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Paeonia suffruticosa is an ornamental, edible, and medicinal plant. The ethanolic extracts of P. suffruticosa bud and flower were examined for their antioxidant, anti-photoaging, and phytochemical properties prior to chemometric analysis. The results showed that the bud ethanolic extract (BEE) and the flower (the early flowering stage) ethanolic extract (FEE) had better antioxidant activities, and significantly increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and reduced the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the skin tissues. In total, 68 compounds, including 20 flavonoids, 15 phenolic derivatives, 12 terpenoids, 9 fatty acids, and 12 others were identified or tentatively identified by ultra-fast liquid chromatography quadrupole time-of-flight mass spectrometry (UFLC-Q-TOF-MS). Gallic acid, 1,2,3,4,6-O-pentagalloyl glucose, paeoniflorin, and oxypaeoniflorin were predominant compounds in the extracts. Taken together, P. suffruticosa flowers are a candidate for functional material in food and health related industries, and their optimal time to harvest is before the early flowering stage.
Jingyu He; Yaqian Dong; Liu; Yiling Wan; Tanwei Gu; Xuefeng Zhou; He; Dong; Wan; Gu; Zhou; Xiaoyan Liu; Menghua Liu. Comparison of Chemical Compositions, Antioxidant, and Anti-Photoaging Activities of Paeonia suffruticosa Flowers at Different Flowering Stages. Antioxidants 2019, 8, 345 .
AMA StyleJingyu He, Yaqian Dong, Liu, Yiling Wan, Tanwei Gu, Xuefeng Zhou, He, Dong, Wan, Gu, Zhou, Xiaoyan Liu, Menghua Liu. Comparison of Chemical Compositions, Antioxidant, and Anti-Photoaging Activities of Paeonia suffruticosa Flowers at Different Flowering Stages. Antioxidants. 2019; 8 (9):345.
Chicago/Turabian StyleJingyu He; Yaqian Dong; Liu; Yiling Wan; Tanwei Gu; Xuefeng Zhou; He; Dong; Wan; Gu; Zhou; Xiaoyan Liu; Menghua Liu. 2019. "Comparison of Chemical Compositions, Antioxidant, and Anti-Photoaging Activities of Paeonia suffruticosa Flowers at Different Flowering Stages." Antioxidants 8, no. 9: 345.
Diabetic kidney disease (DKD) is the most serious microvascular complication during the development of diabetes with the characterizations of glomerular basement membrane thickening, mesangial expansion, and glomerular sclerosis, eventually leading to end-stage renal disease. This study aimed to investigate the melioration effect of Codonopisis tangshen Oliv. (COD) on the DKD model, which was established by unilateral nephrectomy (UN)-high fat diet feeding (HFD) combined with streptozotocin (STZ). After the DKD rats were oral treated with COD at a dose of 2.7 mg/kg for 4 consecutive weeks, the blood glucose, lipid metabolism, renal function, inflammatory mediators, and fibrosis-associated proteins were examined. In vivo, the COD administration obviously relieved the weight loss, water intake, and blood glucose; decreased the total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels; and improved the renal function by reducing the expression of serum creatinine, uric acid, and urinary protein compared with the model group. The levels of pro-inflammatory cytokines of tumor necrosis factor-α, interleukin-1β, and IL-6 were significantly inhibited by COD. Meanwhile, the deposition of collagen fiber was markedly increased, and the protein and mRNA expressions of transforming growth factor-β1 and α-smooth muscle actin were markedly elevated in DKD rats, but they were decreased to some extent after the COD treatment. In conclusion, COD exhibited a protective effect on the UN-HFD feeding combined with STZ-induced DKD model by improving the blood glucose and lipid metabolism, relieving the inflammatory response, and mitigating the renal fibrosis, which provided scientific evidence for its applications in clinic.
Xian-Yuan Lu; Feng-Hua Zhou; Ya-Qian Dong; Lin-Na Gong; Qing-Yun Li; Lan Tang; Zheng Cai; Jing-Yu He; Meng-Hua Liu. Codonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combined with Streptozotocin. Natural Products and Bioprospecting 2018, 8, 441 -451.
AMA StyleXian-Yuan Lu, Feng-Hua Zhou, Ya-Qian Dong, Lin-Na Gong, Qing-Yun Li, Lan Tang, Zheng Cai, Jing-Yu He, Meng-Hua Liu. Codonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combined with Streptozotocin. Natural Products and Bioprospecting. 2018; 8 (6):441-451.
