The population is now living longer during the period classified as “elderly” (60 years and older), exhibiting multimorbidity associated to the lengthening of the average life span. The dietary intake of phenolic compounds (PC) may affect the physiology, disease development and progression during the aging process, reducing risk factors of age related diseases. The aim of this review is to briefly describe some of the possible effects of a series of PC on the reduction of risk factors of the onset of cardiovascular diseases, considering their potential mechanisms of action. The main actions described for PC are associated with reduced platelet activity, anti-inflammatory effects, and the protection from oxidation to reduce LDL and the generation of advanced glycation end products. Preclinical and clinical evidence of the physiological effects of various PC is presented, as well as the health claims approved by regulatory agencies.

We examined the ability of tomato pomace extract (by-product) to affect platelet aggregation in healthy humans (clinical pilot study). In phase 1 the tolerance of participants (n = 15; 5 per dose level) ingesting tomato pomace extract across three dose levels (1, 2.5, and 10 g) was evaluated. Phase 2 was a single-blind, placebo-controlled, parallel design human (male, n = 99; 33 per group) pilot intervention trial investigating the acute and repeated dose effects (5 days) of different doses of tomato pomace extract (1 g, 2.5 g or placebo) on platelet aggregation ex vivo. Various flavonoids (coumaric acid, floridzin, floretin, procyanidin B₂, luteolin-7-O-glucoside, kaempferol, and quercitin) and nucleosides (adenosine, inosine, and guanosine) were identified in the tomato pomace extract. The clinical study showed that the daily consumption of 1 g of aqueous extract of tomato pomace for 5 days exerted an inhibitory activity on platelet aggregation.

Mediterranean pine nuts are recognized for their high nutritional value and healthy benefits. The aim of the study was to analyze the composition of pine nuts harvested from Pinus pinea L. across three different geographic macrozones in Chile. Proximate analysis, minerals, fatty acid composition, phytosterols, tocopherols, vitamin C, phenolic compounds, and antioxidant capacity were determined. The major component was fat (422.5±3.3–469.2±0.7 g/kg), followed by protein (320.0±1.4–352.5±1.0 g/kg). The predominant phytosterol was β-sitosterol (average 18,177.7±763.8 µg/kg oil), and the main vitamin E isomer was γ-tocopherol (average 1071.1±109.8 µg/kg oil). Phenolics reached an average of 0.34±0.05 mg gallic acid equivalents/g. Vitamin C and ORAC exhibited an average of 27.7±1.4 mg/kg and 8.54+0.03 µmol Trolox equivalents/g, respectively. Linoleic was the most abundant fatty acid, followed by oleic acid. The chemical composition of pine nuts harvested in different macrozones reveals good nutritional properties and potential health benefits.