This page has only limited features, please log in for full access.
Nanoporous Au is a model system extensively studied to investigate how porosity affects the mechanical behaviour. To fabricate nanoporous Au structures with similar ligament diameter, but different solid volume fractions, we applied tailored dealloying procedures to Ag-Au alloys with Au atomic fraction ranging from 0.20 to 0.41. Their Young’s moduli, measured by nanoindentation, correlate with the Au atomic fraction. The scaling law we observe suggests a crucial role of percolation thresholds in the definition of mechanical properties.
Paolo Barra; Francesco Delogu. Porosity effects on nanoporous Au Young’s modulus. Materials Letters 2021, 304, 130703 .
AMA StylePaolo Barra, Francesco Delogu. Porosity effects on nanoporous Au Young’s modulus. Materials Letters. 2021; 304 ():130703.
Chicago/Turabian StylePaolo Barra; Francesco Delogu. 2021. "Porosity effects on nanoporous Au Young’s modulus." Materials Letters 304, no. : 130703.
With its ability to enable solvent-free chemical reactions, mechanochemistry promises to open new and greener synthetic routes to chemical products of industrial interest.
Maria Carta; Francesco Delogu; Andrea Porcheddu. A phenomenological kinetic equation for mechanochemical reactions involving highly deformable molecular solids. Physical Chemistry Chemical Physics 2021, 23, 14178 -14194.
AMA StyleMaria Carta, Francesco Delogu, Andrea Porcheddu. A phenomenological kinetic equation for mechanochemical reactions involving highly deformable molecular solids. Physical Chemistry Chemical Physics. 2021; 23 (26):14178-14194.
Chicago/Turabian StyleMaria Carta; Francesco Delogu; Andrea Porcheddu. 2021. "A phenomenological kinetic equation for mechanochemical reactions involving highly deformable molecular solids." Physical Chemistry Chemical Physics 23, no. 26: 14178-14194.
This work focuses on the erodent capability of yttria-stabilized zirconia beads impacting on a limestone target surface. The target surface was used as the cap of a hardened steel vial clamped on a SPEX Mixer/Mill 8000. The vial three-dimensional swing results in repeated bead impacts that cause the material removal from the target surface. The mass loss varies linearly with the number of beads, which allowed estimating the mass lost per bead per impact. It amounts approximately to 70 ng, a value that compares fairly well with the one of about 80 ng estimated from the volume of the indents left on the target surface by individual impacts. Experimental findings indicate that the methodology developed can be reliably utilized to investigate solid particle erosion under highly reproducible and controllable experimental conditions.
Anna Laura Sanna; Giorgio Pia; Francesco Delogu. Solid Particle Erosion of a Limestone Target Surface under Controlled Conditions. Advances in Materials Science and Engineering 2020, 2020, 1 -8.
AMA StyleAnna Laura Sanna, Giorgio Pia, Francesco Delogu. Solid Particle Erosion of a Limestone Target Surface under Controlled Conditions. Advances in Materials Science and Engineering. 2020; 2020 ():1-8.
Chicago/Turabian StyleAnna Laura Sanna; Giorgio Pia; Francesco Delogu. 2020. "Solid Particle Erosion of a Limestone Target Surface under Controlled Conditions." Advances in Materials Science and Engineering 2020, no. : 1-8.
Co-deformation and forced mixing contribute to the rate of chemical reaction between molecular solids subjected to mechanical processing.
Gabriele Traversari; Andrea Porcheddu; Giorgio Pia; Francesco Delogu; Alberto Cincotti. Coupling of mechanical deformation and reaction in mechanochemical transformations. Physical Chemistry Chemical Physics 2020, 23, 229 -245.
AMA StyleGabriele Traversari, Andrea Porcheddu, Giorgio Pia, Francesco Delogu, Alberto Cincotti. Coupling of mechanical deformation and reaction in mechanochemical transformations. Physical Chemistry Chemical Physics. 2020; 23 (1):229-245.
