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The current SARS-CoV-2 disease (COVID-19) pandemic is a sudden major stressor superimposed on pre-existing high distress in parents of infants admitted to the neonatal intensive care unit (NICU). This study aimed to investigate the psychological wellbeing of NICU parents during the COVID-19 pandemic. Forty-four parents of 25 inpatients of the Padua University Hospital NICU were included from June 2020 to February 2021. At 7–14 days postpartum parents completed the Edinburgh Postnatal Depression Scale (EPDS), State-Trait Anxiety Inventory (STAI), Parental Stressor Scale: NICU (PSS:NICU) and an ad-hoc questionnaire measuring parental COVID-19 related stress. About one third of parents reported extreme/high stress and a relevant negative impact on parenthood experience. Less time (82%) and less physical contact (73%) with infants due to COVID-19 preventive measures were the most frequent negative factors. Higher COVID-19 related parental stress was positively associated with anxiety, depression, NICU parental stress, stress related to NICU environment, and parental role alterations. Depression symptoms, stress related to infant condition and parental role alterations were higher in mothers. The pandemic affected parental emotional and relational wellbeing directly through additional stress due to COVID-19 concerns and indirectly through the impact of restrictions on the experience of becoming parents.
Laura Polloni; Francesco Cavallin; Elisabetta Lolli; Rossana Schiavo; Martina Bua; Biancarosa Volpe; Marta Meneghelli; Eugenio Baraldi; Daniele Trevisanuto. Psychological Wellbeing of Parents with Infants Admitted to the Neonatal Intensive Care Unit during SARS-CoV-2 Pandemic. Children 2021, 8, 755 .
AMA StyleLaura Polloni, Francesco Cavallin, Elisabetta Lolli, Rossana Schiavo, Martina Bua, Biancarosa Volpe, Marta Meneghelli, Eugenio Baraldi, Daniele Trevisanuto. Psychological Wellbeing of Parents with Infants Admitted to the Neonatal Intensive Care Unit during SARS-CoV-2 Pandemic. Children. 2021; 8 (9):755.
Chicago/Turabian StyleLaura Polloni; Francesco Cavallin; Elisabetta Lolli; Rossana Schiavo; Martina Bua; Biancarosa Volpe; Marta Meneghelli; Eugenio Baraldi; Daniele Trevisanuto. 2021. "Psychological Wellbeing of Parents with Infants Admitted to the Neonatal Intensive Care Unit during SARS-CoV-2 Pandemic." Children 8, no. 9: 755.
Acral melanoma (AM) is a rare and aggressive subtype of melanoma affecting the palms, soles, and nail apparatus with similar incidence among different ethnicities. AM is unrelated to ultraviolet radiation and has a low mutation burden but frequent chromosomal rearrangements and gene amplifications. Next generation sequencing of 33 genes and somatic copy number variation (CNV) analysis with genome-wide single nucleotide polymorphism arrays were performed in order to molecularly characterize 48 primary AMs of Italian patients in association with clinicopathological and prognostic features. BRAF was the most commonly mutated gene, followed by NRAS and TP53, whereas TERT promoter, KIT, and ARID1A were less frequently mutated. Gains and losses were recurrently found in the 1q, 6p, 7, 8q, 20 and 22 chromosomes involving PREX2, RAC1, KMT2C, BRAF, CCND1, TERT, and AKT3 genes, and in the 6q, 9, 10, 11q and 16q chromosomes including CDKN2A, PTEN, and ADAMTS18 genes, respectively. This study confirmed the variety of gene mutations and the high load of CNV in primary AM. Some genomic alterations were associated with histologic prognostic features. BRAF mutations, found with a higher rate than previously reported, correlated with a low Breslow thickness, low mitotic count, low CNV of the AMs, and with early-stage of disease.
Lisa Elefanti; Carolina Zamuner; Paolo Del Fiore; Camilla Stagni; Stefania Pellegrini; Luigi Dall’Olmo; Alessio Fabozzi; Rebecca Senetta; Simone Ribero; Roberto Salmaso; Simone Mocellin; Franco Bassetto; Francesco Cavallin; Anna Tosi; Francesca Galuppini; Angelo Dei Tos; Chiara Menin; Rocco Cappellesso. The Molecular Landscape of Primary Acral Melanoma: A Multicenter Study of the Italian Melanoma Intergroup (IMI). International Journal of Molecular Sciences 2021, 22, 3826 .
AMA StyleLisa Elefanti, Carolina Zamuner, Paolo Del Fiore, Camilla Stagni, Stefania Pellegrini, Luigi Dall’Olmo, Alessio Fabozzi, Rebecca Senetta, Simone Ribero, Roberto Salmaso, Simone Mocellin, Franco Bassetto, Francesco Cavallin, Anna Tosi, Francesca Galuppini, Angelo Dei Tos, Chiara Menin, Rocco Cappellesso. The Molecular Landscape of Primary Acral Melanoma: A Multicenter Study of the Italian Melanoma Intergroup (IMI). International Journal of Molecular Sciences. 2021; 22 (8):3826.
Chicago/Turabian StyleLisa Elefanti; Carolina Zamuner; Paolo Del Fiore; Camilla Stagni; Stefania Pellegrini; Luigi Dall’Olmo; Alessio Fabozzi; Rebecca Senetta; Simone Ribero; Roberto Salmaso; Simone Mocellin; Franco Bassetto; Francesco Cavallin; Anna Tosi; Francesca Galuppini; Angelo Dei Tos; Chiara Menin; Rocco Cappellesso. 2021. "The Molecular Landscape of Primary Acral Melanoma: A Multicenter Study of the Italian Melanoma Intergroup (IMI)." International Journal of Molecular Sciences 22, no. 8: 3826.
Meconium aspiration syndrome is a clinical condition characterized by respiratory failure occurring in neonates born through meconium-stained amniotic fluid. Worldwide, the incidence has declined in developed countries thanks to improved obstetric practices and perinatal care while challenges persist in developing countries. Despite the improved survival rate over the last decades, long-term morbidity among survivors remains a major concern. Since the 1960s, relevant changes have occurred in the perinatal and postnatal management of such patients but the most appropriate approach is still a matter of debate. This review offers an updated overview of the epidemiology, etiopathogenesis, diagnosis, management and prognosis of infants with meconium aspiration syndrome.
Chiara Monfredini; Francesco Cavallin; Paolo Villani; Giuseppe Paterlini; Benedetta Allais; Daniele Trevisanuto. Meconium Aspiration Syndrome: A Narrative Review. Children 2021, 8, 230 .
