Point-of-care (PoC) diagnostics is promising for early detection of a number of diseases, including cancer, diabetes, and cardiovascular diseases, in addition to serving for monitoring health conditions. To be efficient and cost-effective, portable PoC devices are made with microfluidic technologies, with which laboratory analysis can be made with small-volume samples. Recent years have witnessed considerable progress in this area with “epidermal electronics”, including miniaturized wearable diagnosis devices. These wearable devices allow for continuous real-time transmission of biological data to the Internet for further processing and transformation into clinical knowledge. Other approaches include bluetooth and WiFi technology for data transmission from portable (non-wearable) diagnosis devices to cellphones or computers, and then to the Internet for communication with centralized healthcare structures. There are, however, considerable challenges to be faced before PoC devices become routine in the clinical practice. For instance, the implementation of this technology requires integration of detection components with other fluid regulatory elements at the microscale, where fluid-flow properties become increasingly controlled by viscous forces rather than inertial forces. Another challenge is to develop new materials for environmentally friendly, cheap, and portable microfluidic devices. In this review paper, we first revisit the progress made in the last few years and discuss trends and strategies for the fabrication of microfluidic devices. Then, we discuss the challenges in lab-on-a-chip biosensing devices, including colorimetric sensors coupled to smartphones, plasmonic sensors, and electronic tongues. The latter ones use statistical and big data analysis for proper classification. The increasing use of big data and artificial intelligence methods is then commented upon in the context of wearable and handled biosensing platforms for the Internet of things and futuristic healthcare systems.

We propose a highly sensitive sensor based on enhancing the transversal magneto-optical Kerr effect (TMOKE) through excitation of surface plasmon resonances in a novel and simple architecture, which consists of a metal grating on a metal magneto-optical layer. Detection of the change in the refractive index of the analyte medium is made by monitoring the angular shift of the Fano-like resonances associated with TMOKE. A higher resolution is obtained with this technique than with reflectance curves. The key aspect of the novel architecture is to achieve excitation of surface plasmon resonances mainly localized at the sensing layer, where interaction with the analyte occurs. This led to a high sensitivity, S = 190° RIU^–1, and high performance with a figure of merit of the order of 10³, which can be exploited in sensors and biosensors.

The engineering of the spatial and temporal properties of both the electric permittivity and the refractive index of materials is at the core of photonics. When vanishing to zero, those two variables provide efficient knobs to control light-matter interactions. This Perspective aims at providing an overview of the state of the art and the challenges in emerging research areas where the use of near-zero refractive index and hyperbolic metamaterials is pivotal, in particular, light and thermal emission, nonlinear optics, sensing applications, and time-varying photonics.

Surface plasmon resonance (SPR) biosensing is based on the detection of small changes in the refractive index on a gold surface modified with molecular recognition materials, thus being mostly limited to detecting large molecules. In this paper, we report on a SPR biosensing platform suitable to detect small molecules by making use of the mediator-type enzyme microperoxidase-11 (MP11) in layer-by-layer films. By depositing a top layer of glucose oxidase or uricase, we were able to detect glucose or uric acid with limits of detection of 3.4 and 0.27 μ mol l ⁻¹ , respectively. Measurable SPR signals could be achieved because of the changes in polarizability of MP11, as it is oxidized upon interaction with the analyte. Confirmation of this hypothesis was obtained with finite difference time domain simulations, which also allowed us to discard the possible effects from film roughness changes observed in atomic force microscopy images. The main advantage of this mediator-type enzyme approach is in the simplicity of the experimental method that does not require an external potential, unlike similar approaches for SPR biosensing of small molecules. The detection limits reported here were achieved without optimizing the film architecture, and therefore the performance can in principle be further enhanced, while the proposed SPR platform may be extended to any system where hydrogen peroxide is generated in enzymatic reactions.

Magneto-optics (MO) is an effervescent research field, with a wide range of potential industrial applications including sensing, theranostics, pharmaceutics, magnetometry, and spectroscopy, among others. This review discusses the historical development, from the discovery of MO effects up to the most recent application trends. In addition to the consolidated fields of magnetoplasmonic sensing and modulation of optical signals, we describe novel MO materials, phenomena, and applications. We also identified the emerging field of all-dielectric magnetophotonics, which hold promise to overcome dissipation from metallic inclusions in plasmonic nanostructures. Moreover, we identified some challenges, such as the need to merge magneto-chiroptical effects with microfluidics technology, for chiral sensing and enantioseparation of drugs in the pharmaceutical industry. Other potential industrial applications are discussed in light of recent research achievements in the available literature.