Prof. Wei Xiong

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Academic Career Length

19Years (2008-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 July 2025 in Scientific Reports

Journal Article

Quality and content evaluation of thyroid eye disease treatment information on TikTok and Bilibili

Haisheng Wang

Huahong Zhang

Jiamin Cao

Feng Zhang

Wei Xiong

Thyroid eye disease (TED) is an autoimmune condition that commonly impacts patients’ visual function, appearance, and psychological well-being. Challenges in TED management include low early detection rates and large variation in treatment response. Video platforms like TikTok and Bilibili are increasingly utilized for health information dissemination, yet the quality of TED treatment content on these platforms varies significantly. This cross-sectional study collected videos on “甲亢突眼的治疗” from TikTok and Bilibili in March 2025. After applying exclusion criteria, 152 videos (89 from TikTok, 63 from Bilibili) were analyzed. Quality, reliability, and educational value were assessed using the Global Quality Score (GQS), modified DISCERN (mDISCERN), Patient Education Materials Assessment Tool (PEMAT), and Journal of the American Medical Association (JAMA) benchmark criteria. Additionally, the study analyzed video content integrity, uploader identity, and the correlation with user interaction data. TikTok videos scored higher in quality (GQS: 3.00 ± 0.58; mDISCERN: 3.17 ± 0.73) compared to Bilibili (GQS: 2.65 ± 0.65; mDISCERN: 2.21 ± 0.88; p < 0.001). On Bilibili, 62% of videos were uploaded by Traditional Chinese Medicine (TCM) physicians, yet these scored lower in quality. Professionally uploaded content, particularly by ophthalmologists, outperformed non-professional videos (e.g., patient). However, the video interaction metrics uploaded by patients showed better performance. In terms of content, only 27% addressed staged treatment, and 11.8% mentioned risk factor control. Correlation analysis revealed strong correlations between interaction data, but interaction data have no correlation with GQS, mDISCERN, and PEMAT scores. Short video platforms exhibit a dual role in the dissemination of TED treatment information: enhancing public awareness of diseases through professional content while risking misinformation due to inadequate auditing. Recommended interventions include robust platform certification, active involvement of medical organizations in content creation, and public education on prioritizing verified sources.

14 February 2023 in Frontiers in Immunology

Journal Article

A cause–effect relationship between Graves’ disease and the gut microbiome contributes to the thyroid–gut axis: A bidirectional two-sample Mendelian randomization study

Jiamin Cao

Nuo Wang

Yong Luo

Chen Ma

Zhuokun Chen

Wei Xiong

Background: An association between Graves’ disease (GD) and the gut microbiome has been identified, but the causal effect between them remains unclear.Methods: Bidirectional two-sample Mendelian randomization (MR) analysis was used to detect the causal effect between GD and the gut microbiome. Gut microbiome data were derived from samples from a range of different ethnicities (18,340 samples) and data on GD were obtained from samples of Asian ethnicity (212,453 samples). Single nucleotide polymorphisms (SNPs) were selected as instrumental variables according to different criteria. They were used to evaluate the causal effect between exposures and outcomes through inverse-variance weighting (IVW), weighted median, weighted mode, MR-Egger, and simple mode methods. F-statistics and sensitivity analyses were performed to evaluate bias and reliability.Results: In total, 1,560 instrumental variables were extracted from the gut microbiome data (p< 1 × 10⁵). The classes Deltaproteobacteria [odds ratio (OR) = 3.603] and Mollicutes, as well as the genera Ruminococcus torques group, Oxalobacter, and Ruminococcaceae UCG 011 were identified as risk factors for GD. The family Peptococcaceae and the genus Anaerostipes (OR = 0.489) were protective factors for GD. In addition, 13 instrumental variables were extracted from GD (p< 1 × 10^–8), causing one family and eight genera to be regulated. The genus Clostridium innocuum group (p = 0.024, OR = 0.918) and Anaerofilum (p = 0.049, OR = 1.584) had the greatest probability of being regulated. Significant bias, heterogeneity, and horizontal pleiotropy were not detected.Conclusion: A causal effect relationship exists between GD and the gut microbiome, demonstrating regulatory activity and interactions, and thus providing evidence supporting the involvement of a thyroid–gut axis.