AMA StyleChiara Monfredini, Francesco Cavallin, Paolo Villani, Giuseppe Paterlini, Benedetta Allais, Daniele Trevisanuto. Meconium Aspiration Syndrome: A Narrative Review. Children. 2021; 8 (3):230.
Chicago/Turabian StyleChiara Monfredini; Francesco Cavallin; Paolo Villani; Giuseppe Paterlini; Benedetta Allais; Daniele Trevisanuto. 2021. "Meconium Aspiration Syndrome: A Narrative Review." Children 8, no. 3: 230.
Bone overheating is a possible cause of implants early failure. When a surgical guide is used, the risk of heat injury is greater due to the reduced efficacy of the irrigation. The aim of this ex vivo study was to evaluate the effect of an additional built-in irrigation on bone temperature variation during implant osteotomy. Twelve bovine ribs were used. Cone beam computerized tomography (CBCT) was performed and a 3D-printed surgical guide with additional built-in irrigation tubes was produced for each rib. A total of 48 osteotomies were prepared, to compare the supplementary internal irrigation system (Group A) with external irrigation alone (Group B), no irrigation (Group C) and with free-hand surgery with external irrigation (Group D). Temperature was measured by three thermocouples placed at depths of 1.5, 7, and 12 mm. The largest temperature variation at each thermocouple showed median values of 3.0 °C, 1.9 °C, and 2.3 °C in Group 1; 2.3 °C, 1.7 °C, and 0.9 °C in Group 2; 3.2 °C, 1.6 °C, and 2.0 °C in Group 3; 2.0 °C, 2.0 °C, and 1.3 °C in Group 4, respectively. No differences were found among the four groups. In general, the highest temperature increase was observed with the use of the first drill (cortical perforator). Post-experimental CBCT revealed the presence of radiopaque material clogging the aperture of the internal irrigation channels. Additional internal irrigation was not found to significantly contribute to decrease bone temperature in this ex vivo setting.
Michele Stocchero; Stefano Sivolella; Giulia Brunello; Arianna Zoppello; Francesco Cavallin; Lisa Biasetto. Bone Temperature Variation Using a 3D-Printed Surgical Guide with Internal Irrigation. Applied Sciences 2021, 11, 2588 .
AMA StyleMichele Stocchero, Stefano Sivolella, Giulia Brunello, Arianna Zoppello, Francesco Cavallin, Lisa Biasetto. Bone Temperature Variation Using a 3D-Printed Surgical Guide with Internal Irrigation. Applied Sciences. 2021; 11 (6):2588.
Chicago/Turabian StyleMichele Stocchero; Stefano Sivolella; Giulia Brunello; Arianna Zoppello; Francesco Cavallin; Lisa Biasetto. 2021. "Bone Temperature Variation Using a 3D-Printed Surgical Guide with Internal Irrigation." Applied Sciences 11, no. 6: 2588.
Although maternal antenatal transfer is the preferred option, some infants inevitably need urgent transport to a tertiary neonatal care facility after birth. This study aimed to investigate trends over time in patient characteristics and respiratory management in a large series of neonatal emergency transfers, in order to provide health caregivers an up-to-date profile of such patients and their therapeutic needs. Trends in patient characteristics and respiratory management were evaluated in 3337 transfers by the Eastern Veneto Neonatal Emergency Transport Service in 2000–2019. Joinpoint regression analysis was performed to evaluate trends and to estimate annual percentage changes (APCs). Proportions of preterm neonates increased (APC2000–2012 2.25%), then decreased (APC2012–2019 − 6.04%). Transfers at birth increased (APC2000–2013 2.69%), then decreased (APC2013–2019 − 5.76%). Proportion of neonates with cardiac and surgical diseases declined (APCs2000–2019 − 6.82% and − 3.32%), while proportion of neonates with neurologic diseases increased (APC2000–2019 8.62%). Use of nasal-continuous-positive-airway-pressure (APC2000–2019 9.72%) and high-flow-nasal-cannula (APC2007–2019 58.51%) at call, and nasal-continuous-positive-airway-pressure (APC2000–2019 13.87%) and nasal-intermittent-mandatory-ventilation (APC2000–2019 32.46%) during transfer increased. Mechanical ventilation during transfer decreased (APC2014–2019 − 10.77%). Use of oxygen concentrations at 21% increased at call and during transfer (APCs 2000–2019 2.24% and 2.44%), while oxygen concentrations above 40% decreased at call and during transfer (APCs 2000–2019 − 3.93% and − 5.12%). Conclusion: Our findings revealed a shift toward a more “gentle” approach and the reduced use of oxygen in respiratory management. Equipment and team expertise should meet the requirements of such changing patients and their therapeutic needs.
Daniele Trevisanuto; on behalf of the Servizio Trasporto Emergenza Neonatale STEN Group; Francesco Cavallin; Cristina Loddo; Laura Brombin; Elisabetta Lolli; Nicoletta Doglioni; Eugenio Baraldi. Trends in neonatal emergency transport in the last two decades. European Journal of Nuclear Medicine and Molecular Imaging 2021, 180, 635 -641.
AMA StyleDaniele Trevisanuto, on behalf of the Servizio Trasporto Emergenza Neonatale STEN Group, Francesco Cavallin, Cristina Loddo, Laura Brombin, Elisabetta Lolli, Nicoletta Doglioni, Eugenio Baraldi. Trends in neonatal emergency transport in the last two decades. European Journal of Nuclear Medicine and Molecular Imaging. 2021; 180 (2):635-641.
Chicago/Turabian StyleDaniele Trevisanuto; on behalf of the Servizio Trasporto Emergenza Neonatale STEN Group; Francesco Cavallin; Cristina Loddo; Laura Brombin; Elisabetta Lolli; Nicoletta Doglioni; Eugenio Baraldi. 2021. "Trends in neonatal emergency transport in the last two decades." European Journal of Nuclear Medicine and Molecular Imaging 180, no. 2: 635-641.
