Amination of phenylene moieties in crystal-like mesoporous silica hybridized with phenylene is successfully achieved with close to 28% conversion of phenylene by a two-step chemical transformation process while preserving both the ordered mesostructure and crystal-like molecular scale periodicity of the parent material.

The preventive efficacies and safety of Emblica Officinalis Gatertn (Amla), a most important and extensively studied plant in the traditional Indian Ayurvedic system of medicine, are presented. Eligible healthy adult subjects (n = 15) were randomized to receive either amla or placebo (500 mg per day) during an 18-week study. The efficacy parameters evaluated were the vascular function, blood hematology, oxidative and inflammatory biomarkers, glucose and lipid profiles, urinalysis, and liver hepatotoxicity. The amla intake showed significant improvements in the primary efficacy parameter of blood fluidity. There were also improvements in the secondary endpoints including lowering of von Willebrand factor (vWF), reduced 8-hydroxy-2'-deoxyguanosine (8-OHdG) as well as thrombin (TM) biomarkers of oxidative stress along with a significant improvement in HDL-cholesterol and lowering the LDL-cholesterol levels. No substantial changes were observed in liver hepatotoxicity, urinalysis, and hematology after consumption of amla compared to baseline or placebo. In addition, no adverse events, changes safety parameters or tolerance issues were observed after consumption of amla. In conclusion, amla supplementation showed acceptable palatability, improved endothelial functions and reduced oxidative stress.

Organosilica porous solids containing chiral organic moieties in the framework with an enantiomeric purity of 95% ee, estimated by eluting organic constituent units from chiral organosilicas, were synthesized from a newly designed chiral (R)-(+)-1,2-bis(trimethoxysilyl)phenylethane precursor via a surfactant-mediated self-assembly approach.