Due to the difference in distance cognition between virtual and real symmetric space, it is difficult for users to accurately interact with the target in the Digital Twin system. In order to study the cross-effects of interaction task, target size and target location on the accuracy of egocentric peripersonal distance cognition, a 2 × 5 × 9 × 5 asymmetric experiment was designed and carried out. There were two kinds of interaction tasks, five kinds of interaction target widths and nine kinds of spatial locations set to estimate the five egocentric peripersonal distances. Based on the experimental data, with interaction task, target width and the actual spatial location as independent variables and virtual interaction location as a dependent variable, the mapping model between the actual physical location and virtual interaction location of different interaction targets was constructed and evaluated by multiple linear regression method. The results showed that the prediction model constructed by stepwise regression method was simple and less computationally intensive, but it had better stability and prediction ability. The correlation coefficients R² on xp, yp and zp were 0.994, 0.999 and 0.998, RMSE values were 2.583 cm, 1.0774 cm and 1.3155 cm, rRMSE values were 26.57%, 12.60% and 1.15%, respectively. The research of relevant experiments and the construction of models are helpful to solve the layout optimization problem of virtual interactive space in the Digital Twin system.