Dr. Simona Mrakic-Sposta
National Research Council - Institute of Clinical Physiology (CNR-IFC), Milan, Italy;
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Academic Career Length
21Years (2006-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications12 August 2008 in Neurology
Journal Article
Roberta FerrucciFMFrancesca Mameli
Francesca MameliIGI. Guidi
I. Guidi
Simona Mrakic-Sposta
Maurizio Vergari
Alberto Priori +4
Objective: To evaluate the cognitive effect of transcranial direct current stimulation (tDCS) over the temporoparietal areas in patients with Alzheimer disease (AD). Methods: In 10 patients with probable AD, we delivered anodal tDCS (AtDCS), cathodal tDCS (CtDCS), and sham tDCS (StDCS) over the temporoparietal areas in three sessions. In each session recognition memory and visual attention were tested at baseline (prestimulation) and 30 minutes after tDCS ended (poststimulation). Results: After AtDCS, accuracy of the word recognition memory task increased (prestimulation: 15.5 ± 0.9, poststimulation: 17.9 ± 0.8, p = 0.0068) whereas after CtDCS it decreased (15.8 ± 0.6 vs 13.2 ± 0.9, p = 0.011) and after StDCS it remained unchanged (16.3 ± 0.7 vs 16.0 ± 1.0, p = 0.75). tDCS left the visual attention-reaction times unchanged. Conclusion: Transcranial direct current stimulation (tDCS) delivered over the temporoparietal areas can specifically affect a recognition memory performance in patients with Alzheimer disease (AD). Because tDCS is simple, safe and inexpensive, our finding prompts studies using repeated tDCS, in conjunction with other therapeutic interventions for treating patients with AD.
1 April 2008 in Journal of Neurology, Neurosurgery & Psychiatry
Journal Article
AMA Monti
A Monti
FCF Cogiamanian
F Cogiamanian
SMSara Marceglia
Sara MarcegliaRoberta FerrucciFMFrancesca Mameli
Francesca MameliAlberto Priori +3
Transcranial direct current stimulation (tDCS) has been proposed as an adjuvant technique to improve functional recovery after ischaemic stroke. This study evaluated the effect of tDCS over the left frontotemporal areas in eight chronic non-fluent post-stroke aphasic patients. The protocol consisted of the assessment of picture naming (accuracy and response time) before and immediately after anodal or cathodal tDCS (2 mA, 10 minutes) and sham stimulation. Whereas anodal tDCS and sham tDCS failed to induce any changes, cathodal tDCS significantly improved the accuracy of the picture naming task by a mean of 33.6% (SEM 13.8%).
1 September 2008 in Journal of Cognitive Neuroscience
Journal Article
Roberta FerrucciSMSara Marceglia
Sara MarcegliaMaurizio VergariFCF. Cogiamanian
F. Cogiamanian
Simona Mrakic-SpostaAlberto Priori +3
How the cerebellum is involved in the practice and proficiency of non-motor functions is still unclear. We tested whether transcranial direct current stimulation (tDCS) over the cerebellum (cerebellar tDCS) induces after-effects on the practice-dependent increase in the proficiency of a working memory (WM) task (Sternberg test) in 13 healthy subjects. We also assessed the effects of cerebellar tDCS on visual evoked potentials (VEPs) in four subjects and compared the effects of cerebellar tDCS on the Sternberg test with those elicited by tDCS delivered over the prefrontal cortex in five subjects. Our experiments showed that anodal or cathodal tDCS over the cerebellum impaired the practice-dependent improvement in the reaction times in a WM task. Because tDCS delivered over the prefrontal cortex induced an immediate change in the WM task but left the practice-dependent proficiency unchanged, the effects of cerebellar tDCS are structure-specific. Cerebellar tDCS left VEPs unaffected, its effect on the Sternberg task therefore seems unlikely to arise from visual system involvement. In conclusion, tDCS over the cerebellum specifically impairs the practice-dependent proficiency increase in verbal WM.
1 November 2010 in Experimental Neurology
Journal Article
GGGaia Giannicola
Gaia Giannicola
SMSara Marceglia
Sara MarcegliaLRLorenzo Rossi
Lorenzo Rossi
Simona Mrakic-SpostaPRPaolo Rampini
Paolo Rampini
Alberto Priori +3
30 August 2009 in Cognitive Processing
Journal Article
MFM. Fumagalli
M. Fumagalli
Roberta FerrucciFMFrancesca Mameli
Francesca MameliSMSara Marceglia
Sara MarcegliaSimona Mrakic-SpostaAlberto Priori +6
21 June 2007 in Cerebral Cortex
Journal Article
Alberto PrioriFMFrancesca Mameli
Francesca MameliFCF. Cogiamanian
F. Cogiamanian
SMSara Marceglia
Sara MarcegliaMTM. Tiriticco
M. Tiriticco
GSGiuseppe Sartori
Giuseppe Sartori +4
Lies are intentional distortions of event knowledge. No experimental data are available on manipulating lying processes. To address this issue, we stimulated the dorsolateral prefrontal cortex (DLPFC) using transcranial direct current stimulation (tDCS). Fifteen healthy volunteers were tested before and after tDCS (anodal, cathodal, and sham). Two types of truthful (truthful selected: TS; truthful unselected: TU) and deceptive (lie selected: LS; lie unselected: LU) responses were evaluated using a computer-controlled task. Reaction times (RTs) and accuracy were collected and used as dependent variables. In the baseline task, the RT was significantly longer for lie responses than for true responses ([mean ± standard error] 1153.4 ± 42.0 ms vs. 1039.6 ± 36.6 ms; F1,14 = 27.25, P = 0.00013). At baseline, RT for selected pictures was significantly shorter than RT for unselected pictures (1051.26 ± 39.0 ms vs. 1141.76 ± 41.1 ms; F1,14 = 34.85, P = 0.00004). Whereas after cathodal and sham stimulation, lie responses remained unchanged (cathodal 5.26 ± 2.7%; sham 5.66 ± 3.6%), after anodal tDCS, RTs significantly increased but did so only for LS responses (16.86 ± 5.0%; P = 0.002). These findings show that manipulation of brain function with DLPFC tDCS specifically influences experimental deception and that distinctive neural mechanisms underlie different types of lies.
About Me
Prof. Simona MRAKIC-SPOSTA is a Researcher at the Institute of Clinical Physiology, Italian National Research Council, with a Ph.D. in Molecular Medicine. From 2017, she is a contract Professor in “Human Anatomy and Histology” in Roma. She is qualified as an Associate Professor N6/01. She is the Secretary of the Italian Society of Mountain Medicine, SIMeM from October 2017. In 2016 and 2022, she won the prize for the Best Oral Communication from the Società Italiana Medicina di Montagna, and in 2022, the prize for Best Poster and Oral Communication from the Società Italiana Medicina Subacquea. Simona's research fields include oxidative stress, inflammation, and organ damage in physiological/pathological conditions and/or during/after dietary supplementation or specific diet. Part of her research has focused on the physiological adaptation of the whole body to extreme/environmental conditions (high altitude, hypobaric and normobaric hypoxia, hyperoxia) with or without adaptation to exercise. She also focuses on muscle atrophy/the aging process/neurodegeneration. She is also interested in the assessment of Reactive Oxygen Species (ROS) production and antioxidant capacity in biological samples (blood/saliva/urine/cell/tissues: in vivo and in vitro by humans and animals) by Electron Paramagnetic Resonance. She continues to study the effects of non-invasive cortical stimulation in neurological/neurodegenerative disorders.