Chicago/Turabian StyleXian-Yuan Lu; Feng-Hua Zhou; Ya-Qian Dong; Lin-Na Gong; Qing-Yun Li; Lan Tang; Zheng Cai; Jing-Yu He; Meng-Hua Liu. 2018. "Codonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combined with Streptozotocin." Natural Products and Bioprospecting 8, no. 6: 441-451.
Hedyotis diffusa is a folk herb that is used for treating inflammation-related diseases in Asia. Previous studies have found that iridoids in H. diffusa play an important role in its anti-inflammatory activity. This study aimed to investigate the anti-inflammatory effect and potential mechanism of five iridoids (asperuloside (ASP), asperulosidic acid (ASPA), desacetyl asperulosidic acid (DAA), scandoside methyl ester (SME), and E-6-O-p-coumaroyl scandoside methyl ester (CSME)) that are presented in H. diffusa using lipopolysaccharide (LPS)—induced RAW 264.7 cells. ASP and ASPA significantly decreased the production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in parallel with the inhibition of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-α, and IL-6 mRNA expression in LPS-induced RAW 264.7 cells. ASP treatment suppressed the phosphorylation of the inhibitors of nuclear factor-kappaB alpha (IκB-α), p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK). The inhibitory effect of ASPA was similar to that of ASP, except for p38 phosphorylation. In summary, the anti-inflammatory effects of ASP and ASPA are related to the inhibition of inflammatory cytokines and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways, which provides scientific evidence for the potential application of H. diffusa.
Jingyu He; Xianyuan Lu; Ting Wei; Yaqian Dong; Zheng Cai; Lan Tang; Menghua Liu. Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. International Journal of Molecular Sciences 2018, 19, 2027 .
AMA StyleJingyu He, Xianyuan Lu, Ting Wei, Yaqian Dong, Zheng Cai, Lan Tang, Menghua Liu. Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. International Journal of Molecular Sciences. 2018; 19 (7):2027.
Chicago/Turabian StyleJingyu He; Xianyuan Lu; Ting Wei; Yaqian Dong; Zheng Cai; Lan Tang; Menghua Liu. 2018. "Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages." International Journal of Molecular Sciences 19, no. 7: 2027.
The iridoids of Hedyotis diffusa Willd play an important role in the anti-inflammatory process, but the specific iridoid with anti-inflammatory effect and its mechanism has not be thoroughly studied. An iridoid compound named scandoside (SCA) was isolated from H. diffusa and its anti-inflammatory effect was investigated in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Its anti-inflammatory mechanism was confirmed by in intro experiments and molecular docking analyses. As results, SCA significantly decreased the productions of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and inhibited the levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-α and IL-6 messenger RNA (mRNA) expression in LPS-induced RAW 264.7 macrophages. SCA treatment suppressed the phosphorylation of inhibitor of nuclear transcription factor kappa-B alpaha (IκB-α), p38, extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). The docking data suggested that SCA had great binding abilities to COX-2, iNOS and IκB. Taken together, the results indicated that the anti-inflammatory effect of SCA is due to inhibition of pro-inflammatory cytokines and mediators via suppressing the nuclear transcription factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways, which provided useful information for its application and development.
Jingyu He; Jiafeng Li; Han Liu; Zichao Yang; Fenghua Zhou; Ting Wei; Yaqian Dong; Hongjiao Xue; Lan Tang; Menghua Liu. Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. International Journal of Molecular Sciences 2018, 19, 457 .
AMA StyleJingyu He, Jiafeng Li, Han Liu, Zichao Yang, Fenghua Zhou, Ting Wei, Yaqian Dong, Hongjiao Xue, Lan Tang, Menghua Liu. Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. International Journal of Molecular Sciences. 2018; 19 (2):457.
Chicago/Turabian StyleJingyu He; Jiafeng Li; Han Liu; Zichao Yang; Fenghua Zhou; Ting Wei; Yaqian Dong; Hongjiao Xue; Lan Tang; Menghua Liu. 2018. "Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages." International Journal of Molecular Sciences 19, no. 2: 457.
Jing-Yu He; Yuan-He Zhang; Na Ma; Xu-Lin Zhang; Meng-Hua Liu; Wei-Ming Fu. Comparative analysis of multiple ingredients in Rosa roxburghii and R . sterilis fruits and their antioxidant activities. Journal of Functional Foods 2016, 27, 29 -41.
