The environmental pollution that occurs in direct response to the widespread use of man-made/conventional pesticides results from many chemicals that require a long period of time, often decades, to degrade. The synthetic nature of pesticides also harms animals, beneficial insects, microorganisms, and plants, as well as humans. Fortunately, however, there are many natural pesticides, the so-called biopesticides, that are also effective against pests and more importantly, do not interfere with the well-being of ecosystems. Consequently, most biopesticides are safer for use around people and pets than man-made pesticides because, for example, they can be easily washed away from fruits and vegetables. The natural habitat is a rich resource with a wide selection of plants, many of which are also used to treat diseases in humans, animals, and plants. Out of concern for public health, environmental safety, and the stringent regulation of pesticide residues in agricultural commodities, the use of biopesticides is becoming increasingly important, but questions regarding potential pest resistance to these products may arise, just as is the case with conventional pesticides. Therefore, the performance and potential role of biopesticides in the management of plant pests should be prioritized due to their sustainability and importance to human and environmental welfare. In this review, we propose to highlight a scenario in which we discuss in detail the main constraints posed by the use of pesticides compared to biopesticides, starting with issues regarding their definition and continuing on to issues related to their toxicity and their impact on the environment and human health.

Persistent toxic substances including persistent organic pollutants and heavy metals have been released in high quantities in surface waters by industrial activities. Their presence in environmental compartments is causing harmful effects both on the environment and human health. It was shown that their removal from wastewaters using conventional methods and adsorbents is not always a sustainable process. In this circumstance, the use of microorganisms for pollutants uptake can be seen as being an environmentally-friendly and cost-effective strategy for the treatment of industrial effluents. However, in spite of their confirmed potential in the remediation of persistent pollutants, microorganisms are not yet applied at industrial scale. Thus, the current paper aims to synthesize and analyze the available data from literature to support the upscaling of microbial-based biosorption and bioaccumulation processes. The industrial sources of persistent pollutants, the microbial mechanisms for pollutant uptake and the significant results revealed so far in the scientific literature are identified and covered in this review. Moreover, the influence of different parameters affecting the performance of the discussed systems and also very important in designing of treatment processes are highly considered. The analysis performed in the paper offers an important perspective in making decisions for scaling-up and efficient operation, from the life cycle assessment point of view of wastewater microbial bioremediation. This is significant since the sustainability of the microbial-based remediation processes through standardized methodologies such as life cycle analysis (LCA), hasn’t been analyzed yet in the scientific literature.

Accelerating heavy metal pollution is a hot issue due to a continuous growth in consumerism and increased activities in various global industries. Soil contamination with heavy metals has resulted in their incorporation into the human food web via plant components. Accumulation and amplification of heavy metals in human tissues through the consumption of medicinal plants can have hazardous health outcomes. Therefore, in this critical review we aim to bring together published information on this subject, with a special highlight on the knowledge gaps related to heavy metal stress in medicinal plants, their responses, and human health related risks. In this respect, this review outlines the key contamination sources of heavy metals in plants, as well as the absorption, mobilization and translocation of metal ions in plant compartments, while considering their respective mechanisms of detoxification. In addition, this literature review attempts to highlight how stress and defensive strategies operate in plants, pointing out the main stressors, either biotic or abiotic (e.g., heavy metals), and the role of reactive oxygen species (ROS) in stress answers. Finally, in our research, we further aim to capture the risks caused by heavy metals in medicinal plants to human health through the assessment of both a hazard quotient (HQ) and hazard index (HI).