This page has only limited features, please log in for full access.

Unclaimed
Luis Felipe Santos Menezes
Laboratório de Neurofarmacologia, Departamento de Ciências Fisiológicas, Universidade de Brasília, Brazil

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Review
Published: 18 August 2020 in Frontiers in Pharmacology
Reads 0
Downloads 0

Epilepsy is a disease characterized by abnormal brain activity and a predisposition to generate epileptic seizures, leading to neurobiological, cognitive, psychological, social, and economic impacts for the patient. There are several known causes for epilepsy; one of them is the malfunction of ion channels, resulting from mutations. Voltage-gated sodium channels (NaV) play an essential role in the generation and propagation of action potential, and malfunction caused by mutations can induce irregular neuronal activity. That said, several genetic variations in NaV channels have been described and associated with epilepsy. These mutations can affect channel kinetics, modifying channel activation, inactivation, recovery from inactivation, and/or the current window. Among the NaV subtypes related to epilepsy, NaV1.1 is doubtless the most relevant, with more than 1500 mutations described. Truncation and missense mutations are the most observed alterations. In addition, several studies have already related mutated NaV channels with the electrophysiological functioning of the channel, aiming to correlate with the epilepsy phenotype. The present review provides an overview of studies on epilepsy-associated mutated human NaV1.1, NaV1.2, NaV1.3, NaV1.6, and NaV1.7.

ACS Style

Luis Felipe Santos Menezes; Elias Ferreira Sabiá Júnior; Diogo Vieira Tibery; Lilian Dos Anjos Carneiro; Elisabeth Ferroni Schwartz. Epilepsy-Related Voltage-Gated Sodium Channelopathies: A Review. Frontiers in Pharmacology 2020, 11, 1 .

AMA Style

Luis Felipe Santos Menezes, Elias Ferreira Sabiá Júnior, Diogo Vieira Tibery, Lilian Dos Anjos Carneiro, Elisabeth Ferroni Schwartz. Epilepsy-Related Voltage-Gated Sodium Channelopathies: A Review. Frontiers in Pharmacology. 2020; 11 ():1.

Chicago/Turabian Style

Luis Felipe Santos Menezes; Elias Ferreira Sabiá Júnior; Diogo Vieira Tibery; Lilian Dos Anjos Carneiro; Elisabeth Ferroni Schwartz. 2020. "Epilepsy-Related Voltage-Gated Sodium Channelopathies: A Review." Frontiers in Pharmacology 11, no. : 1.

Review
Published: 25 September 2019 in Toxins
Reads 0
Downloads 0

Arthropoda is a phylum of invertebrates that has undergone remarkable evolutionary radiation, with a wide range of venomous animals. Arthropod venom is a complex mixture of molecules and a source of new compounds, including antimicrobial peptides (AMPs). Most AMPs affect membrane integrity and produce lethal pores in microorganisms, including protozoan pathogens, whereas others act on internal targets or by modulation of the host immune system. Protozoan parasites cause some serious life-threatening diseases among millions of people worldwide, mostly affecting the poorest in developing tropical regions. Humans can be infected with protozoan parasites belonging to the genera Trypanosoma, Leishmania, Plasmodium, and Toxoplasma, responsible for Chagas disease, human African trypanosomiasis, leishmaniasis, malaria, and toxoplasmosis. There is not yet any cure or vaccine for these illnesses, and the current antiprotozoal chemotherapeutic compounds are inefficient and toxic and have been in clinical use for decades, which increases drug resistance. In this review, we will present an overview of AMPs, the diverse modes of action of AMPs on protozoan targets, and the prospection of novel AMPs isolated from venomous arthropods with the potential to become novel clinical agents to treat protozoan-borne diseases.

ACS Style

Elias Ferreira Sabiá Júnior; Luis Felipe Santos Menezes; Israel Flor Silva De Araújo; Elisabeth Ferroni Schwartz. Natural Occurrence in Venomous Arthropods of Antimicrobial Peptides Active against Protozoan Parasites. Toxins 2019, 11, 563 .

AMA Style

Elias Ferreira Sabiá Júnior, Luis Felipe Santos Menezes, Israel Flor Silva De Araújo, Elisabeth Ferroni Schwartz. Natural Occurrence in Venomous Arthropods of Antimicrobial Peptides Active against Protozoan Parasites. Toxins. 2019; 11 (10):563.

Chicago/Turabian Style

Elias Ferreira Sabiá Júnior; Luis Felipe Santos Menezes; Israel Flor Silva De Araújo; Elisabeth Ferroni Schwartz. 2019. "Natural Occurrence in Venomous Arthropods of Antimicrobial Peptides Active against Protozoan Parasites." Toxins 11, no. 10: 563.

Review
Published: 14 May 2019 in Molecules
Reads 0
Downloads 0

Venom from mammals, amphibians, snakes, arachnids, sea anemones and insects provides diverse sources of peptides with different potential medical applications. Several of these peptides have already been converted into drugs and some are still in the clinical phase. Diabetes type 2 is one of the diseases with the highest mortality rate worldwide, requiring specific attention. Diverse drugs are available (e.g., Sulfonylureas) for effective treatment, but with several adverse secondary effects, most of them related to the low specificity of these compounds to the target. In this context, the search for specific and high-affinity compounds for the management of this metabolic disease is growing. Toxins isolated from animal venom have high specificity and affinity for different molecular targets, of which the most important are ion channels. This review will present an overview about the electrical activity of the ion channels present in pancreatic β cells that are involved in the insulin secretion process, in addition to the diversity of peptides that can interact and modulate the electrical activity of pancreatic β cells. The importance of prospecting bioactive peptides for therapeutic use is also reinforced.

ACS Style

Beatriz Elena Sarmiento; Luis Felipe Santos Menezes; Elisabeth F. Schwartz. Insulin Release Mechanism Modulated by Toxins Isolated from Animal Venoms: From Basic Research to Drug Development Prospects. Molecules 2019, 24, 1846 .

AMA Style

Beatriz Elena Sarmiento, Luis Felipe Santos Menezes, Elisabeth F. Schwartz. Insulin Release Mechanism Modulated by Toxins Isolated from Animal Venoms: From Basic Research to Drug Development Prospects. Molecules. 2019; 24 (10):1846.

Chicago/Turabian Style

Beatriz Elena Sarmiento; Luis Felipe Santos Menezes; Elisabeth F. Schwartz. 2019. "Insulin Release Mechanism Modulated by Toxins Isolated from Animal Venoms: From Basic Research to Drug Development Prospects." Molecules 24, no. 10: 1846.