AMA StyleJing-Yu He, Yuan-He Zhang, Na Ma, Xu-Lin Zhang, Meng-Hua Liu, Wei-Ming Fu. Comparative analysis of multiple ingredients in Rosa roxburghii and R . sterilis fruits and their antioxidant activities. Journal of Functional Foods. 2016; 27 ():29-41.
Chicago/Turabian StyleJing-Yu He; Yuan-He Zhang; Na Ma; Xu-Lin Zhang; Meng-Hua Liu; Wei-Ming Fu. 2016. "Comparative analysis of multiple ingredients in Rosa roxburghii and R . sterilis fruits and their antioxidant activities." Journal of Functional Foods 27, no. : 29-41.
Andrographis paniculata (Burm. f.) Nees (APN), a principal constituent of a famous traditional Chinese medicine Fukeqianjin tablet which is used for the treatment of pelvic inflammatory disease (PID), has been reported to have anti-inflammatory effect in vitro. However, whether it has pharmacological effect on PID in vivo is unclear. Therefore, the aim of this study is to test the anti-inflammatory effect of APN and illuminate a potential mechanism. Thirty-six female specific pathogen-free SD rats were randomly divided into control group, PID group, APN1 group, APN2 group, APN3 group and prednisone group. Pathogen-induced PID rats were constructed. The APN1, APN2 and APN3 group rats were orally administrated with APN extract at different levels. The prednisone group rats were administrated with prednisone. Eight days after the first infection, the histological examination of upper genital tract was carried out, and enzyme-linked immunosorbent assay (ELISA) was carried out using homogenate of the uterus and fallopian tube. Furthermore, immunohistochemical evaluations of NF-κB p65 and IκB-α in uterus was conducted. APN obviously suppressed the infiltrations of neutrophils and lymphocytes, and it could significantly reduce the excessive production of cytokines and chemokines including IL-1β, IL-6, CXCL-1, MCP-1 and RANTES in a dose-dependent manner. Furthermore, APN could block the pathogen-induced activation of NF-κB pathway. APN showed potent anti-inflammatory effect on pathogen-induced PID in rats, with a potential mechanism of inhibiting the NF-κB signal pathway.
Wei Zou; Zuoqi Xiao; Xiaoke Wen; Jieying Luo; Shuqiong Chen; Zeneng Cheng; Daxiong Xiang; Jian Hu; Jingyu He. The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway. BMC Complementary and Alternative Medicine 2016, 16, 1 -7.
AMA StyleWei Zou, Zuoqi Xiao, Xiaoke Wen, Jieying Luo, Shuqiong Chen, Zeneng Cheng, Daxiong Xiang, Jian Hu, Jingyu He. The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway. BMC Complementary and Alternative Medicine. 2016; 16 (1):1-7.
Chicago/Turabian StyleWei Zou; Zuoqi Xiao; Xiaoke Wen; Jieying Luo; Shuqiong Chen; Zeneng Cheng; Daxiong Xiang; Jian Hu; Jingyu He. 2016. "The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway." BMC Complementary and Alternative Medicine 16, no. 1: 1-7.
Both Rosa roxburghii and R. sterilis, belonging to the Rosaceae, are endemic species in Guizhou Province, China. The fruits of these two species are mixed-used as functional food in the region. Aiming to elucidate the phytochemical characteristics of R. roxburghii and R. sterilis fruits, the essential oils and constituents in a methanol extract have been analyzed and compared by GC-MS and UFLC/Q-TOF-MS, respectively. As a result, a total of 135 volatile compounds were identified by GC-MS and 91 components were different between R. roxburghii and R. sterilis fruits; a total of 59 compounds in methanol extracts were identified by UFLC/Q-TOF-MS, including 13 organic acids, 12 flavonoids, 11 triterpenes, nine amino acids, five phenylpropanoid derivatives, four condensed tannins, two stilbenes, two benzaldehyde derivatives and one benzoic acid derivative; and nine characteristic compounds were found between R. roxburghii and R. sterilis fruits. This systematic study plays an important role for R. roxburghii and R. sterilis fruits in the product development.
Meng-Hua Liu; Qi Zhang; Yuan-He Zhang; Xian-Yuan Lu; Wei-Ming Fu; Derek J. McPhee. Chemical Analysis of Dietary Constituents in Rosa roxburghii and Rosa sterilis Fruits. Molecules 2016, 21, 1204 .
AMA StyleMeng-Hua Liu, Qi Zhang, Yuan-He Zhang, Xian-Yuan Lu, Wei-Ming Fu, Derek J. McPhee. Chemical Analysis of Dietary Constituents in Rosa roxburghii and Rosa sterilis Fruits. Molecules. 2016; 21 (9):1204.