Background: DNA mismatch repair (MMR) is a system for repairing errors in DNA replication. Cancer cells with MMR deficiency can have immunohistochemical loss of MMR protein expression leading to a hypermutable phenotype that may correlate with anti-PD1 efficacy. Scant data exist about immunohistochemical loss of MMR protein expression in high-grade gliomas (HGG). Materials and Methods: We performed a large multicenter retrospective study to investigate the frequency and the prognostic role of immunohistochemical loss of MMR protein expression in HGG patients; we nevertheless evaluated the association between this status and clinical or molecular characteristics. Immunohistochemical loss of MMR protein expression was recorded as partial or complete loss of at least 1 MMR protein. Results: We analyzed the expression of MMR proteins in tumor tissue of 355 consecutive patients. Partial and complete immunohistochemical loss of MMR proteins was found in 43/355 samples (12.1%) and among these, 15 cases (4.2%) showed a complete loss of at the least one MMR protein. Alteration of MSH2 expression was found in 55.8%, MSH6 in 46.5%, PMS2 in 34.9%, and MLH1 in 30.2%. Alteration of MMR protein expression was statistically more frequent in anaplastic gliomas, in recurrent disease, in patients treated with temozolomide, and in IDH-mut gliomas. Immunohistochemical loss of MMR proteins was not associated with survival, adjusting for clinically relevant confounders. Conclusions: MMR protein expression status did not affect survival in HGG patients. We identified clinical and molecular characteristics correlating with immunohistochemical loss of MMR proteins expression. A large study should be performed to analyze its predictive role of immune checkpoint inhibitor efficacy in these subgroups of patients.
Mario Caccese; Tamara Ius; Matteo Simonelli; Matteo Fassan; Daniela Cesselli; Angelo DiPasquale; Francesco Cavallin; Marta Padovan; Alessandro Salvalaggio; Marina Paola Gardiman; Miran Skrap; Vittorina Zagonel; Giuseppe Lombardi. Mismatch-Repair Protein Expression in High-Grade Gliomas: A Large Retrospective Multicenter Study. International Journal of Molecular Sciences 2020, 21, 6716 .
AMA StyleMario Caccese, Tamara Ius, Matteo Simonelli, Matteo Fassan, Daniela Cesselli, Angelo DiPasquale, Francesco Cavallin, Marta Padovan, Alessandro Salvalaggio, Marina Paola Gardiman, Miran Skrap, Vittorina Zagonel, Giuseppe Lombardi. Mismatch-Repair Protein Expression in High-Grade Gliomas: A Large Retrospective Multicenter Study. International Journal of Molecular Sciences. 2020; 21 (18):6716.
Chicago/Turabian StyleMario Caccese; Tamara Ius; Matteo Simonelli; Matteo Fassan; Daniela Cesselli; Angelo DiPasquale; Francesco Cavallin; Marta Padovan; Alessandro Salvalaggio; Marina Paola Gardiman; Miran Skrap; Vittorina Zagonel; Giuseppe Lombardi. 2020. "Mismatch-Repair Protein Expression in High-Grade Gliomas: A Large Retrospective Multicenter Study." International Journal of Molecular Sciences 21, no. 18: 6716.
Introduction: Nasal septum deviation (NSD) is the most common structural cause of nasal obstruction, affecting around 65-80% of the adult population. Rapid maxillary expansion (RME) is currently used for treatment of maxillary transverse deficiency, but can also influence nasal cavity geometry. Objective: The present study aimed at evaluating the changes in NSD by using Cone-Beam Computed Tomography (CBCT) scans in pre-pubertal patients treated with RME. Methods: This retrospective exploratory study evaluated 20 pre-pubertal patients (mean age 10 ± 2 years) who were treated for transverse maxillary constriction with RME and presented mild/moderate NSD as an incidental finding. The outcome measures were NSD tortuosity and area. These measures were obtained from transverse and coronal views of records taken before and after RME treatment. Intra-rater reliability was also assessed with intraclass correlation coefficient. Results: NSD was mild in thirteen patients (65%) and moderate in seven (35%). NSD tortuosity index did not significantly change over time (mean difference 0.002 mm/year, 95% CI; p = 0.58). NSD area did not significantly change over time (mean difference 2.103 mm2/year, 95% CI; p = 0.38). Intraclass correlation coefficient was 0.73 (95% CI) for NSD tortuosity and 0.84 (95% CI) for NSD area. Conclusions: NSD tortuosity and area suggested potential changes in NSD with small clinical relevance in pre-pubertal patients who were treated with RME. Additional studies using CBCT scans in larger samples are required to clarify the role of RME in NSD treatment.
Giovanni Bruno; Alberto De Stefani; Celeste Benetazzo; Francesco Cavallin; Antonio Gracco. Changes in nasal septum morphology after rapid maxillary expansion: a Cone-Beam Computed Tomography study in pre-pubertal patient. Dental Press Journal of Orthodontics 2020, 25, 51 -56.
AMA StyleGiovanni Bruno, Alberto De Stefani, Celeste Benetazzo, Francesco Cavallin, Antonio Gracco. Changes in nasal septum morphology after rapid maxillary expansion: a Cone-Beam Computed Tomography study in pre-pubertal patient. Dental Press Journal of Orthodontics. 2020; 25 (5):51-56.
Chicago/Turabian StyleGiovanni Bruno; Alberto De Stefani; Celeste Benetazzo; Francesco Cavallin; Antonio Gracco. 2020. "Changes in nasal septum morphology after rapid maxillary expansion: a Cone-Beam Computed Tomography study in pre-pubertal patient." Dental Press Journal of Orthodontics 25, no. 5: 51-56.
Tracheal suctioning in non-vigorous newborn delivered through meconium-stained amniotic fluid (MSAF) is supposed to delay initiation of positive pressure ventilation (PPV), but the magnitude of such delay is unknown. To compare the time of PPV initiation when performing immediate laryngoscopy with intubation and suctioning vs. performing immediate PPV without intubation in a manikin model. Randomized controlled crossover (AB/BA) trial comparing PPV initiation with or without endotracheal suctioning in a manikin model of non-vigorous neonates born through MSAF. Participants were 20 neonatologists and 20 pediatric residents trained in advanced airway management. Timing of PPV initiation was longer with vs. without endotracheal suctioning in both pediatric residents (mean difference 13 s, 95% confidence interval 8 to 18 s; p < 0.0001) and neonatologists (mean difference 12 s, 95% confidence interval 8 to 16 s; p < 0.0001). The difference in timing of PPV initiation was similar between pediatric residents and neonatologists (mean difference − 1 s, 95% confidence interval − 7 to 6 s; p = 0.85).Conclusions: Performing immediate laryngoscopy with intubation and suctioning was associated with longer—but not clinically relevant—time of initiation of PPV compared with immediate PPV without intubation in a manikin model. While suggesting negligible delay in starting PPV, further studies in a clinical setting are warranted.Registration: clinicaltrial.gov NCT04076189. What is Known:• Management of the non-vigorous newborn delivered through meconium-stained amniotic fluid remains still controversial.• Tracheal suctioning in non-vigorous newborn delivered through meconium-stained amniotic fluid is supposed to delay initiation of positive pressure ventilation, but the magnitude of such delay is unknown.What is New:• Performing immediate ventilation without intubation was associated with shorter—but not clinically relevant—time of initiation of ventilation compared to immediate laryngoscopy with intubation and suctioning in a manikin model.• Further studies in a clinical setting are warranted.
