To make the designed antenna suitable for implantation, it is embedded in biocompatible Polydimethylsiloxane (PDMS). The antenna was tested by immersing it in a phantom liquid, imitating the electrical properties of the human muscle tissue. A study of the sensitivity of the antenna performance as a function of the dielectric parameters of the environment in which it is immersed was performed. Simulations and measurements in planar and bent state demonstrate that the antenna covers the complete ISM band. In addition, Specific Absorption Rate (SAR) measurements indicate that the antenna meets the required safety regulations.