Chicago/Turabian StyleMeng-Hua Liu; Qi Zhang; Yuan-He Zhang; Xian-Yuan Lu; Wei-Ming Fu; Derek J. McPhee. 2016. "Chemical Analysis of Dietary Constituents in Rosa roxburghii and Rosa sterilis Fruits." Molecules 21, no. 9: 1204.
Hedyotis diffusa Willd (H. diffusa) is a well-known Chinese medicine with a variety of activities, especially its anti-cancer effect in the clinic. Up to now, 171 compounds have been reported from H. diffusa, including 32 iridoids, 26 flavonoids, 24 anthraquinones, 26 phenolics and their derivatives, 50 volatile oils and 13 miscellaneous compounds. In vitro and in vivo studies show these phytochemicals and plant extracts to exhibit a range of pharmacological activities of anti-cancer, antioxidant, anti-inflammatory, anti-fibroblast, immunomodulatory and neuroprotective effects. Although a series of methods have been established for the quality control of H. diffusa, a feasible and reliable approach is still needed in consideration of its botanical origin, collecting time and bioactive effects. Meanwhile, more pharmacokinetics researches are needed to illustrate the characteristics of H. diffusa in vivo. The present review aims to provide up-to-date and comprehensive information on the phytochemistry, pharmacology, quality control and pharmacokinetic characteristics of H. diffusa for its clinical use and further development.
Rui Chen; Jingyu He; Xueli Tong; Lan Tang; Menghua Liu. The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics. Molecules 2016, 21, 710 .
AMA StyleRui Chen, Jingyu He, Xueli Tong, Lan Tang, Menghua Liu. The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics. Molecules. 2016; 21 (6):710.
Chicago/Turabian StyleRui Chen; Jingyu He; Xueli Tong; Lan Tang; Menghua Liu. 2016. "The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics." Molecules 21, no. 6: 710.
Bambusa textilis McClure (Bambusoideae) is a valuable bamboo species widely distributed in southern China. The methanolic extract of B. textilis leaves was examined for its chemical and bioactive properties. As a result, 38 compounds, including organic acids, flavonoids and miscellaneous substances, were identified or tentatively characterised by UFLC-DAD-Q-TOF-MS. Thirteen polyphenols, considered as the most important components, were quantified using LC-MS/MS method. Moreover, the methanolic extract of B. textilis leaves had obvious antioxidant and anti-obesity activities in vivo in a high-fat diet rat model. It also had a significant antioxidant effect in 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and inhibition of β-carotene bleaching assays in vitro. These results are useful for further research of B. textilis leaves that may be useful candidates for the development as a functional food ingredient in health-related industries.
Meng-Hua Liu; Chun-Hay Ko; Na Ma; Pei-Wen Tan; Wei-Ming Fu; Jing-Yu He. Chemical profiles, antioxidant and anti-obesity effects of extract of Bambusa textilis McClure leaves. Journal of Functional Foods 2016, 22, 533 -546.
AMA StyleMeng-Hua Liu, Chun-Hay Ko, Na Ma, Pei-Wen Tan, Wei-Ming Fu, Jing-Yu He. Chemical profiles, antioxidant and anti-obesity effects of extract of Bambusa textilis McClure leaves. Journal of Functional Foods. 2016; 22 ():533-546.
Chicago/Turabian StyleMeng-Hua Liu; Chun-Hay Ko; Na Ma; Pei-Wen Tan; Wei-Ming Fu; Jing-Yu He. 2016. "Chemical profiles, antioxidant and anti-obesity effects of extract of Bambusa textilis McClure leaves." Journal of Functional Foods 22, no. : 533-546.
Protective effect of Hedyotis diffusa (H. diffusa) Willd against lipopolysaccharide (LPS)-induced renal inflammation was evaluated by the productions of cytokines and chemokine, and the bioactive constituents of H. diffusa were detected by the ultra-fast liquid chromatography -diode array detector-quadrupole-time of flight mass spectrometry (UFLC-DAD-Q-TOF-MS/MS) method. As the results showed, water extract of H. diffusa (equal to 5.0 g/kg body weight) obviously protected renal tissues, significantly suppressed the productions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein (MCP)-1, as well as significantly promoted the production of IL-10 in serum and renal tissues. According the chemical profiles of H. diffusa, flavonoids, iridoid glycosides and anthraquinones were greatly detected in serum from H. diffusa extract treatment mice. Two main chemotypes, including eight flavonoids and four iridoid glycosides were found in renal tissues from H. diffusa extract treatment mice. The results demonstrated that water extract of H. diffusa had protective effect on renal inflammation, which possibly resulted from the bioactive constituents consisting of flavonoids, iridoids and anthraquinones.
