The article aims to explore some new classes of differential equations and associated integral equations for some hybrid families of Laguerre polynomials. The recurrence relations and differential, integro-differential and partial differential equations for the hybrid Laguerre–Appell polynomials are derived via the factorization method. An analogous study of these results for the hybrid Laguerre–Bernoulli, Euler and Genocchi polynomials is presented. Further, the Volterra integral equations for the hybrid Laguerre–Appell polynomials and for their corresponding members are also explored.