Degree in Pharmacy and Biochemistry from University of São Paulo (USP), Master and PhD in Pharmacology from USP, and Post doctorate from the Massachusetts General Hospital - Harvard Medical School, Boston, USA. Associate-Professor at USP (2003) and Member of the São Paulo State Academy of Sciences (2012) and Head of Department of Pharmacology (2013-2017). He is currently Professor of Department of Pharmacology of the Institute of Biomedical Sciences at USP (2009-). He contributed in the area of Pharmacology and Neurosciences, with an emphasis on aging and the signaling cascade related to degenerative diseases, introducing new knowledge in studies of adaptive responses associated with hormesis, rare, neurological, and neuropsychiatric diseases, and aging, involving the signaling of cardiotonic steroids, Na,K-ATPase (NKA), glucocorticoids, Klotho, and glutamate. Member of the Editorial Board of Plos One, Scientific Reports, British Journal of Pharmacology, Frontiers in Endocrinology, and Frontiers in Aging Neuroscience. Co-founder of the startup Synatria Biotech aiming at new drugs for ischemia, epilepsy, rare diseases such as Alternating Hemiplegia of Childhood (AHC), and other pathologies associated with NKA signaling and activity.