Nafiseh Khosravi Dehaghi

Dr. Nafiseh Khosravi Dehaghi

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Research Focus & Metrics

Academic Career Length

17Years (2010-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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25 November 2019 in Biomolecules
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Journal Article
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Javad Sharifi-RadJavad Sharifi-Rad
Javad Sharifi-Rad
FKFarzad Kobarfard
Farzad Kobarfard
AAAthar Ata
Athar Ata
SASeyed Abdulmajid Ayatollahi
Seyed Abdulmajid Ayatollahi
NDNafiseh Khosravi Dehaghi
Nafiseh Khosravi Dehaghi
Natália Cruz-MartinsNatália Cruz-Martins
Natália Cruz-Martins
Members of the Prosopis genus are native to America, Africa and Asia, and have long been used in traditional medicine. The Prosopis species most commonly used for medicinal purposes are P. africana, P. alba, P. cineraria, P. farcta, P. glandulosa, P. juliflora, P. nigra, P. ruscifolia and P. spicigera, which are highly effective in asthma, birth/postpartum pains, callouses, conjunctivitis, diabetes, diarrhea, expectorant, fever, flu, lactation, liver infection, malaria, otitis, pains, pediculosis, rheumatism, scabies, skin inflammations, spasm, stomach ache, bladder and pancreas stone removal. Flour, syrup, and beverages from Prosopis pods have also been potentially used for foods and food supplement formulation in many regions of the world. In addition, various in vitro and in vivo studies have revealed interesting antiplasmodial, antipyretic, anti-inflammatory, antimicrobial, anticancer, antidiabetic and wound healing effects. The phytochemical composition of Prosopis plants, namely their content of C-glycosyl flavones (such as schaftoside, isoschaftoside, vicenin II, vitexin and isovitexin) has been increasingly correlated with the observed biological effects. Thus, given the literature reports, Prosopis plants have positive impact on the human diet and general health. In this sense, the present review provides an in-depth overview of the literature data regarding Prosopis plants’ chemical composition, pharmacological and food applications, covering from pre-clinical data to upcoming clinical studies.

15 April 2019 in PLOS ONE
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HPHelen Pourmazaheri
Helen Pourmazaheri
ASAboozar Soorni
Aboozar Soorni
BKBahram Baghban Kohnehrouz
Bahram Baghban Kohnehrouz
NDNafiseh Khosravi Dehaghi
Nafiseh Khosravi Dehaghi
EKEnayatollah Kalantar
Enayatollah Kalantar
MNMohammad Reza Naghavi
Mohammad Reza Naghavi
Chelidonium majus is a traditional medicinal plant, which commonly known as a rich resource for the major benzylisoquinoline alkaloids (BIAs), including morphine, sanguinarine, and berberine. To understand the biosynthesis of C. majus BIAs, we performed de novo transcriptome sequencing of its leaf and root tissues using Illumina technology. Following comprehensive evaluation of de novo transcriptome assemblies produced with five programs including Trinity, Bridger, BinPacker, IDBA-tran, and Velvet/Oases using a series of k-mer sizes (from 25 to 91), BinPacker was found to produce the best assembly using a k-mer of 25. This study reports the results of differential gene expression (DGE), functional annotation, gene ontology (GO) analysis, classification of transcription factor (TF)s, and SSR and miRNA discovery. Our DGE analysis identified 6,028 transcripts that were up-regulated in the leaf, and 4,722 transcripts that were up-regulated in the root. Further investigations showed that most of the genes involved in the BIA biosynthetic pathway are significantly expressed in the root compared to the leaf. GO analysis showed that the predominant GO domain is “cellular component”, while TF analysis found bHLH to be the most highly represented TF family. Our study further identified 10 SSRs, out of a total of 39,841, that showed linkage to five unigenes encoding enzymes in the BIA pathway, and 10 conserved miRNAs that were previously not detected in this plant. The comprehensive transcriptome information presented herein provides a foundation for further explorations on study of the molecular mechanisms of BIA synthesis in C. majus.

6 April 2013
Verified
Journal Article
Closed access
MKMahnaz Khanavi
Mahnaz Khanavi
HVHassan Vatandoost
Hassan Vatandoost
NDNafiseh Khosravi Dehaghi
Nafiseh Khosravi Dehaghi
ASAlireza Sanei-Dehkordi
Alireza Sanei-Dehkordi
MSMohammad Mehdi Sedaghat
Mohammad Mehdi Sedaghat
FHFarzaneh Hadjiakhoondi
Farzaneh Hadjiakhoondi

16 November 2011 in Journal of Natural Medicines
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Journal Article
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HEH. Monsef Esfahani
H. Monsef Esfahani
ZEZ. Navvab Esfahani
Z. Navvab Esfahani
NDNafiseh Khosravi Dehaghi
Nafiseh Khosravi Dehaghi
AHA. Hosseini-Sharifabad
A. Hosseini-Sharifabad
KTK. Tabrizian
K. Tabrizian
SOSeyed Nasser Ostad
Seyed Nasser Ostad

1 January 2019 in Journal of Reports in Pharmaceutical Sciences
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Journal Article
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NDNafiseh Khosravi Dehaghi
Nafiseh Khosravi Dehaghi
ZEZeinab Etratkhah
Zeinab Etratkhah
SESeyed Esmaeil Sadat Ebrahimi
Seyed Esmaeil Sadat Ebrahimi
YSYousef Seifalizadeh
Yousef Seifalizadeh
Context: Ficus benghalensis (Moraceae) is an evergreen tree found in south and southeast of Iran as wild and cultivated plants. Different parts of this plant have different effects such as antitumor, antipyretic, analgesic and anti-inflammatory. Aims: The aim of this study was investigated the phytochemical screening and antioxidant activities of different fractions of plant roots. Materials and Methods: Phytochemical investigation was done by different methods in references. Antioxidant activity was evaluated by DPPH and FRAP assay. All chemical materials and solvents were prepared from Sigma-Aldrich, Scharlau and Merk. Statistical Analysis: All measurements were carried out in triplicate and the data were expressed as mean ± SD. Statistical analysis was performed using one-way analysis of variance (ANOVA) and tukey test. Results: Phytochemical screening showed steroids, flavonoids, tannins, phenolic compounds, and anthraquinone glycoside are F. benghalensis constituents. This plant had antioxidant activity, but it was lower than the Indian kinds. Conclusion: This study elucidated Ficus benghalensis could be useful plant with antioxidant activity. Further investigation needs for details.

1 September 2012 in Phytochemistry Letters
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Journal Article
Closed access
NDNafiseh Khosravi Dehaghi
Nafiseh Khosravi Dehaghi
Daowan LaiDaowan Lai
Daowan Lai
YAYaghoub Amanzadeh
Yaghoub Amanzadeh
SSSeyed Smail Sadat-Ebrahimi
Seyed Smail Sadat-Ebrahimi
Peter ProkschPeter Proksch
Peter Proksch