Dr. Pascal Mailley
Micro-technologies for Biology and Healthcare Division, CEA, LETI, MINATEC Campus, University Grenoble Alpes, F-38054 Grenoble, France
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Academic Career Length
24Years (2003-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications2 July 2008 in The Analyst
Journal Article
SCSerge Cosnier
Serge CosnierPascal MailleyThe concept of DNA biosensors is sustained by the need for rapid and highly sensitive analytical tools for genetic detection. Their implementation is based on three key steps: (i) immobilization of single-stranded oligonucleotide probes onto a substrate; (ii) hybridization and (iii) reading. These steps involve complementary knowledge in various disciplinary fields such as surface physics and chemistry, molecular electrochemistry, micro-technologies, optics, electronics and biochemistry. We present here, in a non-exhaustive way, the recent advances in the two steps of immobilization and detection that rely upon increasing integration of the number of reading points or/and of the reading strategy.
5 November 2009 in Physical Chemistry Chemical Physics
Journal Article
CACharles Agnès
Charles Agnès
Jean-Charles ArnaultFOFranck Omnès
Franck Omnès
BJBruno Jousselme
Bruno JousselmeMBMartial Billon
Martial Billon
Pascal Mailley +1
Boron doped diamond (BDD) functionalization has received an increasing interest during the last few years. Such an infatuation comes from the original properties of BDD, including chemical stability or an electrochemical window, that opens the way for the design of (bio)sensors or smart interfaces. In such a context, diazonium salts appear to be well suited for BDD functionalization as they enable covalent immobilization of functional entities such as enzymes or DNA. In this study we report microcrystalline BDD functionalization with a metallic complex, ruthenium tris(bipyridine), using the p-(tris(bipyridine)Ru2+)phenyl diazonium salt. Electrografting using cyclic voltammetry (CV) allowed the formation of a ruthenium complex film that was finely characterized using electrochemistry and X-ray photoelectron spectroscopy (XPS). Moreover, we showed that chronopotentiometry (CP) is a convenient tool to monitor Ru complex film deposition through the control of the electrochemical pulse parameters (i.e. current density and pulse duration). Finally, such a control was demonstrated through the correlation between electrochemical and XPS characterizations.
15 November 2016 in Advanced Materials Technologies
Journal Article
GSGaëtan Scheiblin
Gaëtan Scheiblin
RCRomain Coppard
Romain Coppard
RORóisín M. Owens
Róisín M. Owens
Pascal MailleyGMGeorge Malliaras
George Malliaras1 September 2015 in MRS Communications
Journal Article
GSGaëtan Scheiblin
Gaëtan Scheiblin
AAAbdelkader Aliane
Abdelkader Aliane
XSXenofon Strakosas
Xenofon Strakosas
VCVincenzo F. Curto
Vincenzo F. Curto
RCRomain Coppard
Romain Coppard
GMGeorge Malliaras
George Malliaras +3
Journal Article
RKRaphael Kiran
Raphael KiranLRLionel Rousseau
Lionel RousseauGLGaëlle Lissorgues
Gaëlle LissorguesESEmmanuel Scorsone
Emmanuel ScorsoneABAlexandre Bongrain
Alexandre BongrainPBPhilippe Bergonzo
Philippe Bergonzo +3
We report on the fabrication and characterization of an 8 × 8 multichannel Boron Doped Diamond (BDD) ultramicro-electrode array (UMEA). The device combines both the assets of microelectrodes, resulting from conditions in mass transport from the bulk solution toward the electrode, and of BDD’s remarkable intrinsic electrochemical properties. The UMEAs were fabricated using an original approach relying on the selective growth of diamond over pre-processed 4 inches silicon substrates. The prepared UMEAs were characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The results demonstrated that the electrodes have exhibited a very fast electrode transfer rate (k0) up to 0.05 cm∙s−1 (in a fast redox couple) and on average, a steady state limiting current (in a 0.5 M potassium chloride aqueous solution containing 1 mM Fe(CN)64− ion at 100 mV∙s−1) of 1.8 nA. The UMEAs are targeted for electrophysiological as well as analytical applications.
26 June 2019 in Analytical Chemistry
Journal Article
AIAbdulghani Ismail
Abdulghani Ismail
SVSilvia Voci
Silvia VociPPPascale Pham
Pascale Pham
LLLoïc Leroy
Loïc Leroy
AMAli Maziz
Ali Maziz
Neso Sojic +7
About Me
Dr. Pascal Mailley is the director of research at CEA and is currently the head of research for the CEA-Leti health division. He is currently working on electrochemical sensors for environmental and medical applications. He obtained an MSc in material engineering (1992) and a PhD in electrochemistry (1995) from the University of Grenoble in France. After his PhD, Dr. Mailley worked for two years in the pharmaceutical industry on the development of electrically assisted transdermal drug delivery devices before joining the University of Ulster in Northern Ireland as a lecturer, where he developed biosensors for food analysis and medical electrodes for implant and monitoring. Before joining the CEA-Leti health division, he worked for thirteen years as a lecturer at the University of Grenoble. During this period, his research projects were dedicated to the design of bioelectronic devices, the use of new carbon materials (nanotubes, diamond, graphene, and electronically conducting polymers) for the design of analytical platforms, and the development of new electrochemical concepts. He is author or coauthor of 85 publications (with an h-index of 29) and 13 patents in bioelectronics, biosensors, and surface chemistry.