Chicago/Turabian StyleGabriele Traversari; Andrea Porcheddu; Giorgio Pia; Francesco Delogu; Alberto Cincotti. 2020. "Coupling of mechanical deformation and reaction in mechanochemical transformations." Physical Chemistry Chemical Physics 23, no. 1: 229-245.
The mechanochemical preparation of silver sulfadiazine and dantrolene, two marketed active pharmaceutical ingredients, was investigated by in situ Raman spectroscopy. For the first time, the mechanochemical transformations involving highly fluorescent compounds could be studied in situ with a high-resolution Raman system combined with a unique suitable Raman probe. Moreover, the kinetic features of the mechanochemical process were examined by a mathematical model allowing to describe the chemical changes under mechanical stress. This approach is promising both to broaden the scope of Raman in situ investigations that would otherwise be impossible and for process optimization at any scale.
Irena Sović; Stipe Lukin; Ernest Meštrović; Ivan Halasz; Andrea Porcheddu; Francesco Delogu; Pier Carlo Ricci; Fabien Caron; Thomas Perilli; Anita Dogan; Evelina Colacino. Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy. ACS Omega 2020, 5, 28663 -28672.
AMA StyleIrena Sović, Stipe Lukin, Ernest Meštrović, Ivan Halasz, Andrea Porcheddu, Francesco Delogu, Pier Carlo Ricci, Fabien Caron, Thomas Perilli, Anita Dogan, Evelina Colacino. Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy. ACS Omega. 2020; 5 (44):28663-28672.
Chicago/Turabian StyleIrena Sović; Stipe Lukin; Ernest Meštrović; Ivan Halasz; Andrea Porcheddu; Francesco Delogu; Pier Carlo Ricci; Fabien Caron; Thomas Perilli; Anita Dogan; Evelina Colacino. 2020. "Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy." ACS Omega 5, no. 44: 28663-28672.
This work focuses on the propagation of mechanically activated self-sustaining reactions during the mechanical processing of powder in ball mills. We use a numerical model to reconstruct the dynamics of a single ball and powder particles inside the reactor of a SPEX Mixer/Mill 8000 under operational conditions. Taking advantage of the analytical description of the reactor swing, the equations of motion of ball and powder particles are solved numerically. The discrete element method is used to describe contacts. Reaction is ignited in an individual particle randomly selected among those compressed during an impact between ball and reactor. A simple kinetic law and a set of rules involving degree of chemical conversion and distance between particles are used to obtain a phenomenological description of the reaction propagation. We show that the propagation is significantly affected by reaction rate in individual particles, with other factors being less influential. We observe a strong coupling between the dynamics of powder particles and the reaction propagation.
Alberto Cincotti; Gabriele Traversari; Giorgio Pia; Francesco Delogu. Milling Dynamics and Propagation of Mechanically Activated Self-Sustaining Reactions. Advances in Materials Science and Engineering 2020, 2020, 1 -10.
AMA StyleAlberto Cincotti, Gabriele Traversari, Giorgio Pia, Francesco Delogu. Milling Dynamics and Propagation of Mechanically Activated Self-Sustaining Reactions. Advances in Materials Science and Engineering. 2020; 2020 ():1-10.
Chicago/Turabian StyleAlberto Cincotti; Gabriele Traversari; Giorgio Pia; Francesco Delogu. 2020. "Milling Dynamics and Propagation of Mechanically Activated Self-Sustaining Reactions." Advances in Materials Science and Engineering 2020, no. : 1-10.
Hydrogen (H2) absorption by metals, metal alloys, and more complex solids is a crucial issue on the road to the efficient H2 storage required by the hydrogen economy. The present study examines the reaction between Mg powder and gaseous H2 under ball milling conditions as a specific case study. Based on accurate kinetic evidence, we show that H2 absorption is governed by a combination of statistical and chemical contributions related, respectively, to the inherent nature of ball milling and the chemistry of the Mg–H2 system. The combination of the two factors determines the shape of the H2 absorption curve. Therefore, chemical information can be only obtained by disentangling the two contributions. To this aim, we propose a general method that can be extended to other chemical transformations activated by ball milling.