1 May 2025 in Digital Health

Journal Article

Quality of cataract-related videos on TikTok and its influencing factors: A cross-sectional study

Jiamin Cao

Feng Zhang

Ziyi Zhu

Wei Xiong

Objective: Short videos are increasingly being used to disseminate health information. However, the quality of videos on common ophthalmic conditions such as cataract has not been systematically evaluated. Methods: This study employed a cross-sectional design. The TikTok platform was searched using the term “cataract” from 20:00 to 24:00 on 8 November 2024, without any restrictions. The top 100 retrieved videos were included in the study. They were rated using The Journal of American Medical Association ( JAMA ) benchmark criteria, Global Quality Score (GQS) scale, modified Decision-making Information Support Criteria for Evaluating the Reliability of Non-randomised Studies score, and Patient Education Materials Assessment Tool for Audio Visual Content. Videos by different groups were compared for quality and their underlying factors. Results: The top 100 videos had an average of 2009.1 likes, 795.65 comments, 2628.91 shares, and 554.08 saves. Their JAMA benchmark criteria, GQS, the modified Decision-making Information Support Criteria for Evaluating the Reliability of Non-randomised Studies score, and the Patient Education Materials Assessment Tool for Audio Visual Content score ratings differed ( p < .05) with account ownership, doctor rank, and video content. More videos were uploaded by institutions and physicians than by nonphysicians ( p < .05). The number of likes, comments, favorites, and shares of videos was not correlated with quality (Spearman correlation; p > .05). Further regression analysis confirmed that video quality can be predicted using account ownership. Conclusion: The quality of cataract-related short videos on platforms has room for improvement. Users may estimate video quality based on the identity of the content creator.

17 November 2021 in Graefe's Archive for Clinical and Experimental Ophthalmology

Journal Article

The risk factors for Graves’ ophthalmopathy

Jiamin Cao

Yuhe Su

Zhuokun Chen

Chen Ma

Wei Xiong

5 May 2024 in Advanced Science

Journal Article

Mitochondria‐Targeted Nanoadjuvants Induced Multi‐Functional Immune‐Microenvironment Remodeling to Sensitize Tumor Radio‐Immunotherapy

Zaigang Zhou

Cheng Li

Chao Li

Lei Zhou

Shuo Tan

Wei Xiong

It is newly revealed that collagen works as a physical barrier to tumor immune infiltration, oxygen perfusion, and immune depressor in solid tumors. Meanwhile, after radiotherapy (RT), the programmed death ligand‐1 (PD‐L1) overexpression and transforming growth factor‐β (TGF‐β) excessive secretion would accelerate DNA damage repair and trigger T cell exclusion to limit RT efficacy. However, existing drugs or nanoparticles can hardly address these obstacles of highly effective RT simultaneously, effectively, and easily. In this study, it is revealed that inducing mitochondria dysfunction by using oxidative phosphorylation inhibitors like Lonidamine (LND) can serve as a highly effective multi‐immune pathway regulation strategy through PD‐L1, collagen, and TGF‐β co‐depression. Then, IR‐LND is prepared by combining the mitochondria‐targeted molecule IR‐68 with LND, which then is loaded with liposomes (Lip) to create IR‐LND@Lip nanoadjuvants. By doing this, IR‐LND@Lip more effectively sensitizes RT by generating more DNA damage and transforming cold tumors into hot ones through immune activation by PD‐L1, collagen, and TGF‐β co‐inhibition. In conclusion, the combined treatment of RT and IR‐LND@Lip ultimately almost completely suppressed the growth of bladder tumors and breast tumors.