Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities such as anti-leukotriene, antineoplastic, analgesic, anti-oxidant, immunostimulatory, and rejuvenating properties, mainly observed by in vitro demonstration. However, the course of its medical use remains unknown. This review provides a comprehensive understanding of W. somnifera, which will be useful for mechanism studies and potential medical applications of W. somnifera, as well as for the development of a rational quality control system for W. somnifera as a therapeutic material in the future.

Zingiber officinale L. Roscoe is a significant herb that possesses many medicinal and ethnomedicinal properties. Due to the presence of various bioactive compounds, it has immense healing capacity. However, ginger as a crop is susceptible to several fungal pathogens. Among all the fungal pathogens, Pythium and Fusarium spp. are of most concern, causing soft rot (rhizome rot) disease, majorly responsible for the downfall in its production by 50–90%. Pesticides and fungicides spray is generally recommended for the control of soft rot. Ample use of chemicals not only affects the quality of the crop but also disturbs ecological integrity. Therefore, biological methods of disease management involving suitable microbial agents such as Trichoderma harzianum, Pseudomonas spp., Bacillus subtilis, Streptomyces spp. and plant extracts are attracting and gaining importance as a part of integrated approaches (IPM) to manage the soft rot and sustainably enhance the production and improve the medicinal and pharmaceutical values of ginger. The present review is aimed to discuss various means of controlling soft rot disease by physical, chemical, biological, and nanotechnology-based methods. Moreover, various bioactive constituents of ginger and their pharmaceutical importance have been also discussed.

Skin disease associated with keratinized tissues in animal and human beings has been investigated. The essential oil of Eucalyptus pauciflora in vitro showed strong antifungal activity at 1.0 μl/ml against human pathogenic fungi, viz. Epidermophyton floccosum, Microsporum audouinii, M. canis, M. gypseum, M. nanum, Trichophyton mentagrophytes, T. rubrum, T. tonsurans and T. violaceum. The oil has heavy doses of inoculum potential at 1.0 μl/ml. Moreover, it did not exhibit any adverse effects on mammalian skin up to 5% concentrations. Further, we formulated the oil in the form of ointment ‘BSHT’ (broad spectrum herbal therapy) (1% v/v) and subjected it to topical testing on patients attending the outpatient department of M.L.N. Medical College, Allahabad. Fifty patients were selected on the basis of KOH-positive results and diagnosed as either tinea pedis, tinea corporis or tinea cruris. After the second week of treatment, all patients were KOH-negative. At the end of medication, 60% of patients recovered completely and 40% showed significant improvement from the disease. No KOH-negative cases of relapse were observed when patients were re-examined after 2 months following the end of treatment. Thus, the ointment can be exploited commercially after undergoing successful multicenter clinical trials, which are in progress.