Francesco Cavallin; Giulia Res; Chiara Monfredini; Nicoletta Doglioni; Paolo Ernesto Villani; Gary Weiner; Daniele Trevisanuto. Time needed to intubate and suction a manikin prior to instituting positive pressure ventilation: a simulation trial. European Journal of Pediatrics 2020, 180, 247 -252.
AMA StyleFrancesco Cavallin, Giulia Res, Chiara Monfredini, Nicoletta Doglioni, Paolo Ernesto Villani, Gary Weiner, Daniele Trevisanuto. Time needed to intubate and suction a manikin prior to instituting positive pressure ventilation: a simulation trial. European Journal of Pediatrics. 2020; 180 (1):247-252.
Chicago/Turabian StyleFrancesco Cavallin; Giulia Res; Chiara Monfredini; Nicoletta Doglioni; Paolo Ernesto Villani; Gary Weiner; Daniele Trevisanuto. 2020. "Time needed to intubate and suction a manikin prior to instituting positive pressure ventilation: a simulation trial." European Journal of Pediatrics 180, no. 1: 247-252.
Neoadjuvant chemoradiotherapy (CTRT) can effectively downstage esophageal squamous cell carcinoma (SCC) in patients with locally advanced disease and prolonged survival have been observed in patients with a pathological complete response (ypCR). This exploratory study aimed to identify immunological predictors of pCR after neoadjuvant CTRT within SCC microenvironment. The tumor regression after neoadjuvant therapy was measured according to the Mandard score system. Eighty-eight consecutive patients with SCC of the thoracic esophagus who received neoadjuvant CTRT were included in this retrospective study. Inclusion criteria were neoadjuvant CTRT and the availability of representative histological samples taken at diagnosis. We investigated immunohistochemical expression of CD4, Tbet, FoxP3, CD8, CD80, PD-L1, and PD-1, in the pretreatment biopsies and correlated the immunohistochemical profiles to patients' outcomes. After neoadjuvant CTRT, 23 patients had pCR, while 65 ones had partial response, stable disease or progression. PD-L1 expression and CD8+ and CD4+ lymphocyte rate were significantly higher in patients who had ypCR compared to those who had not (10 (0-55) vs 0 (0-0), P = 0.004, 73 (36-147) vs 21 (7-47), P = 0.0006 and 39 (23-74) vs 5 (0-13), P < 0.0001 respectively). The accuracy of expression of PD-L1+, CD8+, and CD4+ lymphocyte rate in identifying responders was AUC = 0.76 (P = 0.001), AUC = 0.81 (P = 0.0001) and AUC = 0.75 (P = 0.0001), respectively. Within the ypCR group, all patients with high infiltration of CD4+ T cell recurred/relapsed while only the 38.9% of those with low CD4+ T cell infiltration did the same (P = 0.058). PD-L1 expression and CD8+ and CD4+ lymphocyte rate were predictive of ypCR after neoadjuvant CTRT for SCC of the thoracic esophagus with adequate accuracy. Furthermore, recurrence/relapse was associated with high level of CD4+ T cell infiltration. However, the small sample size prevented to draw definitive conclusions; further studies are necessary to evaluate the prognostic role of these markers.
Matteo Fassan; Francesco Cavallin; Vincenza Guzzardo; Andromachi Kotsafti; Melania Scarpa; Matteo Cagol; Vanna Chiarion Sileni; Luca Maria Saadeh; Rita Alfieri; Ignazio Castagliuolo; Massimo Rugge; Carlo Castoro; Marco Scarpa. PD‐L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus. Cancer Medicine 2019, 8, 6036 -6048.
AMA StyleMatteo Fassan, Francesco Cavallin, Vincenza Guzzardo, Andromachi Kotsafti, Melania Scarpa, Matteo Cagol, Vanna Chiarion Sileni, Luca Maria Saadeh, Rita Alfieri, Ignazio Castagliuolo, Massimo Rugge, Carlo Castoro, Marco Scarpa. PD‐L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus. Cancer Medicine. 2019; 8 (13):6036-6048.
Chicago/Turabian StyleMatteo Fassan; Francesco Cavallin; Vincenza Guzzardo; Andromachi Kotsafti; Melania Scarpa; Matteo Cagol; Vanna Chiarion Sileni; Luca Maria Saadeh; Rita Alfieri; Ignazio Castagliuolo; Massimo Rugge; Carlo Castoro; Marco Scarpa. 2019. "PD‐L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus." Cancer Medicine 8, no. 13: 6036-6048.
Myoepithelioma of the soft tissue (MES) is a rare neoplasm, and available literature includes few studies with small sample sizes, thus limiting the comprehension of this disease. Hence, a systematic review was performed to summarize the available information on MES patients evaluated for surgical treatment. The MEDLINE/PubMed, EMBASE and SCOPUS databases were reviewed for eligible studies in January 2019. Inclusion criteria were: patients with MES; indication for wide resection or amputation; observational studies; articles published from 1997 to 2018; English language; reporting of outcome measures such as overall survival (OS), disease-free survival (DFS), recurrence, metastases. Studies not including humans were excluded. Quality appraisal was performed using the Methodological Index for Non-Randomized Studies (MINORS) tool. A narrative synthesis of included studies was conducted, a formal meta-analysis being unfeasible. Overall, 10 eligible studies including 233 MES patients were identified. The most frequent tumor sites were the limbs and trunk. Most patients underwent surgical treatment, with R0 resection margin rates ranging from 24% to 78%. During follow-up, local recurrence rates ranged from 17% to 50, and distant metastasis rates varied 8%–48%. At 5 years, OS rates ranged from 8% to 94% and DFS rates from 11% to 40%. The average MINORS score was 9.1 (range: 6–11). Surgical resection was often sub-optimal. The long-term prognosis was poor, with a non-negligible rate of disease recurrence and metastasis. On average, the quality of available information is moderate. The centralization of patient information in large international registries is warranted to provide a better understanding of MES biology and ultimately improve patient outcomes.
Marco Rastrelli; Paolo Del Fiore; Giovanni Battista Damiani; Simone Mocellin; Saveria Tropea; Romina Spina; Alessandra Costa; Francesco Cavallin; Carlo Riccardo Rossi. Myoepithelioma of the soft tissue: A systematic review of clinical reports. European Journal of Surgical Oncology 2019, 45, 1520 -1526.
