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Dr. Mingkai Li
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Academic Career Length
14Years (2013-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications18 January 2020 in Journal of Biomedical Science
Journal Article
DNDan Nie
Dan NieYHYue Hu
Yue HuZCZhou Chen
Zhou ChenMLMingkai Li
Mingkai LiZHZheng Hou
Zheng HouXXXiaoyan Xue
Xiaoyan Xue +2
Acinetobacter baumannii(A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA inEscherichia coli(E. coli) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA inA. baumannii. In this review, we summarized the structure and functions of OmpA inA. baumannii(AbOmpA), collected novel therapeutic strategies against it for treatingA. baumanniiinfection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target.
24 July 2020 in Science Advances
Journal Article
DQDi Qu
Di QuZHZheng Hou
Zheng HouJLJing Li
Jing LiLLLiyang Luo
Liyang LuoSSShan Su
Shan SuMLMingkai Li
Mingkai Li +8
Coumarin compound DCH combats methicillin-resistant Staphylococcus aureus infection via inhibiting bacterial arginine repressor.
20 April 2021 in Genes & Diseases
Journal Article
Infections caused by viruses are one of the foremost causes of morbidity and mortality in the world. Although a number of antiviral drugs are currently used for treatment of various kinds of viral infection diseases, there is still no available therapeutic agent for most of the viruses in clinical practice. Coumarin is a chemical compound which is found naturally in a variety of plants, it can also be synthetically produced possessing diverse biological effects. More recently, reports have highlighted the potential role of coumarin derivatives as antiviral agents. This review outlines the advances in coumarin-based compounds against various viruses including human immunodeficiency virus, hepatitis virus, herpes simplex virus, Chikungunya virus and Enterovirus 71, as well as the structure activity relationship and the possible mechanism of action of the most potent coumarin derivatives.
26 June 2023 in EMBO Reports
Journal Article
CFChao Fang
Chao FangPRPan Ren
Pan RenGBGanlan Bian
Ganlan BianJWJian Wang
Jian Wang
JBJiaxin Bai
Jiaxin Bai
ZHZheng Hou
Zheng Hou +4
Journal Article
JLJing Li
Jing LiCLChang-Wei Lv
Chang-Wei LvXLXiaojun Li
Xiaojun LiDQDi Qu
Di QuZHZheng Hou
Zheng HouMLMingkai Li
Mingkai Li +3
In an attempt to find a new class antibacterial agents, a series of biscoumarins (1–4) and dihydropyrans (5–13) were successfully prepared. The molecular structures of four representative compounds, that is, 4, 5, 8 and 12 were confirmed by single crystal X-ray diffraction study. These synthesized compounds were screened for their antibacterial activity in vitro against Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), USA 300 (Los Angeles County clone, LAC), Staphylococcus epidermidis (S. epidermidis ATCC 14990), methicillin-resistant S. epidermidis (MRSE XJ 75284) and Escherichia coli (E. coli ATCC 25922). Additionally, there are two classical intramolecular O–H···O hydrogen bonds (HBs) in biscoumarins 1–4 and the corresponding HB energies were further performed with the density functional theory (DFT) [B3LYP/6-31G*] method.
6 January 2015 in Research on Chemical Intermediates
Journal Article
JLJing Li
Jing Li
JMJing-Ru Meng
Jing-Ru Meng
DQDi Qu
Di Qu
ZZZi-Dan Zhang
Zi-Dan Zhang
FLFen Li
Fen Li
MLMingkai Li
Mingkai Li +3
About Me
Mingkai Li
Associate Professor, Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an China. Dr. Li obtained his Doctorate degree from the Fourth Military Medical University in 2005 and finished his Postdoctoral research job at School of medicine, the University of Maryland, United States in 2010. At present, he serves as the Dean of Department of Pharmacology, Associate director of Research center of Precise medication & innovative drug, Fourth Military Medical University, China. He is the Chairman of society of anti-infections agents and Pharmacology in Shaanxi Province. His main research is development of novel antibacterial and antiviral agents. He has presided or finished over 10 projects, including the National Natural Science Foundation Projects He has published more than 50 papers and obtained 12 China Invention Patens. He received three scientific research awards from Shaanxi Provincial Department of Science and Technology.