The objective of present study was to evaluate the effect of Ca salts of palm fatty acids on milk production, milk fat, plasma metabolites, and reproductive parameters in early-lactating Nili Ravi buffaloes. Sixteen early-lactating Nili Ravi buffaloes received 2 treatments in a completely randomized design with a period length of 120-d. The treatments were 1) Ctrl = basal diet without supplementation of fat, 2) Ca-FA = basal diet with calcium salts of palm fatty acids supplementation. The Ca-FA treatment increased the 3.5% fat-corrected milk yield by 11.0% compared with the Ctrl, whereas, the actual milk yield remained unaffected. The Ca-FA treatment increased the concentration of milk fat and milk fat yield by 3.5 and 11.2%, respectively, compared with the Ctrl. However, the Ca-FA treatment did not change the plasma urea nitrogen, glucose, and triglyceride, compared with the Ctrl. Similarly, the reproductive indices were not different between Ca-FA treatment versus Ctrl. In conclusion, the Ca-FA are useful to increase milk production and milk fat yield without effecting the plasma metabolites and reproductive responses in early-lactating buffalo.