AMA StyleMarco Rastrelli, Paolo Del Fiore, Giovanni Battista Damiani, Simone Mocellin, Saveria Tropea, Romina Spina, Alessandra Costa, Francesco Cavallin, Carlo Riccardo Rossi. Myoepithelioma of the soft tissue: A systematic review of clinical reports. European Journal of Surgical Oncology. 2019; 45 (9):1520-1526.
Chicago/Turabian StyleMarco Rastrelli; Paolo Del Fiore; Giovanni Battista Damiani; Simone Mocellin; Saveria Tropea; Romina Spina; Alessandra Costa; Francesco Cavallin; Carlo Riccardo Rossi. 2019. "Myoepithelioma of the soft tissue: A systematic review of clinical reports." European Journal of Surgical Oncology 45, no. 9: 1520-1526.
Merkel Cell Carcinoma (MCC) is a rare but highly aggressive neuroendocrine neoplasm of the skin. This study aimed at describing characteristics, treatment, and prognosis of a series of consecutive cases of MCC patients, in order to contribute to the investigation of this rare malignancy and provide better patient care. This is a retrospective cohort study including all 90 patients diagnosed and/or treated for MCC between 1991 and 2018 at the Veneto Institute of Oncology in Padua (Italy). Patient and tumor characteristics, treatment, and immunohistochemical data were extracted from a prospectively collected local database. There were 68 primary (76%) and 22 non-primary (15 occult primary, three metastatic, four recurrence) tumors (24%). CK20 expression was associated with reduced overall (HR 2.92, 95% CI 1.04–8.16) and disease-specific (HR 4.62, 95% CI 1.31–16.28) survival. Immunomodulatory regimens for treatment of other comorbidities were associated with reduced disease-specific ((HR 2.15, 95% CI 1.06–4.36) and recurrence-free (HR 3.08, 95% CI 1.44–6.57) survival. Iatrogenic immunomodulation resulted as the main factor associated with impaired prognosis. Lack of CK20 expression was associated with better survival.
Marco Rastrelli; Beatrice Ferrazzi; Francesco Cavallin; Vanna Chiarion Sileni; Jacopo Pigozzo; Alessio Fabozzi; Saveria Tropea; Antonella Vecchiato; Alessandra Costa; Alessandro Parisi; Carlo Riccardo Rossi; Paolo Del Fiore; Mauro Alaibac. Prognostic Factors in Merkel Cell Carcinoma: A Retrospective Single-Center Study in 90 Patients. Cancers 2018, 10, 350 .
AMA StyleMarco Rastrelli, Beatrice Ferrazzi, Francesco Cavallin, Vanna Chiarion Sileni, Jacopo Pigozzo, Alessio Fabozzi, Saveria Tropea, Antonella Vecchiato, Alessandra Costa, Alessandro Parisi, Carlo Riccardo Rossi, Paolo Del Fiore, Mauro Alaibac. Prognostic Factors in Merkel Cell Carcinoma: A Retrospective Single-Center Study in 90 Patients. Cancers. 2018; 10 (10):350.
Chicago/Turabian StyleMarco Rastrelli; Beatrice Ferrazzi; Francesco Cavallin; Vanna Chiarion Sileni; Jacopo Pigozzo; Alessio Fabozzi; Saveria Tropea; Antonella Vecchiato; Alessandra Costa; Alessandro Parisi; Carlo Riccardo Rossi; Paolo Del Fiore; Mauro Alaibac. 2018. "Prognostic Factors in Merkel Cell Carcinoma: A Retrospective Single-Center Study in 90 Patients." Cancers 10, no. 10: 350.
Stimulation is the most common intervention during neonatal resuscitation at birth, but scarce information is available on the actual methods, timing and efficacy of this basic step. To evaluate the occurrence, patterns and response to tactile stimulation at birth in a low-resource setting. We reviewed 150 video recordings of neonatal resuscitation at Beira Central Hospital (Beira, Mozambique). Timing, method, duration and response to tactile stimulation were evaluated. One hundred two out of 150 neonates (68.0%) received stimulation, while the remaining 48 (32.0%) received positive pressure ventilation and/or chest compressions directly. Overall, 546 stimulation episodes (median 4 episodes per subject, IQR 2–7) were performed. Median time to the first stimulation episode was 134 s (IQR 53–251); 29 neonates (28.4%) received stimulation within the first minute after birth. Multiple techniques of stimulation were administered in 66 neonates (64.7%), while recommended techniques (rubbing the back or flicking the soles of the feet) only in 9 (8.8%). Median duration of stimulation was 17 s (IQR 9–33). Only 9 neonates (8.8%) responded to stimulation. In a low-resource setting, stimulation of newly born infants at birth is underperformed. Adherence to international guidelines is low, resulting in delayed initiation, inadequate technique, prolonged duration and low response to stimulation. Back rubs may provide some benefits, but large prospective studies comparing different methods of stimulation are required.
Andrea Pietravalle; Francesco Cavallin; Anna Opocher; Stefania Madella; Maria Elena Cavicchiolo; Damiano Pizzol; Giovanni Putoto; Daniele Trevisanuto. Neonatal tactile stimulation at birth in a low-resource setting. BMC Pediatrics 2018, 18, 1 -7.
AMA StyleAndrea Pietravalle, Francesco Cavallin, Anna Opocher, Stefania Madella, Maria Elena Cavicchiolo, Damiano Pizzol, Giovanni Putoto, Daniele Trevisanuto. Neonatal tactile stimulation at birth in a low-resource setting. BMC Pediatrics. 2018; 18 (1):1-7.
Chicago/Turabian StyleAndrea Pietravalle; Francesco Cavallin; Anna Opocher; Stefania Madella; Maria Elena Cavicchiolo; Damiano Pizzol; Giovanni Putoto; Daniele Trevisanuto. 2018. "Neonatal tactile stimulation at birth in a low-resource setting." BMC Pediatrics 18, no. 1: 1-7.
