A dual network hydrogel based on Schiff base bonding and electrostatic interaction was prepared. The hydrogel is non-toxic, self-healing and injectable. And it has great drug release control, adjusting release rate via SA at different pH levels.

In the R22 (chlorodifuoromethane) steam-cracking process, which is used to produce a TFE (tetrafluoroethylene) monomer, distillation is employed to separate the high-purity TFE monomer from the cracked gas generated during this procedure. Traditionally, this distillation process is carried out using five towers. In this study, the traditional five-tower distillation method was transformed into a four-tower distillation method through the Aspen Plus simulation software, and this process was simulated and optimized. Meanwhile, a double-effect distillation process was designed for the transformed four-tower distillation process. The transformed distillation process not only meets the requirements of 99.999% purity for the TFE monomer and 99.99% purity for R22 recycling, but it also reduces the footprint by eliminating one distillation tower and saves 112.9002 kW of tower load, thus reducing the operating costs. This research provides valuable guidance for practical production.

In this work, the modified attachment energy model was used to predict the crystal morphology of isosorbide mononitrate (ISMN) in the dichloromethane (CH₂Cl₂) solvent system and dichloromethane-n-hexane (CH₂Cl₂-C₆H₁₄) mixed solvent system. The solvent effect can significantly affect the crystal morphology, which can profoundly impact both the drug’s physicochemical properties and the subsequent technological treatment process. In addition, the interactions between solvent molecules and crystal faces were investigated using molecular dynamics simulation, and radial distribution function (RDF) analysis was performed to determine the types of interactions. The structural parameter S was introduced to characterize the roughness of each crystal surface; the change in the CH₂Cl₂ diffusion coefficient before and after the addition of C₆H₁₄ was analyzed using mean square displacement (MSD). The calculation results of the modified attachment energy from the two solvent systems revealed that C₆H₁₄ could accelerate crystal growth, while the crystal morphology was not greatly affected, which is of some significance as a guide for the industrial crystallization process.