Andrea Porcheddu; Alberto Cincotti; Francesco Delogu. Kinetics of MgH2 formation by ball milling. International Journal of Hydrogen Energy 2020, 46, 967 -973.
AMA StyleAndrea Porcheddu, Alberto Cincotti, Francesco Delogu. Kinetics of MgH2 formation by ball milling. International Journal of Hydrogen Energy. 2020; 46 (1):967-973.
Chicago/Turabian StyleAndrea Porcheddu; Alberto Cincotti; Francesco Delogu. 2020. "Kinetics of MgH2 formation by ball milling." International Journal of Hydrogen Energy 46, no. 1: 967-973.
To help understanding the mechanisms underlying mechanochemical transformations, we propose a kinetic model that relates macroscopic and microscopic scales while accounting for the statistical nature of the mechanical processing of powder.
Maria Carta; Evelina Colacino; Francesco Delogu; Andrea Porcheddu. Kinetics of mechanochemical transformations. Physical Chemistry Chemical Physics 2020, 22, 14489 -14502.
AMA StyleMaria Carta, Evelina Colacino, Francesco Delogu, Andrea Porcheddu. Kinetics of mechanochemical transformations. Physical Chemistry Chemical Physics. 2020; 22 (26):14489-14502.
Chicago/Turabian StyleMaria Carta; Evelina Colacino; Francesco Delogu; Andrea Porcheddu. 2020. "Kinetics of mechanochemical transformations." Physical Chemistry Chemical Physics 22, no. 26: 14489-14502.
Environmental pollution, population increase, water availability and misuse of land are inexorably driving humans to take on important challenges related to sustainability. The next future is expected to see a significant increase of food and feed demands, which determines a serious threat to well-being levels and even survival of modern societies. Within this scenario, the efficient and sustainable use of insects as protein sources has been invoked as a possible strategic solution. As a candidate for remarkable growth, insect farming promises significant benefits to agri-food industry, offering interesting opportunities for implementing circular economy. In the present work, we review selected literature on insect rearing with the aim of providing a short rigorous introduction to the field to researchers, entrepreneurs and common readers. After a general overview of the field, including a description of insect nutritional values, the review focuses on the three insect species that are seemingly set to beneficially affect aquaculture, which is the activity presently more sensitive to circularity and sustainability innovation. Once traditional and advanced insect rearing methods are described, the challenges that the field is going to tackle are suitably highlighted.
Lorenzo A. Cadinu; Paolo Barra; Francesco Torre; Francesco Delogu; Fabio A. Madau. Insect Rearing: Potential, Challenges, and Circularity. Sustainability 2020, 12, 4567 .
AMA StyleLorenzo A. Cadinu, Paolo Barra, Francesco Torre, Francesco Delogu, Fabio A. Madau. Insect Rearing: Potential, Challenges, and Circularity. Sustainability. 2020; 12 (11):4567.
Chicago/Turabian StyleLorenzo A. Cadinu; Paolo Barra; Francesco Torre; Francesco Delogu; Fabio A. Madau. 2020. "Insect Rearing: Potential, Challenges, and Circularity." Sustainability 12, no. 11: 4567.
We focus on understanding the kinetics of a mechanically activated Knoevenagel condensation conducted in a ball mill, that is characterized by sigmoidal kinetics and the formation of a rubber-like cohesive intermediate state coating the milling ball. The previously described experimental findings are explained using a phenomenological kinetic model. It is assumed that reactants transform into products already at the very first collision of the ball with the wall of the jar. The portion of reactants that are transformed into products during each oscillation is taken to be a fraction of the amount of material that is trapped between the ball and the wall of the jar. This quantity is greater when the reaction mixture transforms from its initial powder form to the rubber-like cohesive coating on the ball. Further, the amount of reactants processed in each collision varies proportionally with the total area of the layer coating the ball. The total area of this coating layer is predicted to vary with the third power of time, thus accounting for the observed dramatic increase of the reaction rate. Supporting experiments, performed using a polyvinyl acetate adhesive as a nonreactive but cohesive material, confirm that the coating around the ball grows with the third power of time.