Background: The association between shorter time to diagnosis and favorable outcome is still unproven in esophageal cancer. This study aims to evaluate the effect of time to diagnosis on patient prognosis. Material and methods: Retrospective cohort study of all 3613 symptomatic patients referred for esophageal cancer to our center from 1980 to 2011. Time to diagnosis was calculated as the number of days from first symptom onset to the diagnosis of esophageal cancer. The main outcome measures were: resectability and severe malnutrition at diagnosis; postoperative morbidity, mortality and survival. Results: Longer time to diagnosis was significantly associated with severe malnutrition at diagnosis (odds ratio (OR): 1.003, 95% confidence interval (C.I.).: 1.001–1.006) but not with resectability (OR: 0.997, 95% C.I.: 0.994–1.001). Longer time to diagnosis was not associated with postoperative morbidity (OR: 1.000, 95% C.I.: 0.998–1.003), postoperative mortality (OR: 1.002, 95% C.I.: 0.998–1.006), five-year overall survival (hazard ratio (HR): 0.999, 95% C.I.: 0.997–1.001) or five-year disease free survival (HR: 0.999, 95% C.I.: 0.998–1.001). Conclusion: Longer time to diagnosis did not affect resectability, postoperative morbidity or survival. Further campaigns to raise awareness of cancer among population and primary health care providers may have limited effect on clinical outcome.
Francesco Cavallin; Marco Scarpa; Matteo Cagol; Rita Alfieri; Alberto Ruol; Vanna Chiarion Sileni; Massimo Rugge; Ermanno Ancona; Carlo Castoro. Time to diagnosis in esophageal cancer: a cohort study. Acta Oncologica 2018, 57, 1179 -1184.
AMA StyleFrancesco Cavallin, Marco Scarpa, Matteo Cagol, Rita Alfieri, Alberto Ruol, Vanna Chiarion Sileni, Massimo Rugge, Ermanno Ancona, Carlo Castoro. Time to diagnosis in esophageal cancer: a cohort study. Acta Oncologica. 2018; 57 (9):1179-1184.
Chicago/Turabian StyleFrancesco Cavallin; Marco Scarpa; Matteo Cagol; Rita Alfieri; Alberto Ruol; Vanna Chiarion Sileni; Massimo Rugge; Ermanno Ancona; Carlo Castoro. 2018. "Time to diagnosis in esophageal cancer: a cohort study." Acta Oncologica 57, no. 9: 1179-1184.
Data on long-term health-related quality of life (HRQL) after esophagectomy for cancer show contradictory results. The aim was to analyze long-term HRQL at 3 or more years after esophagectomy. Survivors were identified among patients who had undergone esophagectomy during 2007-2013 using the local clinic database. Quality of life was assessed using the European Organization for Research and Treatment of Cancer QLQ-C30 and OG25 questionnaires. Specific aspects were selected a priori and compared with published scores from European healthy subjects (mean difference, MD). Sixty-five long-term survivors (median follow-up 4 years) were identified. All functional scales and most symptom scales were clinically similar between EC long-term survivors and European healthy subjects. Survivors reported more problems concerning eating (MD 13.1, 95% C.I. 10.6-15.6) and reflux (MD 19.7, 95% C.I. 15.9-23.5). HQRL variation from discharge to long term was available in 27 participants who reported improvements in role functioning (MD 40.1, 95%C.I. 24.3-56.0) and dysphagia (MD −41.9, 95% C.I. −51.7 to 32.0). Long-term HRQL after esophagectomy is similar between EC survivors and European healthy subjects, despite persisting reflux and eating problems. Further research may focus on improvements of postoperative alimentary habits.
Silvia Mantoan; Francesco Cavallin; Eleonora Pinto; Luca M. Saadeh; Rita Alfieri; Matteo Cagol; Maria C. Bellissimo; Carlo Castoro; Marco Scarpa. Long-term quality of life after esophagectomy with gastric pull-up. Journal of Surgical Oncology 2018, 117, 970 -976.
AMA StyleSilvia Mantoan, Francesco Cavallin, Eleonora Pinto, Luca M. Saadeh, Rita Alfieri, Matteo Cagol, Maria C. Bellissimo, Carlo Castoro, Marco Scarpa. Long-term quality of life after esophagectomy with gastric pull-up. Journal of Surgical Oncology. 2018; 117 (5):970-976.
Chicago/Turabian StyleSilvia Mantoan; Francesco Cavallin; Eleonora Pinto; Luca M. Saadeh; Rita Alfieri; Matteo Cagol; Maria C. Bellissimo; Carlo Castoro; Marco Scarpa. 2018. "Long-term quality of life after esophagectomy with gastric pull-up." Journal of Surgical Oncology 117, no. 5: 970-976.
Nodal skip metastasis is a prognostic factor in some sites of malignancies, but its role in esophageal cancer is still unclear. The present study aimed to investigate occurrence and effect of nodal skip metastases in thoracic esophageal squamous cell carcinoma. All 578 patients undergoing esophagectomy for thoracic esophageal squamous cell carcinoma at the Center for Esophageal Diseases located in Padova between January 1992 and December 2010 were retrospectively evaluated. Selection criteria were R0 resection, pathological M0 stage and pathological lymph node involvement. Patients receiving neoadjuvant therapy were excluded. The selection identified 88 patients with lymph node involvement confirmed by pathological evaluation. Sixteen patients (18.2%) had nodal skip metastasis. Adjusting for the number of lymph node metastases, patient with nodal skip metastasis had similar 5-year overall survival (14% vs. 13%, p = 0.93) and 5-year disease free survival (14% vs. 9%, p = 0.48) compared to patients with both peritumoral and distant lymph node metastases. The risk difference of nodal skip metastasis was: -24.1% (95% C.I. -43.1% to -5.2%) in patients with more than one lymph node metastasis compared to those with one lymph node metastasis; -2.3% (95% C.I. -29.8% to 25.2%) in middle thoracic esophagus and -23.0% (95% C.I. -47.8% to 1.8%) in lower thoracic esophagus compared to upper thoracic esophagus; 18.1% (95% C.I. 3.2% to 33.0%) in clinical N0 stage vs. clinical N+ stage. Nodal skip metastasis is a common pattern of metastatic lymph involvement in thoracic esophageal squamous cell carcinoma. However, neither overall survival nor disease free survival are associated with nodal skip metastasis occurrence.
Francesco Cavallin; Rita Alfieri; Marco Scarpa; Matteo Cagol; Alberto Ruol; Matteo Fassan; Massimo Rugge; Ermanno Ancona; Carlo Castoro. Nodal skip metastasis in thoracic esophageal squamous cell carcinoma: a cohort study. BMC Surgery 2017, 17, 49 .
AMA StyleFrancesco Cavallin, Rita Alfieri, Marco Scarpa, Matteo Cagol, Alberto Ruol, Matteo Fassan, Massimo Rugge, Ermanno Ancona, Carlo Castoro. Nodal skip metastasis in thoracic esophageal squamous cell carcinoma: a cohort study. BMC Surgery. 2017; 17 (1):49.