Jian-Hong Ye; Meng-Hua Liu; Xu-Lin Zhang; Jing-Yu He. Chemical Profiles and Protective Effect of Hedyotis diffusa Willd in Lipopolysaccharide-Induced Renal Inflammation Mice. International Journal of Molecular Sciences 2015, 16, 27252 -27269.
AMA StyleJian-Hong Ye, Meng-Hua Liu, Xu-Lin Zhang, Jing-Yu He. Chemical Profiles and Protective Effect of Hedyotis diffusa Willd in Lipopolysaccharide-Induced Renal Inflammation Mice. International Journal of Molecular Sciences. 2015; 16 (11):27252-27269.
Chicago/Turabian StyleJian-Hong Ye; Meng-Hua Liu; Xu-Lin Zhang; Jing-Yu He. 2015. "Chemical Profiles and Protective Effect of Hedyotis diffusa Willd in Lipopolysaccharide-Induced Renal Inflammation Mice." International Journal of Molecular Sciences 16, no. 11: 27252-27269.
Radix Astragali (RA) is one of the commonly-used traditional Chinese medicines (TCMs) with an immunomodulatory effect confirmed in the clinic. In order to better understand the material basis for the therapeutic effects, this study was to investigate the absorbed components and their pharmacokinetic profile after oral administration of RA on cyclophosphamide-induced immunosuppression in Balb/c mice. As a result, 51 compounds in RA extract and 31 prototype compounds with nine metabolites were detected in mice plasma by the ultra-fast liquid chromatography (UFLC)-DAD-Q-TOF-MS/MS method. The pharmacokinetic parameters of five main constituents, including calycosin-7-O-glucoside, ononin, calycosin, formononetin and astragaloside IV, were obtained using HPLC-MS/MS. These results offered useful information for research on the pharmacological mechanism of RA and for its further development.
Menghua Liu; Panlin Li; Xuan Zeng; Huanxian Wu; Weiwei Su; Jingyu He. Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice. International Journal of Molecular Sciences 2015, 16, 5047 -5071.
AMA StyleMenghua Liu, Panlin Li, Xuan Zeng, Huanxian Wu, Weiwei Su, Jingyu He. Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice. International Journal of Molecular Sciences. 2015; 16 (3):5047-5071.
Chicago/Turabian StyleMenghua Liu; Panlin Li; Xuan Zeng; Huanxian Wu; Weiwei Su; Jingyu He. 2015. "Identification and Pharmacokinetics of Multiple Potential Bioactive Constituents after Oral Administration of Radix Astragali on Cyclophosphamide-Induced Immunosuppression in Balb/c Mice." International Journal of Molecular Sciences 16, no. 3: 5047-5071.
Hypericum japonicum Thunb. ex Murray is mainly distributed throughout Asia, Oceania and North America and is used as an important herbal medicine. H. japonicum contains many valuable secondary metabolites, such as flavonoids, phloroglucinols and xanthones and has hepatoprotective, anti-tumor, antibacterial, antiviral, and antioxidant activities and effects on the cardiovascular system and immunity. Coupled with phytochemical and pharmacological research, a series of analytical methods have been developed to evaluate the quality of H. japonicum based on its bioactive components. A pharmacokinetics study involved the absorption of two main flavonoids of H. japonicum in rats. This review aims to present an up-to-date and comprehensive overview of the phytochemistry, pharmacology, quality control and pharmacokinetics of H. japonicum, which should be useful for the greater development of H. japonicum, especially in the development of new drugs and therapeutics for various diseases.
Lin-Sheng Liu; Meng-Hua Liu; Jing-Yu He. Hypericum japonicum Thunb. ex Murray: Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics of an Important Herbal Medicine. Molecules 2014, 19, 10733 -10754.
AMA StyleLin-Sheng Liu, Meng-Hua Liu, Jing-Yu He. Hypericum japonicum Thunb. ex Murray: Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics of an Important Herbal Medicine. Molecules. 2014; 19 (8):10733-10754.
Chicago/Turabian StyleLin-Sheng Liu; Meng-Hua Liu; Jing-Yu He. 2014. "Hypericum japonicum Thunb. ex Murray: Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics of an Important Herbal Medicine." Molecules 19, no. 8: 10733-10754.