Maria Carta; Stuart L. James; Francesco Delogu. Phenomenological Inferences on the Kinetics of a Mechanically Activated Knoevenagel Condensation: Understanding the "Snowball" Kinetic Effect in Ball Milling. Molecules 2019, 24, 3600 .
AMA StyleMaria Carta, Stuart L. James, Francesco Delogu. Phenomenological Inferences on the Kinetics of a Mechanically Activated Knoevenagel Condensation: Understanding the "Snowball" Kinetic Effect in Ball Milling. Molecules. 2019; 24 (19):3600.
Chicago/Turabian StyleMaria Carta; Stuart L. James; Francesco Delogu. 2019. "Phenomenological Inferences on the Kinetics of a Mechanically Activated Knoevenagel Condensation: Understanding the "Snowball" Kinetic Effect in Ball Milling." Molecules 24, no. 19: 3600.
An environmentally-friendly mechanochemical strategy for the preparation of unsymmetrical ureas and 3,5-disubstituted hydantoins by using safe starting materials in place of hazardous and toxic isocyanates has been designed. For the first time, the Lossen rearrangement was successfully applied to prepare a collection of relevant structures in medicinal chemistry via a one-pot mechanochemical approach and without a single drop of organic solvent including during the work-up. The procedure was effective for the preparation of the Active Pharmaceutical Ingredient (API) Ethotoin.
Andrea Porcheddu; Francesco Delogu; Lidia De Luca; Evelina Colacino. From Lossen Transposition to Solventless “Medicinal Mechanochemistry”. ACS Sustainable Chemistry & Engineering 2019, 1 .
AMA StyleAndrea Porcheddu, Francesco Delogu, Lidia De Luca, Evelina Colacino. From Lossen Transposition to Solventless “Medicinal Mechanochemistry”. ACS Sustainable Chemistry & Engineering. 2019; ():1.
Chicago/Turabian StyleAndrea Porcheddu; Francesco Delogu; Lidia De Luca; Evelina Colacino. 2019. "From Lossen Transposition to Solventless “Medicinal Mechanochemistry”." ACS Sustainable Chemistry & Engineering , no. : 1.
The sustainable preparation of hydantoin-based Active Pharmaceutical Ingredients (APIs) using modern non-conventional activation methods, including mechanochemistry is herein described.
Evelina Colacino; Andrea Porcheddu; Clarence Charnay; Francesco Delogu. From enabling technologies to medicinal mechanochemistry: an eco-friendly access to hydantoin-based active pharmaceutical ingredients. Reaction Chemistry & Engineering 2019, 4, 1179 -1188.
AMA StyleEvelina Colacino, Andrea Porcheddu, Clarence Charnay, Francesco Delogu. From enabling technologies to medicinal mechanochemistry: an eco-friendly access to hydantoin-based active pharmaceutical ingredients. Reaction Chemistry & Engineering. 2019; 4 (7):1179-1188.
Chicago/Turabian StyleEvelina Colacino; Andrea Porcheddu; Clarence Charnay; Francesco Delogu. 2019. "From enabling technologies to medicinal mechanochemistry: an eco-friendly access to hydantoin-based active pharmaceutical ingredients." Reaction Chemistry & Engineering 4, no. 7: 1179-1188.
The present work focuses on the challenges that emerge in connection with the kinetics of mechanically activated transformations. This is an important topics to comprehend to enable the full exploitation of mechanical processing in a broad spectrum of areas related to chemistry and materials science and engineering. Emerging challenges involve a number of facets regarding materials and material properties, working principles of ball mills and milling conditions, and local changes occurring in series in processed materials. Within this context, it is highly desirable to relate the nature and rate of observed mechanochemical transformations to individual collisions and then to the processes induced by mechanical stresses on the molecular scale. Hence, it is necessary to characterize the milling regimes that can establish in ball mills regarding frequency and energy of collisions, map the relationship between milling dynamics and transformation kinetics, and obtain mechanistic information through proper time-resolved investigations in situ. A few specific hints are provided in this respect.