Chicago/Turabian StyleFrancesco Cavallin; Rita Alfieri; Marco Scarpa; Matteo Cagol; Alberto Ruol; Matteo Fassan; Massimo Rugge; Ermanno Ancona; Carlo Castoro. 2017. "Nodal skip metastasis in thoracic esophageal squamous cell carcinoma: a cohort study." BMC Surgery 17, no. 1: 49.
High fidelity simulation has been executed to allow the evaluation of technical and non-technical skills of health caregivers. Our objective was to assess technical and non-technical performances of low level hospitals health caregivers who attended a Neonatal Resuscitation course using high fidelity simulation in a standard-setting scenario. Twenty-three volunteers were asked to manage a simple scenario (infant with secondary apnea) after the course. Technical and non-technical skills were assessed by using previously published scores. Performances were assessed during the scenario and after 2 months by filmed video recordings. Sixteen (69.5%) participants failed to pass the minimum required technical score. Staff experience and participation in previous courses were associated to higher score in technical and non-technical skills, while working in level I or II hospitals did not affect the scores. Previous experience in neonatal resuscitation requiring positive pressure ventilation was associated to better non-technical performance. Technical and non-technical scores were significantly correlated (r = 0.67, p = 0.0005). Delayed and direct evaluation of technical skills provided the same scores. A neonatal resuscitation course, performed by using a high fidelity simulation manikin, had a limited impact on technical and non-technical skills of participants working in low level hospitals. Training programs should be tailored to the participants’ professional background and to the more relevant sessions.
Giuseppe De Bernardo; Desirée Sordino; Francesco Cavallin; Veronica Mardegan; Nicoletta Doglioni; Maria Luisa Tataranno; Daniele Trevisanuto. Performances of low level hospital health caregivers after a neonatal resuscitation course. Italian Journal of Pediatrics 2016, 42, 1 -7.
AMA StyleGiuseppe De Bernardo, Desirée Sordino, Francesco Cavallin, Veronica Mardegan, Nicoletta Doglioni, Maria Luisa Tataranno, Daniele Trevisanuto. Performances of low level hospital health caregivers after a neonatal resuscitation course. Italian Journal of Pediatrics. 2016; 42 (1):1-7.
Chicago/Turabian StyleGiuseppe De Bernardo; Desirée Sordino; Francesco Cavallin; Veronica Mardegan; Nicoletta Doglioni; Maria Luisa Tataranno; Daniele Trevisanuto. 2016. "Performances of low level hospital health caregivers after a neonatal resuscitation course." Italian Journal of Pediatrics 42, no. 1: 1-7.
This study demonstrated that, after LHD was performed by experienced surgeons, the true incidence of postoperative GERD is very low. The incidence of this possible complication should be assessed by pH monitoring because endoscopic findings and symptoms may be misleading.
Renato Salvador; Elisa Pesenti; Laura Gobbi; Giovanni Capovilla; Lorenzo Spadotto; Guerrino Voltarel; Francesco Cavallin; Loredana Nicoletti; Michele Valmasoni; Alberto Ruol; Stefano Merigliano; Mario Costantini. Postoperative Gastroesophageal Reflux After Laparoscopic Heller-Dor for Achalasia: True Incidence with an Objective Evaluation. Journal of Gastrointestinal Surgery 2016, 21, 17 -22.
AMA StyleRenato Salvador, Elisa Pesenti, Laura Gobbi, Giovanni Capovilla, Lorenzo Spadotto, Guerrino Voltarel, Francesco Cavallin, Loredana Nicoletti, Michele Valmasoni, Alberto Ruol, Stefano Merigliano, Mario Costantini. Postoperative Gastroesophageal Reflux After Laparoscopic Heller-Dor for Achalasia: True Incidence with an Objective Evaluation. Journal of Gastrointestinal Surgery. 2016; 21 (1):17-22.
Chicago/Turabian StyleRenato Salvador; Elisa Pesenti; Laura Gobbi; Giovanni Capovilla; Lorenzo Spadotto; Guerrino Voltarel; Francesco Cavallin; Loredana Nicoletti; Michele Valmasoni; Alberto Ruol; Stefano Merigliano; Mario Costantini. 2016. "Postoperative Gastroesophageal Reflux After Laparoscopic Heller-Dor for Achalasia: True Incidence with an Objective Evaluation." Journal of Gastrointestinal Surgery 21, no. 1: 17-22.
Neonatal hypothermia is an important challenge associated with morbidity and mortality. Preventing neonatal hypothermia is important in high-resource countries, but is of fundamental importance in low-resource settings where supportive care is limited. Kangaroo mother care (KMC) is a low-cost intervention that, whenever possible, is strongly recommended for temperature maintenance. During KMC, the World Health Organization (WHO) guidelines recommend the use of a cap/hat, but its effect on temperature control during KMC remains to be established. In the hospitals participating in the projects of the non-governmental organization CUAMM, KMC represents a standard of care, but the heads of the babies often remain uncovered due to local habits or to the unavailability of a cap. The aim of the present study will be to assess the effectiveness and safety of using a woolen cap in maintaining normothermia in low-birth-weight infants (LBWI) during KMC. This is a multicenter (three hospitals), multicountry (three countries), prospective, unblinded, randomized controlled trial of KMC treatment with and without a woolen cap in LBWI. After obtaining parental consent, all infants with a birth weight below 2500 g and who are candidates for KMC, based on the clinical decision of the attending physician, will be assigned to the KMC with a woolen cap group or to the KMC without a woolen cap group in a 1:1 ratio according to a computer-generated, randomized sequence. The duration of the study will be until the patient's discharge, with a maximum treatment duration of 7 days. The primary outcome measure will be whether the infants' temperatures remain within the normal range (36.5-37.5 °C) in the course of KMC during the intervention. In all participants, axillary temperature will be measured with a digital thermometer four times per day. In addition, maternal and room temperature will be recorded. Secondary outcome measures will be: episodes of apnea; sepsis; mortality before hospital discharge; in-hospital growth; and age at discharge. The findings of this study will be important for other units/settings in high- as well low-resource countries where KMC is routinely performed. Based on the results of the present study, we could speculate whether the use of a woolen cap may help to maintain the neonate within the normal thermal range. Furthermore, potential complications such as hyperthermia will be strictly monitored and collected. ClinicalTrials.gov Identifier: NCT02645526 (registered on 31 December 2015).
Daniele Trevisanuto; Giovanni Putoto; Damiano Pizzol; Tiziana Serena; Fabio Manenti; Silvia Varano; Eleonora Urso; William Massavon; Ademe Tsegaye; Oliver Wingi; Emanuel Onapa; Giulia Segafredo; Francesco Cavallin. Is a woolen cap effective in maintaining normothermia in low-birth-weight infants during kangaroo mother care? Study protocol for a randomized controlled trial. Trials 2016, 17, 265 .
AMA StyleDaniele Trevisanuto, Giovanni Putoto, Damiano Pizzol, Tiziana Serena, Fabio Manenti, Silvia Varano, Eleonora Urso, William Massavon, Ademe Tsegaye, Oliver Wingi, Emanuel Onapa, Giulia Segafredo, Francesco Cavallin. Is a woolen cap effective in maintaining normothermia in low-birth-weight infants during kangaroo mother care? Study protocol for a randomized controlled trial. Trials. 2016; 17 (1):265.
Chicago/Turabian StyleDaniele Trevisanuto; Giovanni Putoto; Damiano Pizzol; Tiziana Serena; Fabio Manenti; Silvia Varano; Eleonora Urso; William Massavon; Ademe Tsegaye; Oliver Wingi; Emanuel Onapa; Giulia Segafredo; Francesco Cavallin. 2016. "Is a woolen cap effective in maintaining normothermia in low-birth-weight infants during kangaroo mother care? Study protocol for a randomized controlled trial." Trials 17, no. 1: 265.
We assessed the effect of an adapted neonatal resuscitation program (NRP) course on healthcare providers’ performances in a low-resource setting through the use of video recording. A video recorder, mounted to the radiant warmers in the delivery rooms at Beira Central Hospital, Mozambique, was used to record all resuscitations. One-hundred resuscitations (50 before and 50 after participation in an adapted NRP course) were collected and assessed based on a previously published score. All 100 neonates received initial steps; from these, 77 and 32 needed bag-mask ventilation (BMV) and chest compressions (CC), respectively. There was a significant improvement in resuscitation scores in all levels of resuscitation from before to after the course: for “initial steps”, the score increased from 33% (IQR 28–39) to 44% (IQR 39–56), p<0.0001; for BMV, from 20% (20–40) to 40% (40–60), p = 0.001; and for CC, from 0% (0–10) to 20% (0–50), p = 0.01. Times of resuscitative interventions after the course were improved in comparison to those obtained before the course, but remained non-compliant with the recommended algorithm. Although resuscitations remained below the recommended standards in terms of quality and time of execution, clinical practice of healthcare providers improved after participation in an adapted NRP course. Video recording was well-accepted by the staff, useful for objective assessment of performance during resuscitation, and can be used as an educational tool in a low-resource setting.
Daniele Trevisanuto; Federica Bertuola; Paolo Lanzoni; Francesco Cavallin; Eduardo Matediana; Olivier Wingi Manzungu; Ermelinda Gomez; Liviana Da Dalt; Giovanni Putoto. Effect of a Neonatal Resuscitation Course on Healthcare Providers’ Performances Assessed by Video Recording in a Low-Resource Setting. PLOS ONE 2015, 10, e0144443 .
AMA StyleDaniele Trevisanuto, Federica Bertuola, Paolo Lanzoni, Francesco Cavallin, Eduardo Matediana, Olivier Wingi Manzungu, Ermelinda Gomez, Liviana Da Dalt, Giovanni Putoto. Effect of a Neonatal Resuscitation Course on Healthcare Providers’ Performances Assessed by Video Recording in a Low-Resource Setting. PLOS ONE. 2015; 10 (12):e0144443.
Chicago/Turabian StyleDaniele Trevisanuto; Federica Bertuola; Paolo Lanzoni; Francesco Cavallin; Eduardo Matediana; Olivier Wingi Manzungu; Ermelinda Gomez; Liviana Da Dalt; Giovanni Putoto. 2015. "Effect of a Neonatal Resuscitation Course on Healthcare Providers’ Performances Assessed by Video Recording in a Low-Resource Setting." PLOS ONE 10, no. 12: e0144443.
Objective To compare preductal oxygen saturation (SpO2), heart rate (HR) and cord blood pH after birth in healthy term neonates delivered by elective caesarean delivery (CD) and vaginal delivery (VD), managed according to 2010 Neonatal Resuscitation Guidelines. Design In a prospective cohort study, sensors were placed on the right hand of the neonate. Setting III level Maternity ward of the Department of Obstetrics and Gynaecology of Padua University, Padua, Italy. Main outcome measures SpO2 and HR were recorded during the first 10 min after birth. Umbilical artery blood gas analysis was obtained immediately after delivery. Patients We studied 60 newborn infants by elective CD and 60 by VD. Results The SpO2 gradually significantly improved during the first 10 min of life (p<0.0001), with a trend towards a slower increase in caesarean-delivered neonates (p=0.09) (Friedman's two-way non-parametric analysis of variance (ANOVA)). Instead, HR varied during the first 10 min of life (p=0.001) without significant difference between the two delivery groups (p=0.41). Umbilical artery pH values were lower in VD (p=0.005). At 10th minute, elective CD had a significantly negative effect on SpO2 (ß=−2.44; 95% CI −4.52 to −0.36; p=0.02) with respect to VD. Conversely, at 10th minute, delivery mode had no statistically significant effect on HR (ß=0.33; 95% CI −9.39 to 10.01; p=0.95). Conclusions In healthy term neonates, the SpO2 gradually improved during the first 10 min of life. At 10th minute, elective CD had a significantly negative effect on SpO2, but these changes did not result in an impaired HR pattern.
Vincenzo Zanardo; Valentina Dal Cengio; Matteo Parotto; Francesco Cavallin; Daniele Trevisanuto. Elective caesarean delivery adversely affects preductal oxygen saturation during birth transition. Archives of Disease in Childhood - Fetal and Neonatal Edition 2015, 101, F339 -F343.
AMA StyleVincenzo Zanardo, Valentina Dal Cengio, Matteo Parotto, Francesco Cavallin, Daniele Trevisanuto. Elective caesarean delivery adversely affects preductal oxygen saturation during birth transition. Archives of Disease in Childhood - Fetal and Neonatal Edition. 2015; 101 (4):F339-F343.
Chicago/Turabian StyleVincenzo Zanardo; Valentina Dal Cengio; Matteo Parotto; Francesco Cavallin; Daniele Trevisanuto. 2015. "Elective caesarean delivery adversely affects preductal oxygen saturation during birth transition." Archives of Disease in Childhood - Fetal and Neonatal Edition 101, no. 4: F339-F343.