Evelina Colacino; Maria Carta; Giorgio Pia; Andrea Porcheddu; Pier Carlo Ricci; Francesco Delogu. Processing and Investigation Methods in Mechanochemical Kinetics. ACS Omega 2018, 3, 9196 -9209.
AMA StyleEvelina Colacino, Maria Carta, Giorgio Pia, Andrea Porcheddu, Pier Carlo Ricci, Francesco Delogu. Processing and Investigation Methods in Mechanochemical Kinetics. ACS Omega. 2018; 3 (8):9196-9209.
Chicago/Turabian StyleEvelina Colacino; Maria Carta; Giorgio Pia; Andrea Porcheddu; Pier Carlo Ricci; Francesco Delogu. 2018. "Processing and Investigation Methods in Mechanochemical Kinetics." ACS Omega 3, no. 8: 9196-9209.
The gram-scale mechanochemical preparation of marketed drugs Nitrofurantoin and Dantrolene is herein reported.
Evelina Colacino; Andrea Porcheddu; Ivan Halasz; Clarence Charnay; Francesco Delogu; Ruben Guerra; Julien Fullenwarth. Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene. Green Chemistry 2018, 20, 2973 -2977.
AMA StyleEvelina Colacino, Andrea Porcheddu, Ivan Halasz, Clarence Charnay, Francesco Delogu, Ruben Guerra, Julien Fullenwarth. Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene. Green Chemistry. 2018; 20 (13):2973-2977.
Chicago/Turabian StyleEvelina Colacino; Andrea Porcheddu; Ivan Halasz; Clarence Charnay; Francesco Delogu; Ruben Guerra; Julien Fullenwarth. 2018. "Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene." Green Chemistry 20, no. 13: 2973-2977.
This study concerns the elastic properties of nanoporous Au exposed to dry and humid air. The variation of relative humidity induces a strain connected with the water adsorption on the nanoporous Au surface. The strain behavior allows estimating the change in surface stress. We show that the strain behavior affects the effective Young’s modulus of nanoporous Au and that the effect depends on the ligament size.
Giorgio Pia; Maria Carta; Francesco Delogu. Stiffening of nanoporous Au induced by water physisorption. Materials Letters 2018, 220, 116 -118.
AMA StyleGiorgio Pia, Maria Carta, Francesco Delogu. Stiffening of nanoporous Au induced by water physisorption. Materials Letters. 2018; 220 ():116-118.
Chicago/Turabian StyleGiorgio Pia; Maria Carta; Francesco Delogu. 2018. "Stiffening of nanoporous Au induced by water physisorption." Materials Letters 220, no. : 116-118.
This work focuses on the effects of ligament size on the mechanical behavior of NP Au foams. NP Au structures with ligament diameter between 5 and 200 nm have been fabricated by selective Ag dissolution from Ag70Au30alloys prepared by mechanical alloying and subsequent annealing. Nanoindentation experiments indicate that the effective Young's modulus increases as the ligament thickness decreases. The stiffening of NP Au foams with fine ligaments is ascribed to size effects connected with surface stress states. It is shown that a phenomenological model accounting for disorder and surface contributions to Young's modulus correctly predicts the observed behavior
Giorgio Pia; Maria Carta; Francesco Delogu. Nanoporous Au foams: Variation of effective Young's modulus with ligament size. Scripta Materialia 2018, 144, 22 -26.
AMA StyleGiorgio Pia, Maria Carta, Francesco Delogu. Nanoporous Au foams: Variation of effective Young's modulus with ligament size. Scripta Materialia. 2018; 144 ():22-26.
Chicago/Turabian StyleGiorgio Pia; Maria Carta; Francesco Delogu. 2018. "Nanoporous Au foams: Variation of effective Young's modulus with ligament size." Scripta Materialia 144, no. : 22-26.
Mechanochemical “parallel synthesis”: processing 12 samples simultaneously allowed fast screening of the optimum reaction conditions and high throughput preparation of benzozaxine derivatives, including a fungicide.
Katia Martina; Laura Rotolo; Andrea Porcheddu; Francesco Delogu; S. R. Bysouth; Giancarlo Cravotto; Evelina Colacino. High throughput mechanochemistry: application to parallel synthesis of benzoxazines. Chemical Communications 2017, 54, 551 -554.
AMA StyleKatia Martina, Laura Rotolo, Andrea Porcheddu, Francesco Delogu, S. R. Bysouth, Giancarlo Cravotto, Evelina Colacino. High throughput mechanochemistry: application to parallel synthesis of benzoxazines. Chemical Communications. 2017; 54 (5):551-554.
Chicago/Turabian StyleKatia Martina; Laura Rotolo; Andrea Porcheddu; Francesco Delogu; S. R. Bysouth; Giancarlo Cravotto; Evelina Colacino. 2017. "High throughput mechanochemistry: application to parallel synthesis of benzoxazines." Chemical Communications 54, no. 5: 551-554.
A very efficient mechanically activated synthesis of isocyanides directly from primary amines and without extra-solvent addition has been reported.
Rita Mocci; Sergio Murgia; Lidia De Luca; Evelina Colacino; Francesco Delogu; Andrea Porcheddu. Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction. Organic Chemistry Frontiers 2017, 5, 531 -538.
AMA StyleRita Mocci, Sergio Murgia, Lidia De Luca, Evelina Colacino, Francesco Delogu, Andrea Porcheddu. Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction. Organic Chemistry Frontiers. 2017; 5 (4):531-538.
Chicago/Turabian StyleRita Mocci; Sergio Murgia; Lidia De Luca; Evelina Colacino; Francesco Delogu; Andrea Porcheddu. 2017. "Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction." Organic Chemistry Frontiers 5, no. 4: 531-538.
The present study concerns the mechanical behavior of nanoporous Au foams alternately exposed to gaseous ozone and carbon dioxide. The periodic atmosphere variation is known to induce reversible macroscopic strain in nanoporous Au consequent to the corresponding cycles of surface oxidation and reduction. Here, we show that strain cycling is also accompanied by a progressive hardening of the nanoporous Au foam
Giorgio Pia; Francesco Delogu. Hardening of nanoporous Au foams induced by surface chemistry. Materials Letters 2017, 196, 332 -334.
AMA StyleGiorgio Pia, Francesco Delogu. Hardening of nanoporous Au foams induced by surface chemistry. Materials Letters. 2017; 196 ():332-334.
Chicago/Turabian StyleGiorgio Pia; Francesco Delogu. 2017. "Hardening of nanoporous Au foams induced by surface chemistry." Materials Letters 196, no. : 332-334.
This study focuses on the structural stability of nanoporous Au foams fabricated by chemical dealloying. Thermal annealing and catalytic transformations are shown to activate coarsening processes exhibiting same overall kinetics and comparable rate. Data support the hypothesis of a mechanistic scenario dominated by surface diffusion and suggest for catalytic runs local temperatures higher than nominal ones.
Giorgio Pia; Alberto Cincotti; Francesco Delogu. Thermally and catalytically induced coarsening of nanoporous Au. Materials Letters 2016, 183, 114 -116.
AMA StyleGiorgio Pia, Alberto Cincotti, Francesco Delogu. Thermally and catalytically induced coarsening of nanoporous Au. Materials Letters. 2016; 183 ():114-116.
Chicago/Turabian StyleGiorgio Pia; Alberto Cincotti; Francesco Delogu. 2016. "Thermally and catalytically induced coarsening of nanoporous Au." Materials Letters 183, no. : 114-116.